4HSA.C | IL17RA

General Structure Information

PDB ID	4hsa
HGNC Gene Label(s)	IL17RA
Structure Name	structure of interleukin 17a in complex with il17ra receptor
Resolution	3.15Å
Reference	AUTH S.LIU,X.SONG,B.A.CHRUNYK,S.SHANKER,L.R.HOTH,E.S.MARR,AUTH 2 M.C.GRIFFORTITL CRYSTAL STRUCTURES OF INTERLEUKIN 17A AND ITS COMPLEX WITHTITL 2 IL-17 RECEPTOR A.REF NAT COMMUN V. 4 1888 2013REFN ESSN 2041-1723PMID 23695682DOI 10.1038/NCOMMS2880

Variant Set Distributions

ExAC Variants

Number Of Residues	272
Number Of SNVs	88
Number Of Permutations	22062
Optimal Distance Threshold	7.0
K Statistic	0.031
p-value	0.339

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
22:17577955		L>I	C:17	(-23.47, 62.73, -13.81)
22:17577962		C>Y	C:19	(-27.32, 58.72, -12.66)
22:17577965	rs143008696	T>M	C:20	(-30.13, 56.26, -11.23)
22:17577973		N>Y	C:23	(-38.41, 51.60, -14.44)
22:17577974		N>S	C:23	(-38.41, 51.60, -14.44)
22:17577976		S>G	C:24	(-40.87, 54.53, -17.10)
22:17578689		T>A	C:25	(-44.71, 55.06, -17.12)
22:17578720	rs201500195	R>Q	C:35	(-41.63, 71.27, -13.86)
22:17578732		P>L	C:39	(-35.02, 71.37, -20.61)
22:17578743		K>E	C:43	(-26.87, 67.56, -30.01)
22:17578746	rs143198423	D>N	C:44	(-26.16, 64.72, -32.46)
22:17578748		D>E	C:44	(-26.16, 64.72, -32.46)
22:17578750		L>P	C:45	(-30.32, 60.67, -31.82)
22:17578756		I>T	C:47	(-30.03, 54.55, -33.27)
22:17578757	rs374444452	I>M	C:47	(-30.03, 54.55, -33.27)
22:17578762		L>P	C:49	(-27.41, 46.88, -34.91)
22:17578768		F>C	C:51	(-25.33, 42.25, -32.41)
22:17578770	rs201996921	A>T	C:52	(-25.74, 40.91, -26.98)
22:17578774		H>R	C:53	(-24.01, 37.70, -25.53)
22:17578782		Q>K	C:56	(-28.41, 33.57, -19.56)
22:17578783		Q>R	C:56	(-28.41, 33.57, -19.56)
22:17578784		Q>H	C:56	(-28.41, 33.57, -19.56)
22:17578788	rs138012070	D>N	C:58	(-28.96, 33.70, -25.09)
22:17578800	rs147495146	V>M	C:62	(-29.19, 45.60, -29.08)
22:17578804		A>V	C:63	(-30.40, 49.16, -29.45)
22:17578812		E>K	C:66	(-25.14, 57.39, -29.48)
22:17579670		I>V	C:75	(-27.53, 72.00, -18.46)
22:17579682	rs376575302	E>K	C:79	(-34.63, 67.28, -13.77)
22:17579688		A>T	C:81	(-33.96, 61.21, -19.68)
22:17579696		L>F	C:83	(-34.66, 56.39, -22.91)
22:17579700		V>I	C:85	(-38.71, 51.84, -27.87)
22:17579709		L>M	C:88	(-44.13, 51.14, -35.88)
22:17579724		R>C	C:93	(-45.26, 52.97, -26.24)
22:17579725	rs367569746	R>H	C:93	(-45.26, 52.97, -26.24)
22:17579733	COSM3785598	V>I	C:96	(-35.84, 53.70, -19.44)
22:17579736		R>W	C:97	(-36.62, 57.75, -15.30)
22:17579740	rs372834294	F>Y	C:98	(-31.07, 57.99, -18.00)
22:17579766		H>Y	C:107	(-21.63, 72.75, -21.31)
22:17579776		R>Q	C:110	(-20.10, 68.67, -26.01)
22:17581245		W>R	C:111	(-21.76, 66.42, -19.98)
22:17581249		R>H	C:112	(-20.53, 63.06, -25.56)
22:17581260		S>C	C:116	(-27.22, 49.36, -24.94)
22:17581286	rs142199303	Q>H	C:124	(-39.37, 44.75, -36.66)
