General Structure Information
| PDB ID | 4fww |
| HGNC Gene Label(s) | MST1R |
| Structure Name | crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase |
| Resolution | 1.85Å |
| Reference | AUTH K.L.CHAO,I.W.TSAI,C.CHEN,O.HERZBERGTITL CRYSTAL STRUCTURE OF THE SEMA-PSI EXTRACELLULAR DOMAIN OFTITL 2 HUMAN RON RECEPTOR TYROSINE KINASE.REF PLOS ONE V. 7 41912 2012REFN ESSN 1932-6203PMID 22848655DOI 10.1371/JOURNAL.PONE.0041912 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 513 |
| Number Of SNVs | 150 |
| Number Of Permutations | 36351 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.016 |
| p-value | 0.762 |
COSMIC
| Number Of Residues | 513 |
| Number Of SNVs | 6 |
| Number Of Permutations | 813 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.267 |
| p-value | 0.1 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 150 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.175 |
| p-value | 0.178 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 3:49940897 | F>C | A:49 | (17.15, 2.27, 12.31) | |
| 3:49940888 | COSM3824200 COSM3824199 |
G>E | A:52 | (18.32, -4.56, 7.50) |
| 3:49940889 | rs144338909 | G>R | A:52 | (18.32, -4.56, 7.50) |
| 3:49940871 | M>V | A:58 | (9.34, -1.80, 18.07) | |
| 3:49940858 | rs201965059 | E>G | A:62 | (10.61, 5.80, 28.90) |
| 3:49940855 | G>D | A:63 | (13.55, 5.79, 32.85) | |
| 3:49940853 | D>Y | A:64 | (13.63, 6.47, 36.80) | |
| 3:49940850 | R>G | A:65 | (19.28, 7.97, 36.46) | |
| 3:49940828 | V>G | A:72 | (14.72, -2.98, 16.79) | |
| 3:49940816 | N>S | A:76 | (18.98, -13.61, 12.88) | |
| 3:49940814 | R>C | A:77 | (21.39, -8.61, 14.41) | |
| 3:49940807 | rs529137211 | H>R | A:79 | (19.22, -3.45, 15.95) |
| 3:49940765 | rs540212347 | T>M | A:93 | (19.49, -13.58, 17.58) |
| 3:49940749 | D>E | A:98 | (26.04, -19.68, 14.09) | |
| 3:49940751 | D>N | A:98 | (26.04, -19.68, 14.09) | |
| 3:49940747 | COSM3595468 COSM3595469 |
P>L | A:99 | (29.21, -19.76, 15.57) |
| 3:49940742 | rs528120842 | C>G | A:101 | (24.66, -16.88, 18.11) |
| 3:49940735 | COSM1046366 COSM1046367 |
T>M | A:103 | (21.71, -15.58, 22.16) |
| 3:49940730 | rs201288866 | A>T | A:105 | (26.28, -18.77, 23.47) |
| 3:49940712 | P>S | A:111 | (25.39, -27.53, 19.65) | |
| 3:49940708 | H>R | A:112 | (22.24, -25.36, 21.47) | |
| 3:49940705 | G>D | A:113 | (18.45, -27.30, 18.24) | |
| 3:49940700 | P>A | A:115 | (19.47, -25.94, 12.90) | |
| 3:49940678 | V>E | A:122 | (8.79, -11.69, 22.61) | |
| 3:49940661 | A>T | A:128 | (12.15, -4.53, 38.15) | |
| 3:49940654 | P>R | A:130 | (16.06, -2.94, 34.71) | |
| 3:49940624 | Q>P | A:140 | (13.18, -25.13, 21.89) | |
| 3:49940618 | COSM1046360 COSM1046361 |
R>H | A:142 | (15.58, -21.28, 24.61) |
| 3:49940619 | rs370955872 | R>C | A:142 | (15.58, -21.28, 24.61) |
| 3:49940594 | P>L | A:150 | (24.13, 2.71, 32.45) | |
| 3:49940580 | V>M | A:155 | (20.58, 1.84, 27.45) | |
| 3:49940567 | A>V | A:159 | (25.25, -10.17, 28.74) | |
| 3:49940568 | A>S | A:159 | (25.25, -10.17, 28.74) | |
| 3:49940561 | A>V | A:161 | (20.72, -14.76, 30.05) | |
| 3:49940556 | L>F | A:163 | (15.83, -17.75, 30.57) | |
| 3:49940547 | A>T | A:166 | (18.75, -28.49, 31.16) | |
| 3:49940529 | D>N | A:172 | (6.66, -34.02, 29.02) | |
| 3:49940519 | P>L | A:175 | (9.32, -24.71, 32.15) | |
| 3:49940517 | rs151106960 | D>N | A:176 | (12.03, -22.60, 30.23) |
| 3:49940501 | P>L | A:181 | (6.59, -20.07, 15.89) | |
| 3:49940502 | P>S | A:181 | (6.59, -20.07, 15.89) | |
| 3:49940496 | G>R | A:183 | (2.91, -16.59, 18.32) | |
| 3:49940490 | rs55633379 | R>C | A:185 | (1.61, -10.84, 22.03) |
| 3:49940477 | V>A | A:189 | (2.99, -8.68, 36.53) | |
| 3:49940462 | A>D | A:194 | (8.10, -11.32, 41.85) | |
| 3:49940463 | A>T | A:194 | (8.10, -11.32, 41.85) | |
| 3:49940456 | Y>C | A:196 | (4.79, -13.85, 38.47) | |
| 3:49940448 | V>M | A:199 | (2.53, -16.21, 28.24) | |
| 3:49940430 | rs377677068 | A>T | A:205 | (0.79, -30.16, 16.22) |
| 3:49940424 | COSM3824194 COSM3824193 |
V>M | A:207 | (4.59, -26.37, 18.01) |
| 3:49940402 | R>H | A:214 | (1.60, -25.34, 27.68) | |
| 3:49940403 | rs149238234 | R>C | A:214 | (1.60, -25.34, 27.68) |
| 3:49940394 | rs150176814 | S>P | A:217 | (1.08, -19.03, 30.82) |
| 3:49940390 | I>N | A:218 | (1.07, -17.54, 34.92) | |
| 3:49940391 | I>L | A:218 | (1.07, -17.54, 34.92) | |
| 3:49940388 | R>G | A:219 | (5.66, -19.23, 32.30) | |
| 3:49940366 | S>L | A:226 | (18.10, -19.95, 35.18) | |
| 3:49940363 | G>V | A:227 | (14.71, -19.25, 34.42) | |
| 3:49940358 | rs143724913 | A>T | A:229 | (9.57, -21.62, 37.68) |
| 3:49940354 | rs370892965 | P>R | A:230 | (9.23, -25.03, 38.12) |
| 3:49940355 | P>A | A:230 | (9.23, -25.03, 38.12) | |
| 3:49940333 | V>A | A:237 | (-5.36, -26.39, 22.74) | |
| 3:49940327 | P>H | A:239 | (-4.51, -32.59, 22.03) | |
| 3:49940312 | S>F | A:244 | (-8.89, -27.84, 13.85) | |
| 3:49940309 | rs373496497 | Y>C | A:245 | (-9.67, -24.00, 17.88) |
| 3:49940307 | S>G | A:246 | (-6.36, -21.79, 16.04) | |
| 3:49940303 | I>T | A:247 | (-5.87, -19.22, 19.42) | |
| 3:49940294 | V>A | A:250 | (-3.94, -9.20, 18.82) | |
| 3:49940295 | V>M | A:250 | (-3.94, -9.20, 18.82) | |
| 3:49940276 | G>E | A:256 | (-5.42, -3.29, 37.46) | |
| 3:49940274 | rs528072153 | A>T | A:257 | (-6.42, -6.59, 38.83) |
| 3:49940246 | rs372755312 | P>L | A:266 | (-12.68, -20.31, 16.03) |
| 3:49940231 | D>V | A:271 | (-17.95, -24.36, 13.76) | |
| 3:49940212 | rs375394541 | H>Q | A:277 | (-15.03, -15.11, 17.60) |
| 3:49940199 | rs373567723 | R>W | A:282 | (-10.73, -11.10, 33.51) |
| 3:49940190 | rs563414275 | A>T | A:285 | (-2.77, -9.74, 38.37) |
| 3:49940173 | L>F | A:290 | (-5.34, -19.80, 35.20) | |
| 3:49940171 | G>D | A:291 | (-9.29, -20.66, 37.54) | |
| 3:49940165 | Y>C | A:293 | (-9.28, -17.85, 31.31) | |
| 3:49940162 | R>Q | A:294 | (-13.24, -16.04, 33.83) | |
| 3:49940163 | R>W | A:294 | (-13.24, -16.04, 33.83) | |
| 3:49940156 | rs143752852 | L>P | A:296 | (-16.13, -11.38, 26.80) |
