Assessment of Structural Intolerance and Durability
General Structure Information 2yus SMARCC1 solution structure of the sant domain of human swi/snf- related matrix-associated actin-dependent regulator of chromatin subfamily c member 1 -1.0Å AUTH N.TOCHIO,S.KOSHIBA,K.SATIO,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SANT DOMAIN OF HUMANTITL 2 SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENTTITL 3 REGULATOR OF CHROMATIN SUBFAMILY C MEMBER 1REF TO BE PUBLISHEDREFN Variant Set Distributions […]
General Structure Information 1rj7 EDA crystal structure of eda-a1 2.3Å AUTH S.G.HYMOWITZ,D.M.COMPAAN,M.YAN,H.J.WALLWEBER,V.M.DIXIT,AUTH 2 M.A.STAROVASNIK,A.M.DE VOSTITL THE CRYSTAL STRUCTURES OF EDA-A1 AND EDA-A2: SPLICE VARIANTSTITL 2 WITH DISTINCT RECEPTOR SPECIFICITY.REF STRUCTURE V. 11 1513 2003REFN ISSN 0969-2126PMID 14656435DOI 10.1016/J.STR.2003.11.009 Variant Set Distributions Mapped Variants
General Structure Information 3nbh RMI2 crystal structure of human rmi1c-rmi2 complex 2.0Å AUTH F.WANG,Y.YANG,T.R.SINGH,V.BUSYGINA,R.GUO,K.WAN,W.WANG,AUTH 2 P.SUNG,A.R.MEETEI,M.LEITITL CRYSTAL STRUCTURES OF RMI1 AND RMI2, TWO OB-FOLD REGULATORYTITL 2 SUBUNITS OF THE BLM COMPLEX.REF STRUCTURE V. 18 1159 2010REFN ISSN 0969-2126PMID 20826342DOI 10.1016/J.STR.2010.06.008 Variant Set Distributions Mapped Variants
General Structure Information 4ly1 HDAC2 structure of human hdac2 in complex with inhibitor 4-(acetylamino)-n- [2-amino-5-(thiophen-2-yl)phenyl]benzamide 1.57Å AUTH B.E.LAUFFER,R.MINTZER,R.FONG,S.MUKUND,C.TAM,I.ZILBERLEYB,AUTH 2 B.FLICKE,A.RITSCHER,G.FEDOROWICZ,R.VALLERO,D.F.ORTWINE,AUTH 3 J.GUNZNER,Z.MODRUSAN,L.NEUMANN,C.M.KOTH,P.J.LUPARDUS,AUTH 4 J.S.KAMINKER,C.E.HEISE,P.STEINERTITL HISTONE DEACETYLASE (HDAC) INHIBITOR KINETIC RATE CONSTANTSTITL 2 CORRELATE WITH CELLULAR HISTONE ACETYLATION BUT NOTTITL 3 TRANSCRIPTION AND CELL VIABILITY.REF J.BIOL.CHEM. V. 288 26926 2013REFN ISSN 0021-9258PMID 23897821DOI 10.1074/JBC.M113.490706 Variant Set […]
General Structure Information 2rex RND1 crystal structure of the effector domain of plxnb1 bound with rnd1 gtpase 2.3Å AUTH Y.TONG,W.TEMPEL,L.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUNDTITL 2 WITH RND1 GTPASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ddg OTUB1 crystal structure of human otub1/ubch5b~ub/ub 3.3Å AUTH Y.C.JUANG,M.C.LANDRY,M.SANCHES,V.VITTAL,C.C.LEUNG,AUTH 2 D.F.CECCARELLI,A.R.MATEO,J.N.PRUNEDA,D.Y.MAO,R.K.SZILARD,AUTH 3 S.ORLICKY,M.MUNRO,P.S.BRZOVIC,R.E.KLEVIT,F.SICHERI,AUTH 4 D.DUROCHERTITL OTUB1 CO-OPTS LYS48-LINKED UBIQUITIN RECOGNITION TO SUPPRESSTITL 2 E2 ENZYME FUNCTION.REF MOL.CELL V. 45 384 2012REFN ISSN 1097-2765PMID 22325355DOI 10.1016/J.MOLCEL.2012.01.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2egm TRIM41 solution structure of the zf-b_box domain from human tripartite motif protein 41 -1.0Å AUTH K.INOUE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-B_BOX DOMAIN FROMTITL 2 HUMAN TRIPARTITE MOTIF PROTEIN 41REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nn6 EXOSC8 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Mapped Variants
General Structure Information 2lxs CREBBP allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic core -1.0Å AUTH S.BRUSCHWEILER,R.KONRAT,M.TOLLINGERTITL ALLOSTERIC COMMUNICATION IN THE KIX DOMAIN PROCEEDS THROUGHTITL 2 DYNAMIC REPACKING OF THE HYDROPHOBIC CORE.REF ACS CHEM.BIOL. 2013REFN ESSN 1554-8937PMID 23651431DOI 10.1021/CB4002188 Variant Set Distributions Mapped Variants
General Structure Information 3gvp AHCYL2 human sahh-like domain of human adenosylhomocysteinase 3 2.25Å AUTH M.I.SIPONEN,M.WISNIEWSKA,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.MOCHE,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,J.SAGEMARK,P.SCHUTZ,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 H.SCHUELERTITL HUMAN S-ADENOSYL HOMOCYSTEINE HYDROLASE-LIKE 2TITL 2 PROTEIN CRYSTAL STRUCTUREREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]