Assessment of Structural Intolerance and Durability
General Structure Information 4l1u RTF1 crystal structure of human rtf1 plus3 domain in complex with spt5 ctr phosphopeptide 2.42Å AUTH A.D.WIER,M.K.MAYEKAR,A.HEROUX,K.M.ARNDT,A.P.VANDEMARKTITL STRUCTURAL BASIS FOR SPT5-MEDIATED RECRUITMENT OF THE PAF1TITL 2 COMPLEX TO CHROMATIN.REF PROC.NATL.ACAD.SCI.USA V. 110 17290 2013REFN ISSN 0027-8424PMID 24101474DOI 10.1073/PNAS.1314754110 Variant Set Distributions Mapped Variants
General Structure Information 3f7g BIRC7 structure of the bir domain from ml-iap bound to a peptidomimetic 2.3Å AUTH F.COHEN,B.ALICKE,L.O.ELLIOTT,J.A.FLYGARE,T.GONCHAROV,AUTH 2 S.F.KETELTAS,M.C.FRANKLIN,S.FRANKOVITZ,J.P.STEPHAN,V.TSUI,AUTH 3 D.VUCIC,H.WONG,W.J.FAIRBROTHERTITL ORALLY BIOAVAILABLE ANTAGONISTS OF INHIBITOR OF APOPTOSISTITL 2 PROTEINS BASED ON AN AZABICYCLOOCTANE SCAFFOLDREF J.MED.CHEM. V. 52 1723 2009REFN ISSN 0022-2623PMID 19228017DOI 10.1021/JM801450C Variant Set Distributions Mapped Variants
General Structure Information 2ovq FBXW7 structure of the skp1-fbw7-cyclinedegc complex 2.6Å AUTH B.HAO,S.OEHLMANN,M.E.SOWA,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF A FBW7-SKP1-CYCLIN E COMPLEX:TITL 2 MULTISITE-PHOSPHORYLATED SUBSTRATE RECOGNITION BY SCFTITL 3 UBIQUITIN LIGASESREF MOL.CELL V. 26 131 2007REFN ISSN 1097-2765PMID 17434132DOI 10.1016/J.MOLCEL.2007.02.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1h6e AP2M1 mu2 adaptin subunit (ap50) of ap2 adaptor (second domain), complexed with ctla-4 internalization peptide ttgvyvkmppt 3.6Å AUTH E.R.FOLLOWS,J.C.MCPHEAT,C.MINSHULL,N.C.MOORE,AUTH 2 R.A.PAUPTIT,S.ROWSELL,C.L.STACEY,J.J.STANWAY,AUTH 3 I.W.TAYLOR,W.M.ABBOTTTITL STUDY OF THE INTERACTION OF THE MEDIUM CHAIN MU2TITL 2 SUBUNIT OF THE CLATHRIN-ASSOCIATED ADAPTER PROTEINTITL 3 COMPLEX 2 WITH CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4TITL 4 AND CD28REF BIOCHEM.J. […]
General Structure Information 3ff7 KLRG1 structure of nk cell receptor klrg1 bound to e-cadherin 1.8Å AUTH Y.LI,M.HOFMANN,Q.WANG,L.TENG,L.K.CHLEWICKI,AUTH 2 H.PIRCHER,R.A.MARIUZZATITL STRUCTURE OF NATURAL KILLER CELL RECEPTOR KLRG1TITL 2 BOUND TO E-CADHERIN REVEALS BASIS FORTITL 3 MHC-INDEPENDENT MISSING SELF RECOGNITION.REF IMMUNITY V. 31 35 2009REFN ISSN 1074-7613PMID 19604491DOI 10.1016/J.IMMUNI.2009.04.019 Variant Set Distributions Mapped Variants
General Structure Information 2yho MYLIP the idol-ube2d complex mediates sterol-dependent degradation of the ldl receptor 2.1Å AUTH L.ZHANG,L.FAIRALL,B.T.GOULT,A.C.CALKIN,C.HONG,C.J.MILLARD,AUTH 2 P.TONTONOZ,J.W.SCHWABETITL THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENTTITL 2 DEGRADATION OF THE LDL RECEPTOR.REF GENES DEV. V. 25 1262 2011REFN ISSN 0890-9369PMID 21685362DOI 10.1101/GAD.2056211 Variant Set Distributions Mapped Variants
General Structure Information 4hsa IL17RA structure of interleukin 17a in complex with il17ra receptor 3.15Å AUTH S.LIU,X.SONG,B.A.CHRUNYK,S.SHANKER,L.R.HOTH,E.S.MARR,AUTH 2 M.C.GRIFFORTITL CRYSTAL STRUCTURES OF INTERLEUKIN 17A AND ITS COMPLEX WITHTITL 2 IL-17 RECEPTOR A.REF NAT COMMUN V. 4 1888 2013REFN ESSN 2041-1723PMID 23695682DOI 10.1038/NCOMMS2880 Variant Set Distributions Mapped Variants
General Structure Information 3rjw EHMT2 crystal structure of histone lysine methyltransferase g9a with an inhibitor 2.56Å AUTH M.VEDADI,D.BARSYTE-LOVEJOY,F.LIU,S.RIVAL-GERVIER,AUTH 2 A.ALLALI-HASSANI,V.LABRIE,T.J.WIGLE,P.A.DIMAGGIO,G.A.WASNEY,AUTH 3 A.SIARHEYEVA,A.DONG,W.TEMPEL,S.C.WANG,X.CHEN,I.CHAU,AUTH 4 T.J.MANGANO,X.P.HUANG,C.D.SIMPSON,S.G.PATTENDEN,J.L.NORRIS,AUTH 5 D.B.KIREEV,A.TRIPATHY,A.EDWARDS,B.L.ROTH,W.P.JANZEN,AUTH 6 B.A.GARCIA,A.PETRONIS,J.ELLIS,P.J.BROWN,S.V.FRYE,AUTH 7 C.H.ARROWSMITH,J.JINTITL A CHEMICAL PROBE SELECTIVELY INHIBITS G9A AND GLPTITL 2 METHYLTRANSFERASE ACTIVITY IN CELLS.REF NAT.CHEM.BIOL. V. 7 566 2011REFN ISSN 1552-4450PMID 21743462DOI 10.1038/NCHEMBIO.599 Variant Set Distributions […]
General Structure Information 3siu PRPF31 structure of a hprp31-15.5k-u4atac 5 stem loop complex, monomeric form 2.63Å AUTH S.LIU,H.GHALEI,R.LUHRMANN,M.C.WAHLTITL STRUCTURAL BASIS FOR THE DUAL U4 AND U4ATAC SNRNA-BINDINGTITL 2 SPECIFICITY OF SPLICEOSOMAL PROTEIN HPRP31.REF RNA V. 17 1655 2011REFN ISSN 1355-8382PMID 21784869DOI 10.1261/RNA.2690611 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f8v TTN structure of full length telethonin in complex with the n-terminus of titin 2.75Å AUTH N.PINOTSIS,M.PETOUKHOV,S.LANGE,D.SVERGUN,P.ZOU,M.GAUTEL,AUTH 2 M.WILMANNSTITL EVIDENCE FOR A DIMERIC ASSEMBLY OF TWO TITIN/TELETHONINTITL 2 COMPLEXES INDUCED BY THE TELETHONIN C-TERMINUS.REF J.STRUCT.BIOL. V. 155 239 2006REFN ISSN 1047-8477PMID 16713295DOI 10.1016/J.JSB.2006.03.028 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]