| 3:49940150 | L>R | A:298 | (-15.54, -8.49, 21.95) | |
| 3:49940139 | F>L | A:302 | (-21.57, 0.15, 9.72) | |
| 3:49940100 | G>R | A:315 | (-25.83, -4.54, 11.84) | |
| 3:49940090 | Y>S | A:318 | (-17.03, -5.02, 10.65) | |
| 3:49940081 | rs199936316 | L>P | A:321 | (-9.14, -7.63, 16.44) |
| 3:49940078 | rs2230593 | R>Q | A:322 | (-6.06, -6.13, 12.54) |
| 3:49940079 | R>W | A:322 | (-6.06, -6.13, 12.54) | |
| 3:49940064 | rs200757776 | A>T | A:327 | (-6.31, 4.36, 27.10) |
| 3:49940057 | V>A | A:329 | (-10.29, 8.85, 28.07) | |
| 3:49940058 | V>L | A:329 | (-10.29, 8.85, 28.07) | |
| 3:49940040 | T>A | A:335 | (-19.11, 12.73, 28.27) | |
| 3:49940037 | rs146988970 | E>K | A:336 | (-19.12, 11.16, 23.83) |
| 3:49940022 | COSM4118658 COSM4118659 |
E>K | A:341 | (-11.67, 12.92, 33.25) |
| 3:49940018 | G>D | A:342 | (-9.49, 8.69, 32.77) | |
| 3:49940000 | G>E | A:348 | (-10.70, -1.47, 18.28) | |
| 3:49939993 | rs199531010 | F>L | A:350 | (-12.91, -4.85, 15.14) |
| 3:49939988 | T>I | A:352 | (-15.13, -8.33, 7.72) | |
| 3:49939985 | G>D | A:353 | (-12.93, -11.20, 6.90) | |
| 3:49939965 | COSM2850813 COSM2850812 |
V>M | A:360 | (-21.78, -2.37, 1.95) |
| 3:49939958 | P>L | A:362 | (-16.54, 0.05, 6.38) | |
| 3:49939947 | V>I | A:366 | (-12.99, 1.99, 15.80) | |
| 3:49939943 | C>Y | A:367 | (-14.95, -0.09, 18.87) | |
| 3:49939938 | F>L | A:369 | (-14.82, -2.25, 23.88) | |
| 3:49939932 | I>V | A:371 | (-11.77, -1.65, 31.14) | |
| 3:49939922 | L>R | A:374 | (-15.19, -5.15, 29.74) | |
| 3:49939917 | T>A | A:376 | (-19.39, -5.43, 34.99) | |
| 3:49939892 | rs367939408 | R>H | A:384 | (-25.18, -15.08, 33.62) |
| 3:49939860 | R>G | A:395 | (-21.60, -23.39, 26.62) | |
| 3:49939856 | R>Q | A:396 | (-18.07, -23.68, 32.52) | |
| 3:49939850 | rs199980524 | L>P | A:398 | (-13.43, -22.53, 27.38) |
| 3:49939848 | D>N | A:399 | (-15.09, -26.77, 24.70) | |
| 3:49939843 | F>L | A:400 | (-10.72, -23.99, 23.53) | |
| 3:49939837 | Q>H | A:402 | (-12.30, -26.93, 29.51) | |
| 3:49939835 | rs371024286 | S>L | A:403 | (-14.30, -30.72, 29.13) |
| 3:49939830 | rs570769592 | S>G | A:405 | (-19.88, -28.01, 30.94) |
| 3:49939820 | P>L | A:408 | (-22.90, -25.10, 37.82) | |
| 3:49939814 | rs138579438 | P>L | A:410 | (-17.41, -28.86, 36.75) |
| 3:49936692 | G>D | A:412 | (-17.12, -32.99, 32.49) | |
| 3:49936693 | G>C | A:412 | (-17.12, -32.99, 32.49) | |
| 3:49936683 | COSM1728706 COSM1728705 |
A>V | A:415 | (-22.11, -32.34, 39.19) |
| 3:49936659 | rs376534011 | R>H | A:423 | (-17.33, -18.44, 41.19) |
| 3:49936660 | R>C | A:423 | (-17.33, -18.44, 41.19) | |
| 3:49936644 | L>P | A:428 | (-17.45, -18.27, 27.76) | |
| 3:49936623 | rs200724473 | R>H | A:435 | (-20.54, -1.26, 22.00) |
| 3:49936616 | D>E | A:437 | (-17.87, 2.56, 14.26) | |
| 3:49936608 | rs2230592 | N>S | A:440 | (-20.83, 6.13, 11.05) |
| 3:49936594 | P>A | A:445 | (-11.57, 2.67, 2.01) | |
| 3:49936581 | T>I | A:449 | (-2.45, -1.82, 10.23) | |
| 3:49936563 | R>H | A:455 | (-5.78, 12.08, 28.59) | |
