Assessment of Structural Intolerance and Durability
General Structure Information 1vjb ESRRG crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4- hydroxytamoxifen 3.2Å AUTH H.GRESCHIK,R.FLAIG,J.P.RENAUD,D.MORASTITL STRUCTURAL BASIS FOR THE DEACTIVATION OF THETITL 2 ESTROGEN-RELATED RECEPTOR {GAMMA} BYTITL 3 DIETHYLSTILBESTROL OR 4-HYDROXYTAMOXIFEN ANDTITL 4 DETERMINANTS OF SELECTIVITY.REF J.BIOL.CHEM. V. 279 33639 2004REFN ISSN 0021-9258PMID 15161930DOI 10.1074/JBC.M402195200 Variant […]
General Structure Information 2wng SIRPA complete extracellular structure of human signal regulatory protein (sirp) alpha 2.49Å AUTH D.HATHERLEY,S.C.GRAHAM,K.HARLOS,D.I.STUART,AUTH 2 A.N.BARCLAYTITL STRUCTURE OF SIGNAL-REGULATORY PROTEIN ALPHA: ATITL 2 LINK TO ANTIGEN RECEPTOR EVOLUTION.REF J.BIOL.CHEM. V. 284 26613 2009REFN ISSN 0021-9258PMID 19628875DOI 10.1074/JBC.M109.017566 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1nkp MAX crystal structure of myc-max recognizing dna 1.8Å AUTH S.K.NAIR,S.K.BURLEYTITL X-RAY STRUCTURES OF MYC-MAX AND MAD-MAXTITL 2 RECOGNIZING DNA: MOLECULAR BASES OF REGULATION BYTITL 3 PROTO-ONCOGENIC TRANSCRIPTION FACTORSREF CELL(CAMBRIDGE,MASS.) V. 112 193 2003REFN ISSN 0092-8674PMID 12553908DOI 10.1016/S0092-8674(02)01284-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3w98 HIST1H3H crystal structure of human nucleosome core particle lacking h3.1 n- terminal region 3.42Å AUTH W.IWASAKI,Y.MIYA,N.HORIKOSHI,A.OSAKABE,H.TAGUCHI,AUTH 2 H.TACHIWANA,T.SHIBATA,W.KAGAWA,H.KURUMIZAKATITL CONTRIBUTION OF HISTONE N-TERMINAL TAILS TO THE STRUCTURETITL 2 AND STABILITY OF NUCLEOSOMESREF FEBS OPEN BIO V. 3 363 2013REFN ESSN 2211-5463PMID 24251097DOI 10.1016/J.FOB.2013.08.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3w98 HIST1H3J crystal structure of human nucleosome core particle lacking h3.1 n- terminal region 3.42Å AUTH W.IWASAKI,Y.MIYA,N.HORIKOSHI,A.OSAKABE,H.TAGUCHI,AUTH 2 H.TACHIWANA,T.SHIBATA,W.KAGAWA,H.KURUMIZAKATITL CONTRIBUTION OF HISTONE N-TERMINAL TAILS TO THE STRUCTURETITL 2 AND STABILITY OF NUCLEOSOMESREF FEBS OPEN BIO V. 3 363 2013REFN ESSN 2211-5463PMID 24251097DOI 10.1016/J.FOB.2013.08.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3w98 HIST1H3D crystal structure of human nucleosome core particle lacking h3.1 n- terminal region 3.42Å AUTH W.IWASAKI,Y.MIYA,N.HORIKOSHI,A.OSAKABE,H.TAGUCHI,AUTH 2 H.TACHIWANA,T.SHIBATA,W.KAGAWA,H.KURUMIZAKATITL CONTRIBUTION OF HISTONE N-TERMINAL TAILS TO THE STRUCTURETITL 2 AND STABILITY OF NUCLEOSOMESREF FEBS OPEN BIO V. 3 363 2013REFN ESSN 2211-5463PMID 24251097DOI 10.1016/J.FOB.2013.08.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3ex7 MAGOH the crystal structure of ejc in its transition state 2.3Å AUTH K.H.NIELSEN,H.CHAMIEH,C.B.ANDERSEN,F.FREDSLUND,AUTH 2 K.HAMBORG,H.LE HIR,G.R.ANDERSENTITL MECHANISM OF ATP TURNOVER INHIBITION IN THE EJCREF RNA V. 15 67 2009REFN ISSN 1355-8382PMID 19033377DOI 10.1261/RNA.1283109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zy7 ADARB1 crystal structure of the catalytic domain of an adenosine deaminase that acts on rna (hadar2) bound to inositol hexakisphosphate (ihp) 1.7Å AUTH M.R.MACBETH,H.L.SCHUBERT,A.P.VANDEMARK,A.T.LINGAM,AUTH 2 C.P.HILL,B.L.BASSTITL INOSITOL HEXAKISPHOSPHATE IS BOUND IN THE ADAR2TITL 2 CORE AND REQUIRED FOR RNA EDITING.REF SCIENCE V. 309 1534 2005REFN ISSN 0036-8075PMID 16141067DOI 10.1126/SCIENCE.1113150 Variant Set […]
General Structure Information 4md7 CSNK2B crystal structure of full-length symmetric ck2 holoenzyme 3.1Å AUTH G.LOLLI,A.RANCHIO,R.BATTISTUTTATITL ACTIVE FORM OF THE PROTEIN KINASE CK2 ALPHA 2 BETA 2TITL 2 HOLOENZYME IS A STRONG COMPLEX WITH SYMMETRIC ARCHITECTURE.REF ACS CHEM.BIOL. V. 9 366 2014REFN ISSN 1554-8929PMID 24175891DOI 10.1021/CB400771Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4guk NCS1 new crystal form structure of human ncs1 1.75Å AUTH F.CHENGPENG,L.ELIASTITL NEW CRYSTAL FORM STRUCTURE OF HUMAN NCS1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants