4GQB.B | WDR77

General Structure Information

PDB ID	4gqb
HGNC Gene Label(s)	WDR77
Structure Name	crystal structure of the human prmt5:mep50 complex
Resolution	2.06Å
Reference	AUTH S.ANTONYSAMY,Z.BONDAY,R.M.CAMPBELL,B.DOYLE,Z.DRUZINA,AUTH 2 T.GHEYI,B.HAN,L.N.JUNGHEIM,Y.QIAN,C.RAUCH,M.RUSSELL,AUTH 3 J.M.SAUDER,S.R.WASSERMAN,K.WEICHERT,F.S.WILLARD,A.ZHANG,AUTH 4 S.EMTAGETITL CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 109 17960 2012REFN ISSN 0027-8424PMID 23071334DOI 10.1073/PNAS.1209814109

Variant Set Distributions

ExAC Variants

Number Of Residues	303
Number Of SNVs	66
Number Of Permutations	22235
Optimal Distance Threshold	8.0
K Statistic	0.038
p-value	0.848

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
1:111991731		P>A	B:21	(-4.10, -122.27, -23.38)
1:111991716		C>S	B:26	(-12.41, -115.96, -17.64)
1:111991694	rs554247846	A>D	B:33	(-20.28, -114.33, -31.47)
1:111991405		A>V	B:46	(-17.06, -111.80, -25.74)
1:111991370		L>F	B:58	(-11.34, -112.96, -29.44)
1:111991351	rs374674543	P>L	B:64	(-16.76, -127.25, -30.95)
1:111991345		A>V	B:66	(-15.78, -127.47, -25.18)
1:111991340		P>A	B:68	(-17.67, -122.05, -23.03)
1:111991336		N>S	B:69	(-14.07, -124.80, -20.93)
1:111991324		C>Y	B:73	(-9.00, -123.40, -25.91)
1:111991308		Q>H	B:78	(-8.49, -109.78, -23.10)
1:111991309	rs375007868	Q>R	B:78	(-8.49, -109.78, -23.10)
1:111991301		A>S	B:81	(-13.14, -103.50, -25.62)
1:111991286		L>V	B:86	(-17.08, -111.34, -35.03)
1:111991282		T>I	B:87	(-16.04, -111.65, -39.36)
1:111991277	rs370256607	V>I	B:89	(-10.75, -112.50, -42.73)
1:111991266		R>S	B:92	(-6.76, -116.57, -39.96)
1:111991262		I>V	B:94	(-10.51, -112.32, -36.58)
1:111991259		L>V	B:95	(-12.88, -107.93, -38.67)
1:111991252		A>V	B:97	(-16.77, -104.57, -33.76)
1:111991241		G>S	B:101	(-14.59, -97.33, -32.65)
1:111990178		L>V	B:108	(-4.88, -117.27, -36.26)
1:111990154		V>I	B:116	(-1.86, -111.44, -33.12)
1:111990148		K>E	B:118	(-2.89, -106.30, -37.01)
1:111990126		D>G	B:125	(-16.93, -90.83, -33.74)
1:111990121	COSM3934008	I>V	B:127	(-20.37, -98.23, -30.47)
1:111990104		S>R	B:132	(-19.17, -107.29, -43.59)
1:111990058		C>R	B:148	(-21.25, -93.70, -40.41)
1:111989763		I>M	B:149	(-21.44, -96.83, -43.62)
1:111989759		V>F	B:151	(-15.30, -99.01, -47.26)
1:111989753		D>N	B:153	(-7.96, -101.80, -47.82)
1:111989743		Q>P	B:156	(-2.61, -100.48, -47.18)
1:111989723		Y>N	B:163	(-20.25, -94.00, -47.91)
1:111989719		R>Q	B:164	(-22.99, -89.06, -42.27)
1:111986734		Q>R	B:169	(-28.14, -96.26, -34.29)
1:111986735	rs377298504	Q>E	B:169	(-28.14, -96.26, -34.29)
1:111986713	rs373098617 COSM1497763	S>C	B:176	(-22.80, -109.60, -51.42)
1:111986711		P>A	B:177	(-22.62, -113.11, -51.37)
1:111986683		C>Y	B:186	(-30.15, -101.27, -41.60)
1:111986536		R>I	B:191	(-33.55, -94.72, -44.50)
1:111986519		T>A	B:197	(-19.67, -98.80, -54.85)
1:111986515		R>H	B:198	(-20.62, -100.84, -59.66)
1:111986513		C>R	B:199	(-23.07, -95.87, -58.35)
1:111986494		Q>R	B:205	(-34.87, -95.98, -49.94)
1:111985998	rs368829864	Y>C	B:213	(-43.28, -102.09, -36.86)
1:111985368	rs192806724	T>I	B:236	(-41.45, -109.72, -38.58)
1:111985366	rs145078783	V>I	B:237	(-39.19, -112.59, -40.96)
1:111985362	rs115748493	S>F	B:238	(-39.27, -110.39, -44.46)
1:111985351		T>A	B:242	(-34.12, -106.25, -55.70)
1:111985321		A>S	B:252	(-44.75, -113.75, -36.99)
1:111985279	rs376404779	H>Y	B:266	(-28.34, -127.32, -46.43)
1:111984668		L>P	B:283	(-37.73, -120.65, -41.00)
1:111984665		D>G	B:284	(-39.41, -122.93, -44.90)
1:111984649		E>D	B:289	(-41.82, -123.05, -37.22)
1:111984651		E>Q	B:289	(-41.82, -123.05, -37.22)
1:111984008	rs527300883	F>L	B:291	(-35.98, -126.32, -34.42)
1:111983975		D>E	B:302	(-24.67, -115.64, -33.47)
1:111983973		A>V	B:303	(-25.86, -118.44, -35.46)
1:111983974		A>T	B:303	(-25.86, -118.44, -35.46)
1:111983971		T>P	B:304	(-23.01, -121.11, -36.71)
1:111983961		P>L	B:307	(-19.11, -127.05, -41.99)
1:111983955	rs201514516	N>S	B:309	(-23.33, -132.00, -39.55)
1:111983951	rs372703223	H>Q	B:310	(-24.49, -129.15, -43.68)
1:111983952		H>R	B:310	(-24.49, -129.15, -43.68)
1:111983937		T>I	B:315	(-26.70, -121.07, -30.43)
1:111983938		T>A	B:315	(-26.70, -121.07, -30.43)
1:111983931		G>V	B:317	(-25.57, -116.14, -25.30)
1:111983917		V>I	B:322	(-22.43, -122.95, -26.47)
1:111983914		V>I	B:323	(-26.47, -124.56, -27.83)
1:111983911		H>Y	B:324	(-23.90, -127.51, -29.97)
1:111983905	COSM414180	V>I	B:326	(-30.20, -131.47, -33.69)
1:111983899		P>S	B:328	(-35.12, -131.05, -38.45)