General Structure Information
| PDB ID | 4jvm |
| HGNC Gene Label(s) | SULT1E1 |
| Structure Name | crystal structure of human estrogen sulfotransferase (sult1e1) in complex with inactive cofactor pap and brominated flame retardant tbbpa (tetrabromobisphenol a) |
| Resolution | 1.99Å |
| Reference | AUTH R.A.GOSAVI,G.A.KNUDSEN,L.S.BIRNBAUM,L.C.PEDERSENTITL MIMICKING OF ESTRADIOL BINDING BY FLAME RETARDANTS AND THEIRTITL 2 METABOLITES: A CRYSTALLOGRAPHIC ANALYSIS.REF ENVIRON.HEALTH PERSPECT. V. 121 1194 2013REFN ISSN 0091-6765PMID 23959441DOI 10.1289/EHP.1306902 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 292 |
| Number Of SNVs | 72 |
| Number Of Permutations | 8799 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.242 |
| p-value | 0.417 |
COSMIC
| Number Of Residues | 292 |
| Number Of SNVs | 6 |
| Number Of Permutations | 509 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.067 |
| p-value | 0.366 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 72 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.115 |
| p-value | 0.315 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
