Assessment of Structural Intolerance and Durability
General Structure Information 3f6k SORT1 crystal structure of the vps10p domain of human sortilin/nts3 in complex with neurotensin 2.0Å AUTH E.M.QUISTGAARD,P.MADSEN,M.K.GROFTEHAUGE,P.NISSEN,AUTH 2 C.M.PETERSEN,S.S.THIRUPTITL LIGANDS BIND TO SORTILIN IN THE TUNNEL OF A TEN-BLADEDTITL 2 BETA-PROPELLER DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 16 96 2009REFN ISSN 1545-9993PMID 19122660DOI 10.1038/NSMB.1543 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4gqb WDR77 crystal structure of the human prmt5:mep50 complex 2.06Å AUTH S.ANTONYSAMY,Z.BONDAY,R.M.CAMPBELL,B.DOYLE,Z.DRUZINA,AUTH 2 T.GHEYI,B.HAN,L.N.JUNGHEIM,Y.QIAN,C.RAUCH,M.RUSSELL,AUTH 3 J.M.SAUDER,S.R.WASSERMAN,K.WEICHERT,F.S.WILLARD,A.ZHANG,AUTH 4 S.EMTAGETITL CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 17960 2012REFN ISSN 0027-8424PMID 23071334DOI 10.1073/PNAS.1209814109 Variant Set Distributions Mapped Variants
General Structure Information 1olz SEMA4D the ligand-binding face of the semaphorins revealed by the high resolution crystal structure of sema4d 2.0Å AUTH C.A.LOVE,K.HARLOS,N.MAVADDAT,S.J.DAVIS,D.I.STUART,AUTH 2 E.Y.JONES,R.M.ESNOUFTITL THE LIGAND-BINDING FACE OF THE SEMAPHORINSTITL 2 REVEALED BY THE HIGH-RESOLUTION CRYSTAL STRUCTURETITL 3 OF SEMA4DREF NAT.STRUCT.BIOL. V. 10 843 2003REFN ISSN 1072-8368PMID 12958590DOI 10.1038/NSB977 Variant Set Distributions Ripley’s K […]
General Structure Information 1xks NUP133 the crystal structure of the n-terminal domain of nup133 reveals a beta-propeller fold common to several nucleoporins 2.35Å AUTH I.C.BERKE,T.BOEHMER,G.BLOBEL,T.U.SCHWARTZTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF NUP133 DOMAINS REVEALSTITL 2 MODULAR BUILDING BLOCKS OF THE NUCLEAR PORE COMPLEX.REF J.CELL BIOL. V. 167 591 2004REFN ISSN 0021-9525PMID 15557116DOI 10.1083/JCB.200408109 Variant Set Distributions […]
General Structure Information 2w18 PALB2 crystal structure of the c-terminal wd40 domain of human palb2 1.9Å AUTH A.W.OLIVER,S.SWIFT,C.J.LORD,A.ASHWORTH,L.H.PEARLTITL STRUCTURAL BASIS FOR RECRUITMENT OF BRCA2 BY PALB2REF EMBO REP. V. 10 990 2009REFN ISSN 1469-221XPMID 19609323DOI 10.1038/EMBOR.2009.126 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4l7d KEAP1 structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid 2.25Å AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4o2w HERC1 crystal structure of the third rcc1-like domain of herc1 2.0Å AUTH J.HU,A.DONG,Y.LI,J.R.WALKER,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONG,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE THIRD RCC1-LIKE DOMAIN OF HERC1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fww MST1R crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase 1.85Å AUTH K.L.CHAO,I.W.TSAI,C.CHEN,O.HERZBERGTITL CRYSTAL STRUCTURE OF THE SEMA-PSI EXTRACELLULAR DOMAIN OFTITL 2 HUMAN RON RECEPTOR TYROSINE KINASE.REF PLOS ONE V. 7 41912 2012REFN ESSN 1932-6203PMID 22848655DOI 10.1371/JOURNAL.PONE.0041912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]