Assessment of Structural Intolerance and Durability
General Structure Information 2tgi TGFB2 crystal structure of transforming growth factor-beta2: an unusual fold for the superfamily 1.8Å AUTH S.DAOPIN,K.A.PIEZ,Y.OGAWA,D.R.DAVIESTITL CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA 2: ANTITL 2 UNUSUAL FOLD FOR THE SUPERFAMILY.REF SCIENCE V. 257 369 1992REFN ISSN 0036-8075PMID 1631557 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1gy5 NUTF2 d92n,d94n double point mutant of human nuclear transport factor 2 (ntf2) 2.3Å AUTH R.BAYLISS,S.LEUNG,R.BAKER,B.QUIMBY,A.CORBETT,AUTH 2 M.STEWARTTITL STRUCTURAL BASIS FOR THE INTERACTION BETWEEN NTF2TITL 2 AND NUCLEOPORIN FXFG REPEATSREF EMBO J. V. 21 2843 2002REFN ISSN 0261-4189PMID 12065398DOI 10.1093/EMBOJ/CDF305 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2lxp UBE2G2 nmr structure of two domains in ubiquitin ligase gp78, ring and g2br, bound to its conjugating enzyme ube2g -1.0Å AUTH R.DAS,Y.H.LIANG,J.MARIANO,J.LI,T.HUANG,A.KING,S.G.TARASOV,AUTH 2 A.M.WEISSMAN,X.JI,R.A.BYRDTITL ALLOSTERIC REGULATION OF E2:E3 INTERACTIONS PROMOTE ATITL 2 PROCESSIVE UBIQUITINATION MACHINE.REF EMBO J. V. 32 2504 2013REFN ISSN 0261-4189PMID 23942235DOI 10.1038/EMBOJ.2013.174 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1u7f SMAD3 crystal structure of the phosphorylated smad3/smad4 heterotrimeric complex 2.6Å AUTH B.M.CHACKO,B.Y.QIN,A.TIWARI,G.SHI,S.LAM,AUTH 2 L.J.HAYWARD,M.DE CAESTECKER,K.LINTITL STRUCTURAL BASIS OF HETEROMERIC SMAD PROTEINTITL 2 ASSEMBLY IN TGF-BETA SIGNALINGREF MOL.CELL V. 15 813 2004REFN ISSN 1097-2765PMID 15350224DOI 10.1016/J.MOLCEL.2004.07.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1foe RAC1 crystal structure of rac1 in complex with the guanine nucleotide exchange region of tiam1 2.8Å AUTH D.K.WORTHYLAKE,K.L.ROSSMAN,J.SONDEKTITL CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THETITL 2 GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1.REF NATURE V. 408 682 2000REFN ISSN 0028-0836PMID 11130063DOI 10.1038/35047014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2c47 CSNK1G2 structure of casein kinase 1 gamma 2 2.4Å AUTH G.BUNKOCZI,P.RELLOS,S.DAS,E.UGOCHUKWU,O.FEDOROV,F.SOBOTT,AUTH 2 J.ESWARAN,A.AMOS,L.BALL,F.VON DELFT,A.BULLOCK,J.DEBRECZENI,AUTH 3 A.TURNBULL,M.SUNDSTROM,J.WEIGELT,C.ARROWSMITH,A.EDWARDS,AUTH 4 S.KNAPPTITL THE STRUCTURE OF CASEIN KINASE 1 GAMMA 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xns GNAI1 crystal structure of human g alpha i1 bound to a designed helical peptide derived from the goloco motif of rgs14 3.41Å AUTH D.W.SAMMOND,D.E.BOSCH,G.L.BUTTERFOSS,C.PURBECK,AUTH 2 M.MACHIUS,D.P.SIDEROVSKI,B.KUHLMANTITL COMPUTATIONAL DESIGN OF THE SEQUENCE AND STRUCTURETITL 2 OF A PROTEIN-BINDING PEPTIDE.REF J.AM.CHEM.SOC. V. 133 4190 2011REFN ISSN 0002-7863PMID 21388199DOI 10.1021/JA110296Z Variant Set Distributions Ripley’s […]
General Structure Information 1taz PDE1B catalytic domain of human phosphodiesterase 1b 1.77Å AUTH K.Y.J.ZHANG,G.L.CARD,Y.SUZUKI,D.R.ARTIS,D.FONG,S.GILLETTE,AUTH 2 D.HSIEH,J.NEIMAN,B.L.WEST,C.ZHANG,M.V.MILBURN,S.-H.KIM,AUTH 3 J.SCHLESSINGER,G.BOLLAGTITL A GLUTAMINE SWITCH MECHANISM FOR NUCLEOTIDE SELECTIVITY BYTITL 2 PHOSPHODIESTERASESREF MOL.CELL V. 15 279 2004REFN ISSN 1097-2765PMID 15260978DOI 10.1016/J.MOLCEL.2004.07.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xzg CLTC clathrin terminal domain complexed with pitstop 1 1.7Å AUTH L.VON KLEIST,W.STAHLSCHMIDT,H.BULUT,K.GROMOVA,D.PUCHKOV,AUTH 2 M.J.ROBERTSON,K.A.MACGREGOR,N.TOMLIN,A.PECHSTEIN,N.CHAU,AUTH 3 M.CHIRCOP,J.SAKOFF,J.P.VON KRIES,W.SAENGER,H.KRAUSSLICH,AUTH 4 O.SHUPLIAKOV,P.J.ROBINSON,A.MCCLUSKEY,V.HAUCKETITL ROLE OF THE CLATHRIN TERMINAL DOMAIN IN REGULATING COATEDTITL 2 PIT DYNAMICS REVEALED BY SMALL MOLECULE INHIBITION.REF CELL(CAMBRIDGE,MASS.) V. 146 471 2011REFN ISSN 0092-8674PMID 21816279DOI 10.1016/J.CELL.2011.06.025 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1bi8 CDK6 mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]