General Structure Information
| PDB ID | 2qnj |
| HGNC Gene Label(s) | MARK3 |
| Structure Name | kinase and ubiquitin-associated domains of mark3/par-1 |
| Resolution | 2.7Å |
| Reference | AUTH J.M.MURPHY,D.M.KORZHNEV,D.F.CECCARELLI,D.J.BRIANT,AUTH 2 A.ZARRINE-AFSAR,F.SICHERI,L.E.KAY,T.PAWSONTITL CONFORMATIONAL INSTABILITY OF THE MARK3 UBA DOMAINTITL 2 COMPROMISES UBIQUITIN RECOGNITION AND PROMOTES INTERACTIONTITL 3 WITH THE ADJACENT KINASE DOMAINREF PROC.NATL.ACAD.SCI.USA V. 104 14336 2007REFN ISSN 0027-8424PMID 17726107DOI 10.1073/PNAS.0703012104 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 313 |
| Number Of SNVs | 40 |
| Number Of Permutations | 18649 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.092 |
| p-value | 0.02 |
COSMIC
| Number Of Residues | 313 |
| Number Of SNVs | 3 |
| Number Of Permutations | 158 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 0.942 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 40 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.218 |
| p-value | 0.973 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
