Assessment of Structural Intolerance and Durability
General Structure Information 3cfw SELL l-selectin lectin and egf domains 2.2Å AUTH P.MEHTA,R.P.MCEVERTITL STRUCTURE OF LECTIN AND EGF DOMAINS OF L-SELECTINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3f7p ITGB4 crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 3v4v ITGA4 crystal structure of a4b7 headpiece complexed with fab act-1 and ro0505376 3.1Å AUTH Y.YU,J.ZHU,L.Z.MI,T.WALZ,H.SUN,J.CHEN,T.A.SPRINGERTITL STRUCTURAL SPECIALIZATIONS OF A4B7, AN INTEGRIN THATTITL 2 MEDIATES ROLLING ADHESIONREF J.CELL BIOL. V. 196 131 2012REFN ISSN 0021-9525PMID 22232704DOI 10.1083/JCB.201110023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2o72 CDH1 crystal structure analysis of human e-cadherin (1-213) 2.0Å AUTH E.PARISINI,J.M.G.HIGGINS,J.-H.LIU,M.B.BRENNER,AUTH 2 J.-H.WANGTITL THE CRYSTAL STRUCTURE OF HUMAN E-CADHERIN DOMAINSTITL 2 1 AND 2, AND COMPARISON WITH OTHER CADHERINS INTITL 3 THE CONTEXT OF ADHESION MECHANISMREF J.MOL.BIOL. V. 373 401 2007REFN ISSN 0022-2836PMID 17850815DOI 10.1016/J.JMB.2007.08.011 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2gk2 CEACAM1 crystal structure of the n terminal domain of human ceacam1 2.2Å AUTH A.FEDAROVICH,J.TOMBERG,R.A.NICHOLAS,C.DAVIESTITL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN CEACAM1: BINDINGTITL 2 TARGET OF THE OPACITY PROTEINS DURING INVASION OF NEISSERIATITL 3 MENINGITIDIS AND N. GONORRHOEAE.REF ACTA CRYSTALLOGR.,SECT.D V. 62 971 2006REFN ISSN 0907-4449PMID 16929097DOI 10.1107/S0907444906020737 Variant Set Distributions […]
General Structure Information 3r6n DSP crystal structure of a rigid four spectrin repeat fragment of the human desmoplakin plakin domain 2.95Å AUTH H.J.CHOI,W.I.WEISTITL CRYSTAL STRUCTURE OF A RIGID FOUR-SPECTRIN-REPEAT FRAGMENTTITL 2 OF THE HUMAN DESMOPLAKIN PLAKIN DOMAIN.REF J.MOL.BIOL. V. 409 800 2011REFN ISSN 0022-2836PMID 21536047DOI 10.1016/J.JMB.2011.04.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1zxq ICAM2 the crystal structure of icam-2 2.2Å AUTH J.M.CASASNOVAS,T.A.SPRINGER,J.H.LIU,S.C.HARRISON,J.H.WANGTITL CRYSTAL STRUCTURE OF ICAM-2 REVEALS A DISTINCTIVE INTEGRINTITL 2 RECOGNITION SURFACE.REF NATURE V. 387 312 1997REFN ISSN 0028-0836PMID 9153399DOI 10.1038/387312A0 Variant Set Distributions Mapped Variants
General Structure Information 3mtr NCAM1 crystal structure of the ig5-fn1 tandem of human ncam 1.8Å AUTH D.A.FOLEY,K.G.SWARTZENTRUBER,A.LAVIE,K.J.COLLEYTITL STRUCTURE AND MUTAGENESIS OF NEURAL CELL ADHESION MOLECULETITL 2 DOMAINS: EVIDENCE FOR FLEXIBILITY IN THE PLACEMENT OFTITL 3 POLYSIALIC ACID ATTACHMENT SITESREF J.BIOL.CHEM. V. 285 27360 2010REFN ISSN 0021-9258PMID 20573953DOI 10.1074/JBC.M110.140038 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4bj3 ITGA2 integrin alpha2 i domain e318w-collagen complex 3.04Å AUTH F.CARAFOLI,S.W.HAMAIA,D.BIHAN,E.HOHENESTER,R.W.FARNDALETITL AN ACTIVATING MUTATION REVEALS A SECOND BINDING MODE OF THETITL 2 INTEGRIN ALPHA2 I DOMAIN TO THE GFOGER MOTIF IN COLLAGENS.REF PLOS ONE V. 8 69833 2013REFN ISSN 1932-6203PMID 23922814DOI 10.1371/JOURNAL.PONE.0069833 Variant Set Distributions Mapped Variants