Assessment of Structural Intolerance and Durability
General Structure Information 3k71 ITGB2 structure of integrin alphax beta2 ectodomain 3.95Å AUTH C.XIE,J.ZHU,X.CHEN,L.MI,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF AN INTEGRIN WITH AN ALPHAI DOMAIN,TITL 2 COMPLEMENT RECEPTOR TYPE 4.REF EMBO J. V. 29 666 2010REFN ISSN 0261-4189PMID 20033057DOI 10.1038/EMBOJ.2009.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4c29 VWF crystal structure of high-affinity von willebrand factor a1 domain with disulfide mutation 2.2Å AUTH M.A.BLENNER,X.DONG,T.A.SPRINGERTITL TOWARDS THE STRUCTURAL BASIS OF REGULATION OF VONTITL 2 WILLEBRAND FACTOR BINDING TO GLYCOPROTEIN IBREF J.BIOL.CHEM. V. 289 5565 2014REFN ISSN 0021-9258PMID 24391089DOI 10.1074/JBC.M113.511220 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3r8q FN1 structure of fibronectin domain 12-14 2.4Å AUTH N.R.ZACCAI,C.AGNEW,R.L.BRADYTITL STRUCTURE OF FIBRONECTIN DOMAIN 12-14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1o9a FN1 solution structure of the complex of 1f12f1 from fibronectin with b3 from fnbb from s. dysgalactiae -1.0Å AUTH U.SCHWARZ-LINEK,J.M.WERNER,A.R.PICKFORD,S.GURUSIDDAPPA,AUTH 2 J.H.KIM,E.S.PILKA,J.A.G.BRIGGS,T.S.GOUGH,M.HOOK,AUTH 3 I.D.CAMPBELL,J.R.POTTSTITL PATHOGENIC BACTERIA ATTACH TO HUMAN FIBRONECTIN THROUGH ATITL 2 TANDEM BETA-ZIPPER.REF NATURE V. 423 177 2003REFN ISSN 0028-0836PMID 12736686DOI 10.1038/NATURE01589 Variant Set Distributions Mapped Variants
General Structure Information 2knc ITGB3 platelet integrin alfaiib-beta3 transmembrane-cytoplasmic heterocomplex -1.0Å AUTH J.YANG,Y.Q.MA,R.C.PAGE,S.MISRA,E.F.PLOW,J.QINTITL STRUCTURE OF AN INTEGRIN ALPHAIIB BETA3TITL 2 TRANSMEMBRANE-CYTOPLASMIC HETEROCOMPLEX PROVIDES INSIGHTTITL 3 INTO INTEGRIN ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 17729 2009REFN ISSN 0027-8424PMID 19805198DOI 10.1073/PNAS.0909589106 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3bt1 PLAU structure of urokinase receptor, urokinase and vitronectin complex 2.8Å AUTH Q.HUAI,A.ZHOU,L.LIN,A.P.MAZAR,G.C.PARRY,J.CALLAHAN,D.E.SHAW,AUTH 2 B.FURIE,B.C.FURIE,M.HUANGTITL CRYSTAL STRUCTURES OF TWO HUMAN VITRONECTIN, UROKINASE ANDTITL 2 UROKINASE RECEPTOR COMPLEXESREF NAT.STRUCT.MOL.BIOL. V. 15 422 2008REFN ISSN 1545-9993PMID 18376415DOI 10.1038/NSMB.1404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yst PCDH7 solution structure of the third cadherin domain from human protocadherin 7 -1.0Å AUTH K.SEIMIYA,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD CADHERIN DOMAINTITL 2 FROM HUMAN PROTOCADHERIN 7REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ebp SASH1 solution structure of the sh3 domain from human sam and sh3 domain containing protein 1 -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN FROM HUMANTITL 2 SAM AND SH3 DOMAIN CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4d90 EDIL3 crystal structure of del-1 egf domains 2.6Å AUTH T.SCHURPF,Q.CHEN,J.H.LIU,R.WANG,T.A.SPRINGER,J.H.WANGTITL THE RGD FINGER OF DEL-1 IS A UNIQUE STRUCTURAL FEATURETITL 2 CRITICAL FOR INTEGRIN BINDING.REF FASEB J. V. 26 3412 2012REFN ISSN 0892-6638PMID 22601780DOI 10.1096/FJ.11-202036 Variant Set Distributions Mapped Variants
General Structure Information 4n68 CNTN5 crystal structure of an internal fn3 domain from human contactin-5 [psi-nysgrc-005804] 1.8Å AUTH P.R.KUMAR,A.CASADEVALL,S.C.ALMOTITL CRYSTAL STRUCTURE OF AN INTERNAL FN3 DOMAIN FROM HUMANTITL 2 CONTACTIN-5 [PSI-NYSGRC-005804]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants