Assessment of Structural Intolerance and Durability
General Structure Information 1ux6 THBS1 structure of a thrombospondin c-terminal fragment reveals a novel calcium core in the type 3 repeats 1.9Å AUTH M.KVANSAKUL,J.C.ADAMS,E.HOHENESTERTITL STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENTTITL 2 REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATSREF EMBO J. V. 23 1223 2004REFN ISSN 0261-4189PMID 15014436DOI 10.1038/SJ.EMBOJ.7600166 Variant Set Distributions Ripley’s […]
General Structure Information 1lsl THBS1 crystal structure of the thrombospondin-1 type 1 repeats 1.9Å AUTH K.TAN,M.DUQUETTE,J.H.LIU,Y.DONG,R.ZHANG,AUTH 2 A.JOACHIMIAK,J.LAWLER,J.H.WANGTITL CRYSTAL STRUCTURE OF THE TSP-1 TYPE 1 REPEATS: ATITL 2 NOVEL LAYERED FOLD AND ITS BIOLOGICAL IMPLICATION.REF J.CELL BIOL. V. 159 373 2002REFN ISSN 0021-9525PMID 12391027DOI 10.1083/JCB.200206062 Variant Set Distributions Mapped Variants
General Structure Information 2v53 SPARC crystal structure of a sparc-collagen complex 3.2Å AUTH E.HOHENESTER,T.SASAKI,C.GIUDICI,R.W.FARNDALE,AUTH 2 H.P.BACHINGERTITL STRUCTURAL BASIS OF SEQUENCE-SPECIFIC COLLAGENTITL 2 RECOGNITION BY SPARC.REF PROC.NATL.ACAD.SCI.USA V. 105 18273 2008REFN ISSN 0027-8424PMID 19011090DOI 10.1073/PNAS.0808452105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fcs ITGA2B structure of complete ectodomain of integrin aiibb3 2.55Å AUTH J.ZHU,B.H.LUO,T.XIAO,C.ZHANG,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF A COMPLETE INTEGRIN ECTODOMAIN IN A PHYSIOLOGICTITL 2 RESTING STATE AND ACTIVATION AND DEACTIVATION BY APPLIEDTITL 3 FORCES.REF MOL.CELL V. 32 849 2008REFN ISSN 1097-2765PMID 19111664DOI 10.1016/J.MOLCEL.2008.11.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3bch RPSA crystal structure of the human laminin receptor precursor 2.15Å AUTH K.V.JAMIESON,J.WU,S.R.HUBBARD,D.MERUELOTITL CRYSTAL STRUCTURE OF THE HUMAN LAMININ RECEPTORTITL 2 PRECURSOR.REF J.BIOL.CHEM. V. 283 3002 2008REFN ISSN 0021-9258PMID 18063583DOI 10.1074/JBC.C700206200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2knc ITGA2B platelet integrin alfaiib-beta3 transmembrane-cytoplasmic heterocomplex -1.0Å AUTH J.YANG,Y.Q.MA,R.C.PAGE,S.MISRA,E.F.PLOW,J.QINTITL STRUCTURE OF AN INTEGRIN ALPHAIIB BETA3TITL 2 TRANSMEMBRANE-CYTOPLASMIC HETEROCOMPLEX PROVIDES INSIGHTTITL 3 INTO INTEGRIN ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 17729 2009REFN ISSN 0027-8424PMID 19805198DOI 10.1073/PNAS.0909589106 Variant Set Distributions Mapped Variants
General Structure Information 2ouj THBS1 the crystal structure of the thrombospondin-1 n-terminal domain in complex with fractionated heparin dp8 1.9Å AUTH K.TAN,M.DUQUETTE,J.H.LIU,K.SHANMUGASUNDARAM,AUTH 2 A.JOACHIMIAK,J.T.GALLAGHER,A.C.RIGBY,J.H.WANG,AUTH 3 J.LAWLERTITL HEPARIN-INDUCED CIS- AND TRANS-DIMERIZATION MODESTITL 2 OF THE THROMBOSPONDIN-1 N-TERMINAL DOMAIN.REF J.BIOL.CHEM. V. 283 3932 2008REFN ISSN 0021-9258PMID 18065761DOI 10.1074/JBC.M705203200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3m7p FN1 fibronectin fragment 2.5Å AUTH M.GRAILLE,M.PAGANO,T.ROSE,M.REBOUD RAVAUX,H.VAN TILBEURGHTITL ZINC INDUCES STRUCTURAL REORGANIZATION OF GELATIN BINDINGTITL 2 DOMAIN FROM HUMAN FIBRONECTIN AND AFFECTS COLLAGEN BINDINGREF STRUCTURE V. 18 710 2010REFN ISSN 0969-2126PMID 20541508DOI 10.1016/J.STR.2010.03.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ije ITGB3 crystal structure of the complete integrin alhavbeta3 ectodomain plus an alpha/beta transmembrane fragment 2.9Å AUTH J.P.XIONG,B.MAHALINGHAM,J.L.ALONSO,L.A.BORRELLI,X.RUI,AUTH 2 S.ANAND,B.T.HYMAN,T.RYSIOK,D.MULLER-POMPALLA,S.L.GOODMAN,AUTH 3 M.A.ARNAOUTTITL CRYSTAL STRUCTURE OF THE COMPLETE INTEGRIN ALPHAVBETA3TITL 2 ECTODOMAIN PLUS AN ALPHA/BETA TRANSMEMBRANE FRAGMENT.REF J.CELL BIOL. V. 186 589 2009REFN ISSN 0021-9525PMID 19704023DOI 10.1083/JCB.200905085 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2ha1 FN1 complex of the first and second type iii domains of human fibronectin in solution -1.0Å AUTH I.VAKONAKIS,D.STAUNTON,L.M.ROONEY,I.D.CAMPBELLTITL INTERDOMAIN ASSOCIATION IN FIBRONECTIN: INSIGHTTITL 2 INTO CRYPTIC SITES AND FIBRILLOGENESIS.REF EMBO J. V. 26 2575 2007REFN ISSN 0261-4189PMID 17464288DOI 10.1038/SJ.EMBOJ.7601694 Variant Set Distributions Mapped Variants