Assessment of Structural Intolerance and Durability
General Structure Information 3zfy EPHB3 crystal structure of ephb3 2.2Å AUTH R.C.OVERMAN,J.E.DEBRECZENI,C.M.TRUMAN,M.S.MCALISTER,AUTH 2 T.K.ATTWOODTITL COMPLETING THE STRUCTURAL FAMILY PORTRAIT OF THE HUMAN EPHBTITL 2 TYROSINE KINASE DOMAINSREF PROTEIN SCI. V. 23 627 2014REFN ISSN 0961-8368PMID 24677421DOI 10.1002/PRO.2445 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 6jdw GATM crystal structure of human l-arginine:glycine amidinotransferase in complex with gamma-amino butyric acid 2.5Å AUTH E.FRITSCHE,A.HUMM,R.HUBERTITL THE LIGAND-INDUCED STRUCTURAL CHANGES OF HUMANTITL 2 L-ARGININE:GLYCINE AMIDINOTRANSFERASE. ATITL 3 MUTATIONAL AND CRYSTALLOGRAPHIC STUDY.REF J.BIOL.CHEM. V. 274 3026 1999REFN ISSN 0021-9258PMID 9915841DOI 10.1074/JBC.274.5.3026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2qkh GIPR crystal structure of the extracellular domain of human gip receptor in complex with the hormone gip 1.9Å AUTH C.PARTHIER,M.KLEINSCHMIDT,P.NEUMANN,R.RUDOLPH,AUTH 2 S.MANHART,D.SCHLENZIG,J.FANGHANEL,J.-U.RAHFELD,AUTH 3 H.-U.DEMUTH,M.T.STUBBSTITL CRYSTAL STRUCTURE OF THE INCRETIN-BOUNDTITL 2 EXTRACELLULAR DOMAIN OF A G PROTEIN-COUPLEDTITL 3 RECEPTORREF PROC.NATL.ACAD.SCI.USA V. 104 13942 2007REFN ISSN 0027-8424PMID 17715056DOI 10.1073/PNAS.0706404104 Variant Set Distributions Ripley’s […]
General Structure Information 4nie RORC crystal structure of the orphan nuclear receptor ror(gamma)t ligand- binding domain in complex with small molecule ligand 2.01Å AUTH T.YANG,L.QIAN,Y.B.CHENG,W.CAI,Y.L.MA,L.Q.YANG,Q.Q.WU,AUTH 2 L.A.ORBAND-MILLER,L.ZHOU,M.HUXDORF,W.ZHANG,J.ZHANG,AUTH 3 J.N.XIANG,S.LEUNG,Y.QIU,Z.ZHONG,J.D.ELLIOT,X.C.LIN,Y.H.WANGTITL DISCOVERY OF TERTIARY AMINE AND INDOLE DERIVATIVES AS POTENTTITL 2 ROR-GAMMA-T INVERSE AGONISTSREF ACS MED.CHEM.LETT. 2013REFN ISSN 1948-5875DOI 10.1021/ML4003875 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3hm8 HK3 crystal structure of the c-terminal hexokinase domain of human hk3 2.8Å AUTH L.NEDYALKOVA,Y.TONG,W.RABEH,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE C-TERMINAL HEXOKINASE DOMAIN OFTITL 2 HUMAN HK3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fd5 SEPHS1 crystal structure of human selenophosphate synthetase 1 complex with ampcp 1.9Å AUTH K.T.WANG,J.WANG,L.F.LI,X.D.SUTITL CRYSTAL STRUCTURES OF CATALYTIC INTERMEDIATES OFTITL 2 HUMAN SELENOPHOSPHATE SYNTHETASE 1.REF J.MOL.BIOL. V. 390 747 2009REFN ISSN 0022-2836PMID 19477186DOI 10.1016/J.JMB.2009.05.032 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2es0 RGS6 structure of the regulator of g-protein signaling domain of rgs6 2.1Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1h7u PMS2 hpms2-atpgs 2.7Å AUTH A.GUARNE,M.S.JUNOP,W.YANGTITL STRUCTURE AND FUNCTION OF THE N-TERMINAL 40 KDA FRAGMENT OFTITL 2 HUMAN PMS2: A MONOMERIC GHL ATPASEREF EMBO J. V. 20 5521 2001REFN ISSN 0261-4189PMID 11574484DOI 10.1093/EMBOJ/20.19.5521 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4jg7 RPS6KA3 structure of rsk2 ctd bound to 3-(3-(1h-pyrrolo[2,3-b]pyridine-3- carbonyl)phenyl)-2-cyanoacrylamide 3.0Å AUTH R.M.MILLER,V.O.PAAVILAINEN,S.KRISHNAN,I.M.SERAFIMOVA,AUTH 2 J.TAUNTONTITL ELECTROPHILIC FRAGMENT-BASED DESIGN OF REVERSIBLE COVALENTTITL 2 KINASE INHIBITORS.REF J.AM.CHEM.SOC. V. 135 5298 2013REFN ISSN 0002-7863PMID 23540679DOI 10.1021/JA401221B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1dt4 NOVA1 crystal structure of nova-1 kh3 k-homology rna-binding domain 2.6Å AUTH H.A.LEWIS,H.CHEN,C.EDO,R.J.BUCKANOVICH,Y.Y.YANG,AUTH 2 K.MUSUNURU,R.ZHONG,R.B.DARNELL,S.K.BURLEYTITL CRYSTAL STRUCTURES OF NOVA-1 AND NOVA-2 K-HOMOLOGYTITL 2 RNA-BINDING DOMAINS.REF STRUCTURE FOLD.DES. V. 7 191 1999REFN ISSN 0969-2126PMID 10368286DOI 10.1016/S0969-2126(99)80025-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants