Assessment of Structural Intolerance and Durability
General Structure Information 1itb IL1R1 type-1 interleukin-1 receptor complexed with interleukin-1 beta 2.5Å AUTH G.P.VIGERS,L.J.ANDERSON,P.CAFFES,B.J.BRANDHUBERTITL CRYSTAL STRUCTURE OF THE TYPE-I INTERLEUKIN-1TITL 2 RECEPTOR COMPLEXED WITH INTERLEUKIN-1BETA.REF NATURE V. 386 190 1997REFN ISSN 0028-0836PMID 9062193DOI 10.1038/386190A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gd7 CFTR crystal structure of human nbd2 complexed with n6- phenylethyl-atp (p-atp) 2.7Å AUTH S.ATWELL,S.ANTONYSAMY,W.B.GUGGINO,K.CONNERS,AUTH 2 S.EMTAGE,T.GHEYI,J.F.HUNT,H.A.LEWIS,F.LU,AUTH 3 J.M.SAUDER,P.C.WEBER,D.WETMORE,X.ZHAOTITL CRYSTAL STRUCTURE OF HUMAN NBD2 COMPLEXED WITHTITL 2 N6-PHENYLETHYL-ATP (P-ATP)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3g04 TSHR crystal structure of the tsh receptor in complex with a thyroid- stimulating autoantibody 2.55Å AUTH J.SANDERS,D.Y.CHIRGADZE,P.SANDERS,S.BAKER,A.SULLIVAN,AUTH 2 A.BHARDWAJA,J.BOLTON,M.REEVE,N.NAKATAKE,M.EVANS,T.RICHARDS,AUTH 3 M.POWELL,R.N.MIGUEL,T.L.BLUNDELL,J.FURMANIAK,B.R.SMITHTITL CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH ATITL 2 THYROID-STIMULATING AUTOANTIBODYREF THYROID V. 17 395 2007REFN ISSN 1050-7256PMID 17542669DOI 10.1089/THY.2007.0034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ksr CHRNB2 nmr structures of tm domain of the n-acetylcholine receptor b2 subunit -1.0Å AUTH V.BONDARENKO,T.TILLMAN,Y.XU,P.TANGTITL NMR STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THETITL 2 N-ACETYLCHOLINE RECEPTOR BETA2 SUBUNIT.REF BIOCHIM.BIOPHYS.ACTA V.1798 1608 2010REFN ISSN 0006-3002PMID 20441771DOI 10.1016/J.BBAMEM.2010.04.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3se4 IFNAR1 human ifnw-ifnar ternary complex 3.5Å AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1fd0 RARG isotype selectivity of the human retinoic acid nuclear receptor hrar: the complex with the rargamma-selective retinoid sr11254 1.38Å AUTH B.KLAHOLZ,D.MORASTITL C-H…O HYDROGEN BONDS IN THE NUCLEAR RECEPTORTITL 2 RARGAMMA–A POTENTIAL TOOL FOR DRUG SELECTIVITY.REF STRUCTURE V. 10 1197 2002REFN ISSN 0969-2126PMID 12220491DOI 10.1016/S0969-2126(02)00828-6 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2bb5 TCN2 structure of human transcobalamin in complex with cobalamin 3.2Å AUTH J.WUERGES,G.GARAU,S.GEREMIA,S.N.FEDOSOV,T.E.PETERSEN,AUTH 2 L.RANDACCIOTITL STRUCTURAL BASIS FOR MAMMALIAN VITAMIN B12 TRANSPORT BYTITL 2 TRANSCOBALAMIN.REF PROC.NATL.ACAD.SCI.USA V. 103 4386 2006REFN ISSN 0027-8424PMID 16537422DOI 10.1073/PNAS.0509099103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1rw2 XRCC5 three-dimensional structure of ku80 ctd -1.0Å AUTH Z.ZHANG,W.HU,L.CANO,T.D.LEE,D.J.CHEN,Y.CHENTITL SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OFTITL 2 KU80 SUGGESTS IMPORTANT SITES FOR PROTEIN-PROTEINTITL 3 INTERACTIONS.REF STRUCTURE V. 12 495 2004REFN ISSN 0969-2126PMID 15016365DOI 10.1016/J.STR.2004.02.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3uiu EIF2AK2 crystal structure of apo-pkr kinase domain 2.9Å AUTH F.LI,S.LI,X.YANG,Y.SHEN,T.ZHANGTITL CRYSTAL STRUCTURE OF APO-PKR KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1itv MMP9 dimeric form of the haemopexin domain of mmp9 1.95Å AUTH H.CHA,E.KOPETZKI,R.HUBER,M.LANZENDORFER,AUTH 2 H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE ADAPTIVE MOLECULARTITL 2 RECOGNITION BY MMP9.REF J.MOL.BIOL. V. 320 1065 2002REFN ISSN 0022-2836PMID 12126625DOI 10.1016/S0022-2836(02)00558-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants