2J0F.A | TYMP

General Structure Information 2j0f TYMP structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design 2.31Å AUTH K.EL OMARI,A.BRONCKAERS,S.LIEKENS,M.PEREZ-PEREZ,AUTH 2 J.BALZARINI,D.K.STAMMERSTITL STRUCTURAL BASIS FOR NON-COMPETITIVE PRODUCTTITL 2 INHIBITION IN HUMAN THYMIDINE PHOSPHORYLASE:TITL 3 IMPLICATIONS FOR DRUG DESIGN.REF BIOCHEM.J. V. 399 199 2006REFN ISSN 0264-6021PMID 16803458DOI 10.1042/BJ20060513 Variant Set Distributions Ripley’s K […]

See Details
3LCO.A | CSF1R

General Structure Information 3lco CSF1R inhibitor bound to a dfg-out structure of the kinase domain of csf-1r 3.4Å AUTH M.J.MEYERS,M.PELC,S.KAMTEKAR,J.DAY,G.I.PODA,M.K.HALL,AUTH 2 M.L.MICHENER,B.A.REITZ,K.J.MATHIS,B.S.PIERCE,M.D.PARIKH,AUTH 3 D.A.MISCHKE,S.A.LONG,J.J.PARLOW,D.R.ANDERSON,A.THORARENSENTITL STRUCTURE-BASED DRUG DESIGN ENABLES CONVERSION OF A DFG-INTITL 2 BINDING CSF-1R KINASE INHIBITOR TO A DFG-OUT BINDING MODE.REF BIOORG.MED.CHEM.LETT. V. 20 1543 2010REFN ISSN 0960-894XPMID 20137931DOI 10.1016/J.BMCL.2010.01.078 Variant Set Distributions Pathogenic […]

See Details
3LXC.A | GLA

General Structure Information 3lxc GLA interconversion of human lysosomal enzyme specificities 2.35Å AUTH I.B.TOMASIC,M.C.METCALF,A.I.GUCE,N.E.CLARK,S.C.GARMANTITL INTERCONVERSION OF THE SPECIFICITIES OF HUMAN LYSOSOMALTITL 2 ENZYMES ASSOCIATED WITH FABRY AND SCHINDLER DISEASES.REF J.BIOL.CHEM. V. 285 21560 2010REFN ISSN 0021-9258PMID 20444686DOI 10.1074/JBC.M110.118588 Variant Set Distributions Mapped Variants

See Details
4ELJ.A | RB1

General Structure Information 4elj RB1 crystal structure of the inactive retinoblastoma protein phosphorylated at t373 2.7Å AUTH J.R.BURKE,G.L.HURA,S.M.RUBINTITL STRUCTURES OF INACTIVE RETINOBLASTOMA PROTEIN REVEALTITL 2 MULTIPLE MECHANISMS FOR CELL CYCLE CONTROL.REF GENES DEV. V. 26 1156 2012REFN ISSN 0890-9369PMID 22569856DOI 10.1101/GAD.189837.112 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]

See Details
2FGI.A | FGFR1

General Structure Information 2fgi FGFR1 crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074 2.5Å AUTH M.MOHAMMADI,S.FROUM,J.M.HAMBY,M.C.SCHROEDER,AUTH 2 R.L.PANEK,G.H.LU,A.V.ELISEENKOVA,D.GREEN,AUTH 3 J.SCHLESSINGER,S.R.HUBBARDTITL CRYSTAL STRUCTURE OF AN ANGIOGENESIS INHIBITORTITL 2 BOUND TO THE FGF RECEPTOR TYROSINE KINASE DOMAIN.REF EMBO J. V. 17 5896 1998REFN ISSN 0261-4189PMID 9774334DOI 10.1093/EMBOJ/17.20.5896 Variant Set […]

