4FYS.A | ANPEP

General Structure Information

PDB ID	4fys
HGNC Gene Label(s)	ANPEP
Structure Name	human aminopeptidase n (cd13) in complex with angiotensin iv
Resolution	2.01Å
Reference	AUTH A.H.WONG,D.ZHOU,J.M.RINITITL THE X-RAY CRYSTAL STRUCTURE OF HUMAN AMINOPEPTIDASE NTITL 2 REVEALS A NOVEL DIMER AND THE BASIS FOR PEPTIDE PROCESSING.REF J.BIOL.CHEM. V. 287 36804 2012REFN ISSN 0021-9258PMID 22932899DOI 10.1074/JBC.M112.398842

Variant Set Distributions

ExAC Variants

Number Of Residues	902
Number Of SNVs	244
Number Of Permutations	81961
Optimal Distance Threshold	14.0
K Statistic	0.051
p-value	0.969

COSMIC

Number Of Residues	902
Number Of SNVs	24
Number Of Permutations	30883
Optimal Distance Threshold	19.0
K Statistic	0.069
p-value	0.216

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	244
Number Of COSMIC SNVs	22
Optimal Distance Threshold	19.0
K Statistic	-0.046
p-value	0.386

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:90349591		R>H	A:75	(110.80, 20.92, 42.01)
15:90349592		R>C	A:75	(110.80, 20.92, 42.01)
15:90349579	rs144915494	T>M	A:79	(120.91, 22.53, 48.46)
15:90349567	COSM3988209	D>V	A:83	(129.05, 23.54, 37.91)
15:90349561		Y>C	A:85	(127.22, 17.16, 34.36)
15:90349558	rs25653	R>Q	A:86	(133.67, 13.80, 33.57)
15:90349552	rs569385341 COSM2156888	T>M	A:88	(131.16, 7.85, 29.06)
15:90349543	rs372186369	P>L	A:91	(126.12, 1.78, 22.71)
15:90349528		N>S	A:96	(122.25, -9.84, 25.72)
15:90349524	rs375180451	D>E	A:97	(122.96, -13.64, 26.60)
15:90349523		R>G	A:98	(118.05, -12.10, 29.77)
15:90349519		G>D	A:99	(117.97, -10.00, 24.44)
15:90349511		V>I	A:102	(122.68, -2.76, 26.86)
15:90349508	rs368883377	F>L	A:103	(122.96, 2.22, 28.41)
15:90349490	rs150675107	V>I	A:109	(128.86, 15.68, 38.83)
15:90349486		R>H	A:110	(132.75, 20.06, 38.92)
15:90349487	rs140990496	R>C	A:110	(132.75, 20.06, 38.92)
15:90349471		E>G	A:115	(121.64, 25.13, 52.02)
15:90349460	rs370969705	V>I	A:119	(121.52, 14.81, 51.11)
15:90349449	rs544815907	I>M	A:122	(120.83, 13.13, 41.65)
15:90349423		L>P	A:131	(129.19, -1.12, 43.90)
15:90349396	rs145360414	R>H	A:140	(136.02, 13.27, 43.95)
15:90349397	COSM4057834	R>C	A:140	(136.02, 13.27, 43.95)
15:90349391		V>M	A:142	(136.90, 20.47, 44.58)
15:90349376		P>S	A:147	(134.00, 15.27, 51.45)
15:90349348	rs370927385	V>A	A:156	(113.47, 6.98, 45.30)
15:90349339	rs570722845	T>I	A:159	(110.92, 10.87, 42.90)
15:90349337	rs376358699 COSM3505356	E>K	A:160	(112.51, 9.45, 38.75)
15:90349309		S>F	A:169	(127.33, 18.35, 56.29)
15:90349286		E>K	A:177	(133.88, 15.97, 41.61)
15:90349279	rs147870602	D>V	A:179	(132.42, 9.61, 40.50)
15:90349277	COSM250837	S>G	A:180	(128.97, 7.27, 38.17)
15:90349258		L>S	A:186	(119.27, 0.72, 24.15)
15:90349255		A>V	A:187	(114.91, 0.55, 24.62)
15:90349250	rs527736294	D>N	A:189	(111.43, 3.40, 25.09)
15:90349235		Y>H	A:194	(115.70, 5.85, 21.53)
15:90349231		R>H	A:195	(116.04, -0.42, 20.54)
15:90349232	rs201704361 COSM1375381	R>C	A:195	(116.04, -0.42, 20.54)
