General Structure Information
| PDB ID | 4l7d |
| HGNC Gene Label(s) | KEAP1 |
| Structure Name | structure of keap1 kelch domain with (1s,2r)-2-{[(1s)-5-methyl-1-[(1- oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin- 2(1h)-yl]carbonyl}cyclohexanecarboxylic acid |
| Resolution | 2.25Å |
| Reference | AUTH E.JNOFF,C.ALBRECHT,J.J.BARKER,O.BARKER,E.BEAUMONT,AUTH 2 S.BROMIDGE,F.BROOKFIELD,M.BROOKS,C.BUBERT,T.CESKA,V.CORDEN,AUTH 3 G.DAWSON,S.DUCLOS,T.FRYATT,C.GENICOT,E.JIGOREL,J.KWONG,AUTH 4 R.MAGHAMES,I.MUSHI,R.PIKE,Z.A.SANDS,M.A.SMITH,C.C.STIMSON,AUTH 5 J.P.COURADETITL BINDING MODE AND STRUCTURE-ACTIVITY RELATIONSHIPS AROUNDTITL 2 DIRECT INHIBITORS OF THE NRF2-KEAP1 COMPLEX.REF CHEMMEDCHEM V. 9 699 2014REFN ISSN 1860-7179PMID 24504667DOI 10.1002/CMDC.201300525 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 284 |
| Number Of SNVs | 60 |
| Number Of Permutations | 6342 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.197 |
| p-value | 0.032 |
COSMIC
| Number Of Residues | 284 |
| Number Of SNVs | 11 |
| Number Of Permutations | 1364 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.127 |
| p-value | 0.301 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 11 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.073 |
| p-value | 0.162 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