See Details
1T2F.C | LDHB

General Structure Information 1t2f LDHB human b lactate dehydrogenase complexed with nad+ and 4- hydroxy-1,2,5-oxadiazole-3-carboxylic acid 3.0Å AUTH A.CAMERON,J.READ,R.TRANTER,V.J.WINTER,R.B.SESSIONS,AUTH 2 R.L.BRADY,L.VIVAS,A.EASTON,H.KENDRICK,S.L.CROFT,AUTH 3 D.BARROS,J.L.LAVANDERA,J.J.MARTIN,F.RISCO,AUTH 4 S.GARCIA-OCHOA,F.J.GAMO,L.SANZ,L.LEON,J.R.RUIZ,AUTH 5 R.GABARRO,A.MALLO,F.G.DE LAS HERASTITL IDENTIFICATION AND ACTIVITY OF A SERIES OFTITL 2 AZOLE-BASED COMPOUNDS WITH LACTATETITL 3 DEHYDROGENASE-DIRECTED ANTI-MALARIAL ACTIVITY.REF J.BIOL.CHEM. V. 279 31429 2004REFN ISSN 0021-9258PMID 15117937DOI 10.1074/JBC.M402433200 Variant […]

See Details
1P49.A | STS

General Structure Information 1p49 STS structure of human placental estrone/dhea sulfatase 2.6Å AUTH F.G.HERNANDEZ-GUZMAN,T.HIGASHIYAMA,W.PANGBORN,Y.OSAWA,AUTH 2 D.GHOSHTITL STRUCTURE OF HUMAN ESTRONE SULFATASE SUGGESTS FUNCTIONALTITL 2 ROLES OF MEMBRANE ASSOCIATIONREF J.BIOL.CHEM. V. 278 22989 2003REFN ISSN 0021-9258PMID 12657638DOI 10.1074/JBC.M211497200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants

See Details
1NQ0.A | THRB

General Structure Information 1nq0 THRB tr receptor mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the nterminal lbd 2.4Å AUTH B.R.HUBER,M.DESCLOZEAUX,B.L.WEST,S.T.CUNHA-LIMA,H.T.NGUYEN,AUTH 2 J.D.BAXTER,H.A.INGRAHAM,R.J.FLETTERICKTITL THYROID HORMONE RECEPTOR-BETA MUTATIONS CONFERRING HORMONETITL 2 RESISTANCE AND REDUCED COREPRESSOR RELEASE EXHIBIT DECREASEDTITL 3 STABILITY IN THE N-TERMINAL LIGAND-BINDING DOMAINREF MOL.ENDOCRINOL. V. 17 107 2003REFN ISSN 0888-8809PMID […]

See Details
1L5S.A | PYGL

General Structure Information 1l5s PYGL human liver glycogen phosphorylase complexed with uric acid, n-acetyl- beta-d-glucopyranosylamine, and cp-403,700 2.1Å AUTH J.L.EKSTROM,T.A.PAULY,M.D.CARTY,W.C.SOELLER,J.CULP,AUTH 2 D.E.DANLEY,D.J.HOOVER,J.L.TREADWAY,E.M.GIBBS,R.J.FLETTERICK,AUTH 3 Y.S.DAY,D.G.MYSZKA,V.L.RATHTITL STRUCTURE-ACTIVITY ANALYSIS OF THE PURINE BINDING SITE OFTITL 2 HUMAN LIVER GLYCOGEN PHOSPHORYLASE.REF CHEM.BIOL. V. 9 915 2002REFN ISSN 1074-5521PMID 12204691DOI 10.1016/S1074-5521(02)00186-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]

See Details
3BG3.A | PC

General Structure Information 3bg3 PC crystal structure of human pyruvate carboxylase (missing the biotin carboxylase domain at the n-terminus) 2.8Å AUTH S.XIANG,L.TONGTITL CRYSTAL STRUCTURES OF HUMAN AND STAPHYLOCOCCUSTITL 2 AUREUS PYRUVATE CARBOXYLASE AND MOLECULAR INSIGHTSTITL 3 INTO THE CARBOXYLTRANSFER REACTION.REF NAT.STRUCT.MOL.BIOL. V. 15 295 2008REFN ISSN 1545-9993PMID 18297087DOI 10.1038/NSMB.1393 Variant Set Distributions Ripley’s K Analysis […]

See Details