15:90349220		M>L	A:199	(115.66, -3.50, 7.38)
15:90349210		N>S	A:202	(117.51, -8.90, 4.27)
15:90349208		V>I	A:203	(120.61, -5.99, 6.95)
15:90349201		K>R	A:205	(120.99, -1.62, 10.00)
15:90348693		V>M	A:206	(120.52, -0.92, 15.35)
15:90348690	rs371453193	V>M	A:207	(120.12, 3.48, 15.85)
15:90348683		T>I	A:209	(118.89, 7.68, 19.67)
15:90348668		A>V	A:214	(111.37, 16.43, 29.76)
15:90348656	COSM1183061	R>Q	A:218	(115.76, 11.84, 35.04)
15:90348653		K>T	A:219	(116.20, 6.66, 30.89)
15:90348629		P>L	A:227	(115.34, 23.25, 33.33)
15:90348622		M>I	A:229	(119.83, 22.76, 37.36)
15:90348624		M>L	A:229	(119.83, 22.76, 37.36)
15:90348615	rs375160446	E>K	A:232	(129.41, 23.27, 31.25)
15:90348605		I>S	A:235	(129.87, 13.92, 25.72)
15:90348592		H>Q	A:239	(131.79, 4.12, 18.52)
15:90348552		G>S	A:253	(139.38, 15.10, 17.94)
15:90348446	rs370085507	P>A	A:254	(140.73, 12.22, 16.57)
15:90348437		P>T	A:257	(141.34, 3.01, 19.05)
15:90348434	rs146926671	L>I	A:258	(138.69, 0.69, 22.97)
15:90348417		N>K	A:263	(136.20, -4.15, 17.18)
15:90348419		N>D	A:263	(136.20, -4.15, 17.18)
15:90348409		V>A	A:266	(136.67, 6.51, 21.64)
15:90348391		T>M	A:272	(128.50, 22.03, 26.07)
15:90348392		T>S	A:272	(128.50, 22.03, 26.07)
15:90348385	rs368070845	K>R	A:274	(125.46, 27.23, 31.02)
15:90348376		T>M	A:277	(119.59, 18.17, 30.88)
15:90348358		I>T	A:283	(123.22, 9.78, 17.65)
15:90348348		E>D	A:286	(125.38, 2.99, 8.86)
15:90348344	rs370685507	D>N	A:288	(124.87, 8.88, 4.85)
15:90348338		V>M	A:290	(123.68, 16.34, 2.73)
15:90348335	rs138545632	E>K	A:291	(127.83, 19.21, 3.77)
15:90348326		A>T	A:294	(125.63, 28.82, 6.19)
15:90348319		N>S	A:296	(125.82, 32.03, 9.65)
15:90347844	rs566665242	R>Q	A:301	(126.26, 17.78, 9.30)
15:90347832	rs373113395	R>Q	A:305	(117.01, 5.27, 6.06)
15:90347833		R>W	A:305	(117.01, 5.27, 6.06)
15:90347825		S>R	A:307	(118.49, 5.21, 1.08)
15:90347820	rs368916420	I>T	A:309	(120.75, 10.84, 1.74)
15:90347814	rs17240268	A>V	A:311	(117.49, 9.72, -3.16)
15:90347808		H>L	A:313	(114.60, 11.75, -0.38)
15:90347809	rs141811394	H>D	A:313	(114.60, 11.75, -0.38)
15:90347806	rs148047449	G>S	A:314	(117.54, 16.00, 1.96)
15:90347800		Y>H	A:316	(112.91, 21.46, 1.06)
15:90347788		V>M	A:320	(115.33, 25.42, 4.14)
15:90347784	rs8179199	T>M	A:321	(118.09, 24.71, 7.41)
15:90347769		N>I	A:326	(120.90, 33.77, 8.55)
15:90347767	rs200899610	F>L	A:327	(115.11, 35.19, 9.15)
15:90347761		A>S	A:329	(120.06, 35.72, 13.48)
15:90347754	rs201350251	H>R	A:331	(113.93, 39.11, 12.94)
15:90347633	rs201835756	I>V	A:344	(119.13, 13.33, 12.48)
15:90347618		F>L	A:349	(111.20, 10.81, 17.25)
15:90347612	rs367926309	A>T	A:351	(107.53, 13.33, 18.36)
15:90347609		G>S	A:352	(108.36, 15.27, 15.53)
15:90347594		W>G	A:357	(122.22, 24.56, 21.98)
15:90347582		T>A	A:361	(115.93, 15.10, 16.40)
15:90347578		Y>S	A:362	(113.90, 16.43, 12.53)
15:90347575	rs141631662	R>Q	A:363	(108.37, 11.30, 13.37)
15:90347576	rs147069406	R>W	A:363	(108.37, 11.30, 13.37)
15:90347555	rs147889608	D>N	A:370	(110.01, 12.47, -2.83)
15:90347535		S>R	A:376	(102.36, 20.25, -0.94)
15:90347533		S>T	A:377	(101.21, 19.20, 3.04)
15:90347534	rs550682152	S>G	A:377	(101.21, 19.20, 3.04)
15:90347521		R>Q	A:381	(105.22, 18.23, 9.02)
15:90347505	rs367852979	I>M	A:386	(113.02, 22.84, 9.94)
15:90347498		E>K	A:389	(112.89, 22.62, 16.12)
15:90347487	COSM702154	H>Q	A:392	(112.94, 25.95, 20.23)
15:90347485		Q>R	A:393	(118.23, 26.79, 18.65)
15:90347227		G>R	A:396	(115.19, 27.42, 24.77)
15:90347224		N>D	A:397	(118.20, 26.15, 23.42)
15:90347211		I>T	A:401	(111.82, 27.34, 30.60)
15:90347201		W>C	A:404	(109.22, 21.98, 32.06)
15:90347182	COSM966414	E>K	A:411	(107.07, 25.09, 22.46)
15:90347173	rs183757710	A>T	A:414	(108.19, 28.22, 18.20)
15:90347164	rs373183009	V>M	A:417	(108.97, 32.15, 15.11)
15:90347148	rs144282919	A>G	A:422	(108.63, 29.53, 6.61)
15:90347142		Y>C	A:424	(113.67, 33.84, 4.37)
15:90347139		A>V	A:425	(111.74, 30.09, 2.64)
15:90347016		D>E	A:433	(97.42, 34.14, 6.60)
15:90347011		M>R	A:435	(98.73, 31.72, 12.46)
15:90347000	rs555461349	D>N	A:439	(97.38, 28.04, 15.96)
15:90346993	rs371985741	Y>C	A:441	(89.61, 30.06, 15.13)
15:90346990	rs142936100	R>H	A:442	(94.67, 23.89, 17.72)
15:90346991		R>C	A:442	(94.67, 23.89, 17.72)
15:90346981		A>V	A:445	(88.10, 24.71, 21.71)
15:90346954	rs200722247	P>L	A:454	(96.56, 29.14, 32.53)
15:90346943		P>T	A:458	(100.57, 27.99, 38.81)
15:90346936		S>L	A:460	(102.86, 24.93, 42.55)
15:90346927		N>I	A:463	(105.36, 19.02, 40.63)
15:90346924		T>M	A:464	(104.68, 15.23, 38.03)
15:90346925		T>A	A:464	(104.68, 15.23, 38.03)
15:90346913		I>F	A:468	(105.78, 18.23, 32.97)
15:90346897	rs553551016	D>G	A:473	(99.07, 21.90, 25.52)
15:90346894		A>V	A:474	(97.20, 23.79, 22.74)
15:90346895		A>T	A:474	(97.20, 23.79, 22.74)
15:90346881	rs371398651	S>R	A:478	(98.49, 27.44, 19.76)
15:90346882		S>T	A:478	(98.49, 27.44, 19.76)
15:90346699	rs528646801 COSM1708535	E>K	A:493	(107.71, 42.05, 14.46)
15:90346693	rs187980947	V>I	A:495	(108.71, 47.08, 18.56)
15:90346682	rs531194148	Q>H	A:498	(113.65, 46.61, 19.83)
15:90346526	rs201577768	H>Y	A:505	(121.13, 40.22, 23.67)
15:90346522		T>I	A:506	(119.81, 39.84, 29.18)
15:90346510		Q>R	A:510	(120.59, 33.02, 31.99)
15:90346507		N>S	A:511	(116.70, 30.24, 32.97)
15:90346498		Y>C	A:514	(105.36, 35.75, 33.70)
15:90346496		L>V	A:515	(107.41, 38.90, 34.69)
15:90344838		A>S	A:524	(110.94, 48.99, 23.47)
15:90344827	rs201349020	N>K	A:527	(113.28, 53.18, 23.81)
15:90344829		N>D	A:527	(113.28, 53.18, 23.81)
15:90344825		R>Q	A:528	(110.23, 52.61, 19.07)
15:90344826		R>W	A:528	(110.23, 52.61, 19.07)
15:90344816		Q>L	A:531	(101.90, 55.95, 24.83)
15:90344805	COSM3817036	T>P	A:535	(102.09, 48.23, 31.47)
15:90344802		V>M	A:536	(103.39, 45.19, 28.46)
15:90344798		R>Q	A:537	(104.15, 43.24, 34.17)
15:90344795	rs540893220	D>G	A:538	(99.28, 45.10, 33.52)
15:90344783	rs370456207	R>H	A:542	(94.28, 41.19, 32.11)
15:90344784	rs145940069	R>C	A:542	(94.28, 41.19, 32.11)
15:90344777		T>I	A:544	(99.36, 34.84, 30.61)
15:90344769		M>V	A:547	(91.39, 30.27, 31.83)
15:90344759		P>L	A:550	(87.23, 37.39, 25.17)
15:90344750	rs371639363	T>M	A:553	(79.16, 41.84, 22.13)
15:90344735		T>M	A:558	(74.57, 52.09, 20.52)
15:90344732	rs377108670	G>E	A:559	(78.35, 51.45, 20.02)
15:90344721	rs373181522	Q>E	A:563	(84.66, 42.12, 28.01)
15:90344717	rs546399148 COSM3505344	E>G	A:564	(81.24, 37.52, 28.38)
15:90344700		P>A	A:570	(76.66, 28.28, 29.76)
15:90344690		N>S	A:573	(81.67, 25.63, 37.45)
15:90344682		R>C	A:576	(92.02, 28.02, 37.82)
15:90344676	rs376697775	S>A	A:578	(91.06, 35.50, 38.25)
15:90344413		V>A	A:583	(88.54, 41.26, 32.61)
15:90344414	rs201255326	V>M	A:583	(88.54, 41.26, 32.61)
15:90344386	rs572194006	R>K	A:592	(82.57, 51.54, 9.03)
15:90344374		Q>R	A:596	(91.52, 49.59, 8.89)
15:90344352	rs8192297	I>M	A:603	(89.92, 48.92, 29.37)
15:90344353	rs17240212	I>K	A:603	(89.92, 48.92, 29.37)
15:90344348	rs140909814	V>I	A:605	(83.04, 44.93, 30.80)
15:90342773		S>G	A:613	(77.95, 53.06, 15.20)
15:90342769		T>I	A:614	(75.89, 51.46, 12.23)
15:90342752	rs143245843	V>L	A:620	(80.99, 46.87, 11.39)
15:90342730	rs149131671	T>M	A:627	(95.22, 39.79, 15.01)
15:90342718	COSM966407	R>Q	A:631	(85.44, 33.65, 19.19)
15:90342712		N>I	A:633	(78.39, 38.71, 18.74)
15:90342707		D>N	A:635	(73.57, 43.47, 16.10)
15:90342699		E>D	A:637	(70.57, 45.11, 11.90)
15:90342691	rs538081784	R>K	A:640	(69.98, 40.54, 9.59)
15:90342681		Q>H	A:643	(74.15, 37.10, 6.28)
15:90342683		Q>K	A:643	(74.15, 37.10, 6.28)
15:90342674	rs558022364	L>M	A:646	(78.56, 36.99, 2.25)
15:90342658	rs8179192	S>L	A:651	(85.20, 39.93, -2.16)
15:90342537		V>L	A:655	(89.78, 35.58, 3.40)
15:90342533		I>T	A:656	(91.15, 35.84, 7.44)
15:90342530		N>S	A:657	(87.41, 38.25, 8.50)
15:90342531		N>H	A:657	(87.41, 38.25, 8.50)
15:90342518		I>S	A:661	(81.89, 35.39, 9.86)
15:90342516		I>V	A:662	(82.01, 30.69, 9.39)
15:90340927	rs373325407	A>V	A:679	(75.51, 29.79, 11.61)
15:90340918	rs369054571	N>S	A:682	(77.04, 32.51, 8.02)
15:90340890		Q>H	A:691	(89.71, 31.17, -1.24)
15:90340877		E>K	A:696	(89.20, 24.18, 6.78)
15:90340871		A>T	A:698	(83.32, 25.26, 7.90)
15:90340852		Y>C	A:704	(80.01, 19.66, 17.61)
15:90340853		Y>H	A:704	(80.01, 19.66, 17.61)
15:90340846		K>R	A:706	(80.52, 14.08, 11.63)
15:90340832	COSM1189098	R>C	A:711	(76.01, 8.01, 16.46)
15:90340828		S>F	A:712	(71.50, 10.81, 13.41)
15:90340826	COSM3505341	E>K	A:713	(67.05, 11.91, 12.17)
15:90340814		P>A	A:717	(70.04, 15.86, 5.92)
15:90336321		H>Y	A:732	(86.54, 25.17, -10.50)
15:90336266		Q>R	A:750	(97.52, 23.12, -4.10)
15:90335788	rs25651	S>N	A:752	(90.71, 24.11, -2.02)
15:90335785		E>G	A:753	(91.92, 20.35, -5.42)
15:90335786	rs1803098	E>K	A:753	(91.92, 20.35, -5.42)
15:90335765		A>T	A:760	(82.38, 15.41, -2.35)
15:90335755	COSM1517865	N>S	A:763	(78.98, 14.51, 1.65)
15:90335753	rs8179195	G>R	A:764	(77.89, 12.03, -2.47)
15:90335747	rs148410109	P>S	A:766	(78.28, 11.18, -7.90)
15:90335743		E>A	A:767	(80.52, 13.19, -10.29)
