Assessment of Structural Intolerance and Durability
General Structure Information 1rn7 CST5 structure of human cystatin d 2.5Å AUTH M.ALVAREZ-FERNANDEZ,Y.H.LIANG,M.ABRAHAMSON,X.D.SUTITL CRYSTAL STRUCTURE OF HUMAN CYSTATIN D, A CYSTEINETITL 2 PEPTIDASE INHIBITOR WITH RESTRICTED INHIBITIONTITL 3 PROFILE.REF J.BIOL.CHEM. V. 280 18221 2005REFN ISSN 0021-9258PMID 15728581DOI 10.1074/JBC.M411914200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mqb EPHA2 crystal structure of ephrin a2 (epha2) receptor protein kinase 2.3Å AUTH J.NOWAKOWSKI,C.N.CRONIN,D.E.MCREE,M.W.KNUTH,AUTH 2 C.NELSON,N.PAVLETICH,J.ROGERS,B.C.SANG,D.N.SCHEIBE,AUTH 3 R.V.SWANSON,D.A.THOMPSONTITL STRUCTURES OF THE CANCER RELATED AURORA-A, FAK ANDTITL 2 EPHA2 PROTEIN KINASES FROM NANOVOLUMETITL 3 CRYSTALLOGRAPHYREF STRUCTURE V. 10 1659 2003REFN ISSN 0969-2126PMID 12467573DOI 10.1016/S0969-2126(02)00907-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3bpo IL4R crystal structure of the il13-il4r-il13ra ternary complex 3.0Å AUTH S.L.LAPORTE,Z.S.JUO,J.VACLAVIKOVA,L.A.COLF,X.QI,N.M.HELLER,AUTH 2 A.D.KEEGAN,K.C.GARCIATITL MOLECULAR AND STRUCTURAL BASIS OF CYTOKINE RECEPTORTITL 2 PLEIOTROPY IN THE INTERLEUKIN-4/13 SYSTEM.REF CELL(CAMBRIDGE,MASS.) V. 132 259 2008REFN ISSN 0092-8674PMID 18243101DOI 10.1016/J.CELL.2007.12.030 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2koe CNR1 human cannabinoid receptor 1 – helix 7/8 peptide -1.0Å AUTH S.TYUKHTENKO,E.K.TIBURU,L.DESHMUKH,O.VINOGRADOVA,AUTH 2 D.R.JANERO,A.MAKRIYANNISTITL NMR SOLUTION STRUCTURE OF HUMAN CANNABINOIDTITL 2 RECEPTOR-1 HELIX 7/8 PEPTIDE: CANDIDATETITL 3 ELECTROSTATIC INTERACTIONS AND MICRODOMAINTITL 4 FORMATION.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 390 441 2009REFN ISSN 0006-291XPMID 19766594DOI 10.1016/J.BBRC.2009.09.053 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3ua5 CYP2B6 crystal structure of p450 2b6 (y226h/k262r) in complex with two molecules of amlodipine 2.8Å AUTH M.B.SHAH,P.R.WILDERMAN,J.PASCUAL,Q.ZHANG,C.D.STOUT,AUTH 2 J.R.HALPERTTITL CONFORMATIONAL ADAPTATION OF HUMAN CYTOCHROME P450 2B6 ANDTITL 2 RABBIT CYTOCHROME P450 2B4 REVEALED UPON BINDING MULTIPLETITL 3 AMLODIPINE MOLECULES.REF BIOCHEMISTRY V. 51 7225 2012REFN ISSN 0006-2960PMID 22909231DOI 10.1021/BI300894Z Variant Set Distributions […]
General Structure Information 2qnj MARK3 kinase and ubiquitin-associated domains of mark3/par-1 2.7Å AUTH J.M.MURPHY,D.M.KORZHNEV,D.F.CECCARELLI,D.J.BRIANT,AUTH 2 A.ZARRINE-AFSAR,F.SICHERI,L.E.KAY,T.PAWSONTITL CONFORMATIONAL INSTABILITY OF THE MARK3 UBA DOMAINTITL 2 COMPROMISES UBIQUITIN RECOGNITION AND PROMOTES INTERACTIONTITL 3 WITH THE ADJACENT KINASE DOMAINREF PROC.NATL.ACAD.SCI.USA V. 104 14336 2007REFN ISSN 0027-8424PMID 17726107DOI 10.1073/PNAS.0703012104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2yd6 PTPRD crystal structure of the n-terminal ig1-2 module of human receptor protein tyrosine phosphatase delta 1.35Å AUTH C.H.COLES,Y.SHEN,A.P.TENNEY,C.SIEBOLD,G.C.SUTTON,W.LU,AUTH 2 J.T.GALLAGHER,E.Y.JONES,J.G.FLANAGAN,A.R.ARICESCUTITL PROTEOGLYCAN-SPECIFIC MOLECULAR SWITCH FOR RPTP SIGMATITL 2 CLUSTERING AND NEURONAL EXTENSION.REF SCIENCE V. 332 484 2011REFN ISSN 0036-8075PMID 21454754DOI 10.1126/SCIENCE.1200840 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1fxl ELAVL4 crystal structure of hud and au-rich element of the c-fos rna 1.8Å AUTH X.WANG,T.M.TANAKA HALLTITL STRUCTURAL BASIS FOR RECOGNITION OF AU-RICHTITL 2 ELEMENT RNA BY THE HUD PROTEIN.REF NAT.STRUCT.BIOL. V. 8 141 2001REFN ISSN 1072-8368PMID 11175903DOI 10.1038/84131 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3pta DNMT1 crystal structure of human dnmt1(646-1600) in complex with dna 3.6Å AUTH J.SONG,O.RECHKOBLIT,T.H.BESTOR,D.J.PATELTITL STRUCTURE OF DNMT1-DNA COMPLEX REVEALS A ROLE FORTITL 2 AUTOINHIBITION IN MAINTENANCE DNA METHYLATION.REF SCIENCE V. 331 1036 2011REFN ISSN 0036-8075PMID 21163962DOI 10.1126/SCIENCE.1195380 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ipy DCK x-ray structure of human deoxycytidine kinase in complex with an inhibitor 2.54Å AUTH T.C.JESSOP,J.E.TARVER,M.CARLSEN,A.XU,J.P.HEALY,AUTH 2 A.HEIM-RIETHER,Q.FU,J.A.TAYLOR,D.J.AUGERI,M.SHEN,T.R.STOUCH,AUTH 3 R.V.SWANSON,L.W.TARI,M.HUNTER,I.HOFFMAN,P.E.KEYES,X.C.YU,AUTH 4 M.MIRANDA,Q.LIU,J.C.SWAFFIELD,S.DAVID KIMBALL,A.NOURALDEEN,AUTH 5 A.G.WILSON,A.M.FOUSHEE,K.JHAVER,R.FINCH,S.ANDERSON,AUTH 6 T.ORAVECZ,K.G.CARSONTITL LEAD OPTIMIZATION AND STRUCTURE-BASED DESIGN OF POTENT ANDTITL 2 BIOAVAILABLE DEOXYCYTIDINE KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 19 6784 2009REFN ISSN 0960-894XPMID 19836232DOI 10.1016/J.BMCL.2009.09.081 Variant Set Distributions […]