General Structure Information
| PDB ID | 4nie |
| HGNC Gene Label(s) | RORC |
| Structure Name | crystal structure of the orphan nuclear receptor ror(gamma)t ligand- binding domain in complex with small molecule ligand |
| Resolution | 2.01Å |
| Reference | AUTH T.YANG,L.QIAN,Y.B.CHENG,W.CAI,Y.L.MA,L.Q.YANG,Q.Q.WU,AUTH 2 L.A.ORBAND-MILLER,L.ZHOU,M.HUXDORF,W.ZHANG,J.ZHANG,AUTH 3 J.N.XIANG,S.LEUNG,Y.QIU,Z.ZHONG,J.D.ELLIOT,X.C.LIN,Y.H.WANGTITL DISCOVERY OF TERTIARY AMINE AND INDOLE DERIVATIVES AS POTENTTITL 2 ROR-GAMMA-T INVERSE AGONISTSREF ACS MED.CHEM.LETT. 2013REFN ISSN 1948-5875DOI 10.1021/ML4003875 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 245 |
| Number Of SNVs | 47 |
| Number Of Permutations | 7733 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.29 |
| p-value | 0.01 |
COSMIC
| Number Of Residues | 245 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1114 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.2 |
| p-value | 0.269 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 47 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.327 |
| p-value | 0.058 |