15:90335730		M>I	A:771	(87.69, 10.39, -9.28)
15:90335723	rs374584607	G>S	A:774	(89.26, 4.63, -10.71)
15:90335720		L>V	A:775	(92.31, 7.05, -9.89)
15:90335702	rs149334449	E>Q	A:781	(94.76, -2.47, -13.02)
15:90335698		N>S	A:782	(99.17, -0.22, -13.02)
15:90335696	rs371057081 COSM3505338	P>S	A:783	(101.20, -1.46, -8.99)
15:90335683	rs201639683 COSM1608822	P>L	A:787	(97.80, 7.20, -11.04)
15:90335684		P>T	A:787	(97.80, 7.20, -11.04)
15:90335550	rs373190710	P>R	A:790	(100.96, 13.32, -4.53)
15:90335545		L>M	A:792	(94.78, 13.90, -4.65)
15:90335541		R>Q	A:793	(98.94, 9.68, -3.42)
15:90335542		R>W	A:793	(98.94, 9.68, -3.42)
15:90335533	rs369616479	V>I	A:796	(91.94, 8.82, -3.36)
15:90335514	rs147195383	A>V	A:802	(85.12, 3.23, 1.64)
15:90335508	rs200088948	G>V	A:804	(85.04, -0.85, -1.05)
15:90335505		G>V	A:805	(86.88, -3.77, -0.17)
15:90335506		G>R	A:805	(86.88, -3.77, -0.17)
15:90335500	COSM3505336	E>K	A:807	(89.55, -7.00, -3.32)
15:90335490		D>V	A:810	(94.04, -6.66, 1.21)
15:90335491	rs143594116	D>N	A:810	(94.04, -6.66, 1.21)
15:90335485	COSM278877	A>T	A:812	(96.80, -1.01, 0.89)
15:90335476		Q>K	A:815	(101.50, -0.95, -1.34)
15:90335469		R>Q	A:817	(103.61, -5.06, 5.45)
15:90335458		L>V	A:821	(108.41, 7.43, 2.33)
15:90335437		L>V	A:828	(98.45, 3.74, 2.89)
15:90335433	rs375147227	R>Q	A:829	(99.00, 4.79, 9.21)
15:90335434	rs200752447	R>W	A:829	(99.00, 4.79, 9.21)
15:90335410		E>K	A:837	(83.20, -3.82, 6.70)
15:90335399	COSM3505334	I>M	A:840	(88.13, -4.77, 8.13)
15:90334320		L>M	A:845	(92.58, -2.36, 16.70)
15:90334311		T>A	A:848	(97.67, -1.00, 16.16)
15:90334301		P>L	A:851	(105.46, -4.08, 17.00)
15:90334291		I>M	A:854	(102.01, -0.59, 13.17)
15:90334289		R>Q	A:855	(107.82, 1.65, 13.07)
15:90334290	rs369201239 COSM1375371	R>W	A:855	(107.82, 1.65, 13.07)
15:90334275		T>A	A:860	(98.10, 5.91, 19.33)
15:90334263		I>F	A:864	(93.01, 8.36, 16.84)
15:90334250		N>S	A:868	(87.84, 9.48, 13.82)
15:90334245		V>I	A:870	(81.00, 5.92, 12.54)
15:90334230		L>V	A:875	(85.96, -0.94, 18.17)
15:90334227		V>I	A:876	(88.01, 2.29, 20.03)
15:90334215		V>L	A:880	(89.83, 2.28, 25.83)
15:90334210	rs200383502 COSM702157	Q>H	A:881	(86.02, 0.94, 28.43)
15:90334203	rs376323078	W>R	A:884	(93.54, 3.41, 30.50)
15:90334185		D>N	A:890	(102.86, -0.14, 27.19)
15:90333770		Y>C	A:891	(100.85, 1.73, 23.72)
15:90333728		V>A	A:905	(87.30, 8.07, 22.22)
15:90328726	rs375796125	Q>K	A:920	(82.26, 3.58, 35.94)
15:90328693	rs370461277	G>S	A:931	(98.29, 11.17, 33.56)
15:90328684		T>A	A:934	(94.28, 14.01, 33.98)
15:90328680	rs199983054	R>Q	A:935	(93.29, 19.48, 32.67)
15:90328681	rs141333670	R>W	A:935	(93.29, 19.48, 32.67)
15:90328677		A>G	A:936	(91.40, 15.39, 29.11)
15:90328674		L>P	A:937	(88.94, 12.67, 31.79)
15:90328671	rs201340495	E>G	A:938	(88.07, 16.28, 34.02)
15:90328659		E>G	A:942	(83.12, 20.44, 30.45)
15:90328653	rs376373199 COSM434525	T>K	A:944	(79.82, 14.87, 27.44)
15:90328615	rs529463540	V>M	A:957	(66.66, 23.45, 14.38)
15:90328594		E>K	A:964	(64.08, 23.83, 5.04)

4FYS.A | ANPEP.

4FYS.A | ANPEP

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:90349558	COSM4984858	R>Q	A:86	(133.67, 13.80, 33.57)
15:90349552	COSM2156888	T>M	A:88	(131.16, 7.85, 29.06)
15:90349531	COSM1375384	P>H	A:95	(121.51, -8.71, 21.13)
15:90349355	COSM416768	E>Q	A:154	(117.93, 5.55, 48.81)
15:90349236	COSM1608823	F>L	A:193	(120.90, 6.03, 24.84)
15:90349232	COSM1375381	R>C	A:195	(116.04, -0.42, 20.54)
15:90347724	COSM3505350	S>L	A:341	(123.03, 22.46, 12.90)
15:90347169	COSM137027	S>F	A:415	(104.60, 28.06, 17.26)
15:90346926	COSM3387147	N>K	A:463	(105.36, 19.02, 40.63)
15:90346921	COSM2139621	P>L	A:465	(106.66, 13.70, 35.20)
15:90346534	COSM1678676	S>F	A:502	(116.93, 42.70, 25.02)
15:90344825	COSM2139615	R>Q	A:528	(110.23, 52.61, 19.07)
15:90344713	COSM255744	H>Q	A:565	(85.10, 33.54, 30.15)
15:90344681	COSM254533	R>H	A:576	(92.02, 28.02, 37.82)
15:90344352	COSM4128568	I>M	A:603	(89.92, 48.92, 29.37)
15:90342782	COSM3505343	D>N	A:610	(80.76, 56.62, 17.48)
15:90342704	COSM172920	E>K	A:636	(70.51, 39.19, 15.04)
15:90342528	COSM3690609	R>W	A:658	(85.58, 35.30, 3.56)
15:90342517	COSM1678675	I>M	A:661	(81.89, 35.39, 9.86)
15:90342507	COSM2139610	A>T	A:665	(78.84, 31.70, 14.76)
15:90340832	COSM1189098	R>C	A:711	(76.01, 8.01, 16.46)
15:90336311	COSM2139606	N>T	A:735	(87.43, 22.53, -15.98)
15:90335683	COSM1608822	P>L	A:787	(97.80, 7.20, -11.04)
15:90334210	COSM702157	Q>H	A:881	(86.02, 0.94, 28.43)