Assessment of Structural Intolerance and Durability
General Structure Information 3lbx SPTB crystal structure of the erythrocyte spectrin tetramerization domain complex 2.8Å AUTH J.J.IPSARO,S.L.HARPER,T.E.MESSICK,R.MARMORSTEIN,A.MONDRAGON,AUTH 2 D.W.SPEICHERTITL CRYSTAL STRUCTURE AND FUNCTIONAL INTERPRETATION OF THETITL 2 ERYTHROCYTE SPECTRIN TETRAMERIZATION DOMAIN COMPLEX.REF BLOOD V. 115 4843 2010REFN ISSN 0006-4971PMID 20197550DOI 10.1182/BLOOD-2010-01-261396 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1gxd MMP2 prommp-2/timp-2 complex 3.1Å AUTH E.MORGUNOVA,A.TUUTTILA,U.BERGMANN,K.TRYGGVASONTITL STRUCTURAL INSIGHT INTO THE COMPLEX FORMATION OF LATENTTITL 2 MATRIX METALLOPROTEINASE 2 WITH TISSUE INHIBITOR OFTITL 3 METALLOPROTEINASE 2REF PROC.NATL.ACAD.SCI.USA V. 99 7414 2002REFN ISSN 0027-8424PMID 12032297DOI 10.1073/PNAS.102185399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3eq1 HMBS the crystal structure of human porphobilinogen deaminase at 2.8a resolution 2.8Å AUTH R.GILL,S.E.KOLSTOE,F.MOHAMMED,A.AL D-BASS,AUTH 2 J.E.MOSELY,M.SARWAR,J.B.COOPER,S.P.WOOD,AUTH 3 P.M.SHOOLINGIN-JORDANTITL STRUCTURE OF HUMAN PORPHOBILINOGEN DEAMINASE AT 2.8TITL 2 A: THE MOLECULAR BASIS OF ACUTE INTERMITTENTTITL 3 PORPHYRIAREF BIOCHEM.J. V. 420 17 2009REFN ISSN 0264-6021PMID 19207107DOI 10.1042/BJ20082077 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2gjx HEXB crystallographic structure of human beta-hexosaminidase a 2.8Å AUTH M.J.LEMIEUX,B.L.MARK,M.M.CHERNEY,S.G.WITHERS,D.J.MAHURAN,AUTH 2 M.N.G.JAMESTITL CRYSTALLOGRAPHIC STRUCTURE OF HUMAN BETA-HEXOSAMINIDASE A:TITL 2 INTERPRETATION OF TAY-SACHS MUTATIONS AND LOSS OF GM2TITL 3 GANGLIOSIDE HYDROLYSISREF J.MOL.BIOL. V. 359 913 2006REFN ISSN 0022-2836PMID 16698036DOI 10.1016/J.JMB.2006.04.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2gk1 HEXA x-ray crystal structure of ngt-bound hexa 3.25Å AUTH M.J.LEMIEUX,B.L.MARK,M.M.CHERNEY,S.G.WITHERS,D.J.MAHURAN,AUTH 2 M.N.JAMESTITL CRYSTALLOGRAPHIC STRUCTURE OF HUMAN BETA-HEXOSAMINIDASE A:TITL 2 INTERPRETATION OF TAY-SACHS MUTATIONS AND LOSS OF G(M2)TITL 3 GANGLIOSIDE HYDROLYSIS.REF J.MOL.BIOL. V. 359 913 2006REFN ISSN 0022-2836PMID 16698036DOI 10.1016/J.JMB.2006.04.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1nr1 GLUD1 crystal structure of the r463a mutant of human glutamate dehydrogenase 3.3Å AUTH S.BANERJEE,T.SCHMIDT,J.FANG,C.A.STANLEY,T.J.SMITHTITL STRUCTURAL STUDIES ON ADP ACTIVATION OF MAMMALIANTITL 2 GLUTAMATE DEHYDROGENASE AND THE EVOLUTION OFTITL 3 REGULATIONREF BIOCHEMISTRY V. 42 3446 2003REFN ISSN 0006-2960PMID 12653548DOI 10.1021/BI0206917 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1sos SOD1 atomic structures of wild-type and thermostable mutant recombinant human cu, zn superoxide dismutase 2.5Å AUTH H.E.PARGE,R.A.HALLEWELL,J.A.TAINERTITL ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLETITL 2 MUTANT RECOMBINANT HUMAN CU,ZN SUPEROXIDETITL 3 DISMUTASE.REF PROC.NATL.ACAD.SCI.USA V. 89 6109 1992REFN ISSN 0027-8424PMID 1463506DOI 10.1073/PNAS.89.13.6109 Variant Set Distributions Mapped Variants
General Structure Information 3ruk CYP17A1 human cytochrome p450 cyp17a1 in complex with abiraterone 2.6Å AUTH N.M.DEVORE,E.E.SCOTTTITL STRUCTURES OF CYTOCHROME P450 17A1 WITH PROSTATE CANCERTITL 2 DRUGS ABIRATERONE AND TOK-001.REF NATURE V. 482 116 2012REFN ISSN 0028-0836PMID 22266943DOI 10.1038/NATURE10743 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2wpl F9 factor ixa superactive triple mutant, edta-soaked 1.82Å AUTH T.ZOGG,H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE COFACTOR- ANDTITL 2 SUBSTRATE-ASSISTED ACTIVATION OF HUMAN COAGULATIONTITL 3 FACTOR IXAREF STRUCTURE V. 17 1669 2009REFN ISSN 0969-2126PMID 20004170DOI 10.1016/J.STR.2009.10.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1brp RBP4 crystal structure of the trigonal form of human plasma retinol-binding protein at 2.5 angstroms resolution 2.5Å AUTH G.ZANOTTI,S.OTTONELLO,R.BERNI,H.L.MONACOTITL CRYSTAL STRUCTURE OF THE TRIGONAL FORM OF HUMANTITL 2 PLASMA RETINOL-BINDING PROTEIN AT 2.5 A RESOLUTION.REF J.MOL.BIOL. V. 230 613 1993REFN ISSN 0022-2836PMID 8464067DOI 10.1006/JMBI.1993.1173 Variant Set Distributions Mapped Variants