General Structure Information
| PDB ID | 2w18 |
| HGNC Gene Label(s) | PALB2 |
| Structure Name | crystal structure of the c-terminal wd40 domain of human palb2 |
| Resolution | 1.9Å |
| Reference | AUTH A.W.OLIVER,S.SWIFT,C.J.LORD,A.ASHWORTH,L.H.PEARLTITL STRUCTURAL BASIS FOR RECRUITMENT OF BRCA2 BY PALB2REF EMBO REP. V. 10 990 2009REFN ISSN 1469-221XPMID 19609323DOI 10.1038/EMBOR.2009.126 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 306 |
| Number Of SNVs | 91 |
| Number Of Permutations | 22822 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.241 |
| p-value | 0.808 |
ClinVar
COSMIC
| Number Of Residues | 306 |
| Number Of SNVs | 3 |
| Number Of Permutations | 170 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.667 |
| p-value | 0.941 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 91 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.254 |
| p-value | 0.432 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 91 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.334 |
| p-value | 0.509 |