| 3:49936564 | rs199940178 | R>C | A:455 | (-5.78, 12.08, 28.59) |
| 3:49936551 | V>A | A:459 | (-8.49, 15.72, 23.43) | |
| 3:49936552 | V>I | A:459 | (-8.49, 15.72, 23.43) | |
| 3:49936548 | rs149702837 | T>I | A:460 | (-8.89, 11.43, 22.79) |
| 3:49936542 | A>V | A:462 | (-6.10, 8.27, 17.04) | |
| 3:49936543 | rs139493185 | A>S | A:462 | (-6.10, 8.27, 17.04) |
| 3:49936537 | COSM3365230 COSM3365231 |
M>L | A:464 | (-5.10, 5.43, 12.62) |
| 3:49936533 | rs34564898 | G>D | A:465 | (-2.13, 2.88, 10.54) |
| 3:49936519 | COSM1046351 COSM1046352 |
R>C | A:470 | (-1.66, 7.05, 4.94) |
| 3:49936422 | L>M | A:476 | (-11.29, 9.24, 19.51) | |
| 3:49936368 | S>G | A:494 | (7.48, 2.12, 0.62) | |
| 3:49936356 | rs148258933 | V>M | A:498 | (2.10, 0.42, 9.38) |
| 3:49936349 | COSM4118652 COSM4118653 |
R>Q | A:500 | (-0.58, -5.71, 14.73) |
| 3:49936350 | R>W | A:500 | (-0.58, -5.71, 14.73) | |
| 3:49936344 | rs149591175 | V>I | A:502 | (2.93, 1.40, 18.23) |
| 3:49936338 | rs34350470 | R>C | A:504 | (4.76, 7.55, 24.24) |
| 3:49936328 | D>V | A:507 | (6.68, 14.08, 22.42) | |
| 3:49936322 | rs377146279 | L>Q | A:509 | (4.32, 7.77, 18.48) |
| 3:49936317 | rs138805980 | F>L | A:511 | (4.54, 4.29, 13.89) |
| 3:49936301 | Q>R | A:516 | (12.85, 1.90, 7.63) | |
| 3:49936112 | rs200821496 | V>L | A:520 | (5.22, 10.62, 14.70) |
| 3:49936108 | P>L | A:521 | (4.31, 13.99, 16.11) | |
| 3:49936106 | I>L | A:522 | (1.78, 12.63, 20.19) | |
| 3:49936102 | rs2230590 | Q>R | A:523 | (0.97, 17.30, 20.46) |
| 3:49936103 | rs141097970 | Q>E | A:523 | (0.97, 17.30, 20.46) |
| 3:49936099 | G>V | A:524 | (1.51, 17.36, 15.85) | |
| 3:49936076 | T>A | A:532 | (-2.20, 31.55, 7.08) | |
| 3:49936066 | R>H | A:535 | (-3.25, 27.52, 7.50) | |
| 3:49936067 | rs201544530 COSM2850785 COSM2850784 |
R>G | A:535 | (-3.25, 27.52, 7.50) |
| 3:49936050 | W>C | A:540 | (-8.40, 20.83, 15.85) | |
| 3:49936049 | H>Y | A:541 | (-8.40, 22.68, 20.54) | |
| 3:49936042 | rs376462242 | M>R | A:543 | (-2.28, 22.50, 18.64) |
| 3:49936043 | M>V | A:543 | (-2.28, 22.50, 18.64) | |
| 3:49936020 | N>K | A:550 | (4.06, 37.70, 10.88) | |
| 3:49936013 | rs374311934 | G>S | A:553 | (2.24, 30.29, 17.66) |
| 3:49936006 | Q>P | A:555 | (1.02, 33.07, 24.59) | |
| 3:49935999 | E>D | A:557 | (6.62, 32.32, 19.91) | |
| 3:49935995 | P>A | A:559 | (3.68, 37.76, 24.29) | |
| 3:49935991 | rs369882414 | G>D | A:560 | (1.14, 40.63, 22.91) |
| 3:49935976 | rs144558604 | D>A | A:565 | (-10.73, 35.76, 18.03) |
| 3:49935968 | P>S | A:568 | (-6.76, 40.14, 9.49) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 3:49939965 | COSM2850812 | V>M | A:360 | (-21.78, -2.37, 1.95) |
| 3:49939952 | COSM1753286 | S>Y | A:364 | (-12.12, -0.29, 9.04) |
| 3:49939859 | COSM396041 | R>Q | A:395 | (-21.60, -23.39, 26.62) |
| 3:49936537 | COSM3365230 | M>V | A:464 | (-5.10, 5.43, 12.62) |
| 3:49936519 | COSM1046351 | R>C | A:470 | (-1.66, 7.05, 4.94) |
| 3:49936305 | COSM3660617 | D>H | A:515 | (13.62, -1.66, 6.52) |