Assessment of Structural Intolerance and Durability
General Structure Information 2oj4 RGS3 crystal structure of rgs3 rgs domain 2.3Å AUTH L.REZABKOVA,E.BOURA,P.HERMAN,J.VECER,L.BOUROVA,M.SULC,AUTH 2 P.SVOBODA,V.OBSILOVA,T.OBSILTITL 14-3-3 PROTEIN INTERACTS WITH AND AFFECTS THE STRUCTURE OFTITL 2 RGS DOMAIN OF REGULATOR OF G PROTEIN SIGNALING 3 (RGS3).REF J.STRUCT.BIOL. V. 170 451 2010REFN ISSN 1047-8477PMID 20347994DOI 10.1016/J.JSB.2010.03.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4jvm SULT1E1 crystal structure of human estrogen sulfotransferase (sult1e1) in complex with inactive cofactor pap and brominated flame retardant tbbpa (tetrabromobisphenol a) 1.99Å AUTH R.A.GOSAVI,G.A.KNUDSEN,L.S.BIRNBAUM,L.C.PEDERSENTITL MIMICKING OF ESTRADIOL BINDING BY FLAME RETARDANTS AND THEIRTITL 2 METABOLITES: A CRYSTALLOGRAPHIC ANALYSIS.REF ENVIRON.HEALTH PERSPECT. V. 121 1194 2013REFN ISSN 0091-6765PMID 23959441DOI 10.1289/EHP.1306902 Variant Set Distributions […]
General Structure Information 1wao PPP5C pp5 structure 2.9Å AUTH J.YANG,S.M.ROE,M.J.CLIFF,M.A.WILLIAMS,J.E.LADBURY,AUTH 2 P.T.COHEN,D.BARFORDTITL MOLECULAR BASIS FOR TPR DOMAIN-MEDIATED REGULATIONTITL 2 OF PROTEIN PHOSPHATASE 5REF EMBO J. V. 24 1 2005REFN ISSN 0261-4189PMID 15577939DOI 10.1038/SJ.EMBOJ.7600496 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2a72 RGS7 structure of the regulator of g-protein signaling domain of rgs7 2.0Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1z29 SULT1A2 crystal structures of sult1a2 and sult1a1*3: implications in the bioactivation of n-hydroxy-2-acetylamino fluorine (oh-aaf) 2.4Å AUTH J.LU,H.LI,J.ZHANG,M.LI,M.Y.LIU,X.AN,M.C.LIU,W.CHANGTITL CRYSTAL STRUCTURES OF SULT1A2 AND SULT1A1 *3: INSIGHTS INTOTITL 2 THE SUBSTRATE INHIBITION AND THE ROLE OF TYR149 IN SULT1A2.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 396 429 2010REFN ISSN 0006-291XPMID 20417180DOI 10.1016/J.BBRC.2010.04.109 Variant Set Distributions Ripley’s […]
General Structure Information 3sxs BMX crystal structure of bmx non-receptor tyrosine kinase complexed with pp2 1.89Å AUTH J.MUCKELBAUER,J.S.SACK,N.AHMED,J.BURKE,C.Y.CHANG,M.GAO,AUTH 2 J.TINO,D.XIE,A.J.TEBBENTITL X-RAY CRYSTAL STRUCTURE OF BONE MARROW KINASE IN THE XTITL 2 CHROMOSOME: A TEC FAMILY KINASE.REF CHEM.BIOL.DRUG DES. V. 78 739 2011REFN ISSN 1747-0277PMID 21883956DOI 10.1111/J.1747-0285.2011.01230.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4h3b MAPK10 crystal structure of jnk3 in complex with sab peptide 2.08Å AUTH J.D.LAUGHLIN,J.C.NWACHUKWU,M.FIGUERA-LOSADA,L.CHERRY,AUTH 2 K.W.NETTLES,P.V.LOGRASSOTITL STRUCTURAL MECHANISMS OF ALLOSTERY AND AUTOINHIBITION IN JNKTITL 2 FAMILY KINASES.REF STRUCTURE V. 20 2174 2012REFN ISSN 0969-2126PMID 23142346DOI 10.1016/J.STR.2012.09.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ayn USP14 structure of usp14, a proteasome-associated deubiquitinating enzyme 3.2Å AUTH M.HU,P.LI,L.SONG,P.D.JEFFREY,T.A.CHENOVA,AUTH 2 K.D.WILKINSON,R.E.COHEN,Y.SHITITL STRUCTURE AND MECHANISMS OF THETITL 2 PROTEASOME-ASSOCIATED DEUBIQUITINATING ENZYMETITL 3 USP14.REF EMBO J. V. 24 3747 2005REFN ISSN 0261-4189PMID 16211010DOI 10.1038/SJ.EMBOJ.7600832 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rm8 MMP16 crystal structure of the catalytic domain of mmp-16/mt3- mmp: characterization of mt-mmp specific features 1.8Å AUTH R.LANG,M.BRAUN,N.E.SOUNNI,A.NOEL,F.FRANKENNE,AUTH 2 J.M.FOIDART,W.BODE,K.MASKOSTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OFTITL 2 MMP-16/MT3-MMP: CHARACTERIZATION OF MT-MMPTITL 3 SPECIFIC FEATURES.REF J.MOL.BIOL. V. 336 213 2004REFN ISSN 0022-2836PMID 14741217DOI 10.1016/J.JMB.2003.12.022 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3qln ATRX crystal structure of atrx add domain in free state 1.9Å AUTH S.IWASE,B.XIANG,S.GHOSH,T.REN,P.W.LEWIS,J.C.COCHRANE,AUTH 2 C.D.ALLIS,D.J.PICKETTS,D.J.PATEL,H.LI,Y.SHITITL ATRX ADD DOMAIN LINKS AN ATYPICAL HISTONE METHYLATIONTITL 2 RECOGNITION MECHANISM TO HUMAN MENTAL-RETARDATION SYNDROMEREF NAT.STRUCT.MOL.BIOL. V. 18 769 2011REFN ISSN 1545-9993PMID 21666679DOI 10.1038/NSMB.2062 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]