22:17581294	rs373988755	E>G	C:127	(-40.20, 56.07, -32.98)
22:17581302	rs552176381	V>I	C:130	(-34.28, 61.01, -26.31)
22:17581303	rs376923038	V>A	C:130	(-34.28, 61.01, -26.31)
22:17581351	rs374263008	S>F	C:146	(-37.04, 61.11, -32.73)
22:17582888		C>R	C:154	(-32.45, 36.53, -40.56)
22:17582897	rs527593084	A>T	C:157	(-24.57, 38.14, -41.38)
22:17582905		M>I	C:159	(-29.31, 39.10, -37.36)
22:17582913		T>S	C:162	(-29.42, 35.91, -33.35)
22:17582916	rs151220068	T>M	C:163	(-31.41, 33.69, -30.28)
22:17582924	rs552451486	M>V	C:166	(-30.70, 30.51, -34.37)
22:17583033	rs369409494	S>R	C:170	(-31.41, 30.71, -39.54)
22:17583047		N>S	C:175	(-30.16, 18.61, -48.49)
22:17583049		I>V	C:176	(-34.37, 20.11, -50.57)
22:17583055	rs534512644	V>M	C:178	(-36.38, 16.23, -56.01)
22:17583071	rs558799480	A>V	C:183	(-44.89, 5.72, -62.53)
22:17583074	rs200302492	H>P	C:184	(-47.09, 9.82, -63.39)
22:17583082		R>C	C:187	(-38.98, 9.62, -52.37)
22:17583083	rs140367455	R>H	C:187	(-38.98, 9.62, -52.37)
22:17583085	rs186541010	V>L	C:188	(-39.66, 14.67, -51.44)
22:17583109	rs371494126	S>A	C:196	(-41.73, 19.54, -31.54)
22:17583122		Q>R	C:200	(-47.20, 21.63, -44.51)
22:17583136	rs374891419	S>C	C:205	(-47.81, 21.06, -61.18)
22:17583139		F>L	C:206	(-46.72, 24.72, -62.71)
22:17583143		P>L	C:207	(-47.13, 23.99, -67.63)
22:17583145	rs369259606	H>Y	C:208	(-42.11, 24.33, -70.63)
22:17583151	rs140868574	E>K	C:210	(-47.72, 28.30, -69.01)
22:17583175	rs372584256	M>V	C:218	(-51.10, 19.69, -48.42)
22:17583178	rs556317837	H>D	C:219	(-47.71, 15.55, -47.10)
22:17583181		H>Y	C:220	(-49.06, 16.68, -42.06)
22:17583188		P>L	C:222	(-46.34, 14.79, -38.24)
22:17583191		A>V	C:223	(-44.47, 16.38, -34.92)
22:17584384	rs375341860	P>S	C:224	(-40.94, 15.72, -34.66)
22:17584390	rs199569526	P>A	C:226	(-36.79, 14.23, -29.57)
22:17584409		R>Q	C:232	(-33.19, 13.09, -44.73)
22:17584415	rs201250724	N>S	C:234	(-37.81, 10.36, -47.17)
22:17584417	rs112267700	V>I	C:235	(-42.47, 11.59, -48.81)
22:17584426		T>A	C:238	(-48.70, 10.38, -56.77)
22:17584430		L>P	C:239	(-47.63, 13.21, -59.92)
22:17584433		R>H	C:240	(-53.25, 15.55, -62.94)
22:17584454	rs141467790	R>H	C:247	(-43.30, 23.97, -64.15)
22:17585618		I>M	C:252	(-40.53, 22.45, -47.20)
22:17585620		Q>R	C:253	(-44.73, 25.46, -44.21)
22:17585622		P>S	C:254	(-41.74, 25.45, -41.38)
22:17585626		F>Y	C:255	(-45.80, 25.19, -39.13)
22:17585628		F>L	C:256	(-40.07, 26.27, -36.72)
22:17585635		S>I	C:258	(-40.77, 31.35, -33.49)
22:17585644	rs369019806	N>S	C:261	(-48.18, 30.72, -40.36)
22:17585656		R>K	C:265	(-43.03, 28.66, -47.17)
22:17585658	rs180787596	H>Y	C:266	(-36.97, 26.14, -47.62)
22:17585664	COSM3424021	A>T	C:268	(-37.86, 22.97, -55.28)
22:17585665		A>V	C:268	(-37.86, 22.97, -55.28)
22:17585670	rs149220878	V>I	C:270	(-38.61, 19.38, -61.25)
22:17585673		S>P	C:271	(-37.53, 20.09, -64.96)
22:17585679		P>S	C:273	(-37.18, 17.83, -71.45)