Assessment of Structural Intolerance and Durability
General Structure Information 2y7j PHKG2 structure of human phosphorylase kinase, gamma 2 2.5Å AUTH J.R.C.MUNIZ,A.SHRESTHA,P.SAVITSKY,J.WANG,P.RELLOS,O.FEDOROV,AUTH 2 N.BURGESS-BROWN,B.BRENNER,G.BERRIDGE,J.M.ELKINS,T.KROJER,AUTH 3 M.VOLLMAR,K.H.CHE,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 4 J.WEIGELT,C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1h66 NQO1 crystal structure of human nad[p]h-quinone oxidoreductase co with 2,5-diaziridinyl-3-hydroxyl-6-methyl-1,4-benzoquinone 2.0Å AUTH M.FAIG,M.A.BIANCHET,S.WINSKI,R.HARGREAVES,C.J.MOODY,AUTH 2 A.R.HUDNOTT,D.ROSS,L.M.AMZELTITL STRUCTURE-BASED DEVELOPMENT OF ANTICANCER DRUGS: COMPLEXESTITL 2 OF NAD(P)H:QUINONE OXIDOREDUCTASE 1 WITH CHEMOTHERAPEUTICTITL 3 QUINONESREF STRUCTURE V. 9 659 2001REFN ISSN 0969-2126PMID 11587640DOI 10.1016/S0969-2126(01)00636-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2w2v RAC2 rac2 (g12v) in complex with gtpgs 2.0Å AUTH T.D.BUNNEY,O.OPALEYE,S.M.ROE,P.VATTER,AUTH 2 R.W.BAXENDALE,C.WALLISER,K.L.EVERETT,M.B.JOSEPHS,AUTH 3 C.CHRISTOW,F.RODRIGUES-LIMA,P.GIERSCHIK,L.H.PEARL,AUTH 4 M.KATANTITL STRUCTURAL INSIGHTS INTO FORMATION OF AN ACTIVETITL 2 SIGNALING COMPLEX BETWEEN RAC AND PHOSPHOLIPASE CTITL 3 GAMMA 2.REF MOL.CELL V. 34 223 2009REFN ISSN 1097-2765PMID 19394299DOI 10.1016/J.MOLCEL.2009.02.023 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4bqa ETS2 crystal structure of the ets domain of human ets2 in complex with dna 2.5Å AUTH J.A.NEWMAN,C.D.O.COOPER,H.AITKENHEAD,O.GILEADITITL STRUCTURAL INSIGHTS INTO THE AUTOREGULATION ANDTITL 2 COOPERATIVITY OF THE HUMAN TRANSCRIPTION FACTOR ETS-2.REF J.BIOL.CHEM. V. 290 8539 2015REFN ISSN 0021-9258PMID 25670864DOI 10.1074/JBC.M114.619270 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1cvj PABPC1 x-ray crystal structure of the poly(a)-binding protein in complex with polyadenylate rna 2.6Å AUTH R.C.DEO,J.B.BONANNO,N.SONENBERG,S.K.BURLEYTITL RECOGNITION OF POLYADENYLATE RNA BY THETITL 2 POLY(A)-BINDING PROTEIN.REF CELL(CAMBRIDGE,MASS.) V. 98 835 1999REFN ISSN 0092-8674PMID 10499800DOI 10.1016/S0092-8674(00)81517-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qa9 CD58 structure of a heterophilic adhesion complex between the human cd2 and cd58(lfa-3) counter-receptors 3.2Å AUTH J.H.WANG,A.SMOLYAR,K.TAN,J.H.LIU,M.KIM,Z.Y.SUN,AUTH 2 G.WAGNER,E.L.REINHERZTITL STRUCTURE OF A HETEROPHILIC ADHESION COMPLEXTITL 2 BETWEEN THE HUMAN CD2 AND CD58 (LFA-3)TITL 3 COUNTERRECEPTORS.REF CELL(CAMBRIDGE,MASS.) V. 97 791 1999REFN ISSN 0092-8674PMID 10380930DOI 10.1016/S0092-8674(00)80790-4 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2xsx ENO3 crystal structure of human beta enolase enob 1.7Å AUTH M.VOLLMAR,E.KRYSZTOFINSKA,A.CHAIKUAD,T.KROJER,R.COCKING,AUTH 2 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 W.W.YUE,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA ENOLASE ENOBREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1esl SELE insight into e-selectin(slash)ligand interaction from the crystal structure and mutagenesis of the lec(slash)egf domains 2.0Å AUTH B.J.GRAVES,R.L.CROWTHER,C.CHANDRAN,J.M.RUMBERGER,AUTH 2 S.LI,K.S.HUANG,D.H.PRESKY,P.C.FAMILLETTI,AUTH 3 B.A.WOLITZKY,D.K.BURNSTITL INSIGHT INTO E-SELECTIN/LIGAND INTERACTION FROMTITL 2 THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THETITL 3 LEC/EGF DOMAINS.REF NATURE V. 367 532 1994REFN ISSN 0028-0836PMID 7509040DOI 10.1038/367532A0 Variant Set Distributions Ripley’s […]
General Structure Information 1z6x ARF4 structure of human adp-ribosylation factor 4 2.7Å AUTH A.ATANASSOVA,J.CHOE,C.ARROWSMITH,A.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1n11 ANK1 d34 region of human ankyrin-r and linker 2.7Å AUTH P.MICHAELY,D.R.TOMCHICK,M.MACHIUS,R.G.W.ANDERSONTITL CRYSTAL STRUCTURE OF A 12 ANK REPEAT STACK FROMTITL 2 HUMAN ANKYRINRREF EMBO J. V. 21 6387 2002REFN ISSN 0261-4189PMID 12456646DOI 10.1093/EMBOJ/CDF651 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants