General Structure Information
| PDB ID | 4o2w |
| HGNC Gene Label(s) | HERC1 |
| Structure Name | crystal structure of the third rcc1-like domain of herc1 |
| Resolution | 2.0Å |
| Reference | AUTH J.HU,A.DONG,Y.LI,J.R.WALKER,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONG,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE THIRD RCC1-LIKE DOMAIN OF HERC1REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 365 |
| Number Of SNVs | 60 |
| Number Of Permutations | 18997 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.149 |
| p-value | 0.278 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 15:63930715 | K>N | C:3996 | (17.53, 89.81, 152.21) | |
| 15:63930708 | V>I | C:3999 | (23.91, 89.09, 145.01) | |
| 15:63930687 | R>G | C:4006 | (25.82, 89.30, 126.69) | |
| 15:63930680 | G>E | C:4008 | (21.33, 88.44, 130.98) | |
| 15:63930671 | rs376973876 | A>V | C:4011 | (21.10, 91.46, 134.92) |
| 15:63930672 | A>S | C:4011 | (21.10, 91.46, 134.92) | |
| 15:63930651 | rs547788211 | M>V | C:4018 | (36.36, 93.09, 134.87) |
| 15:63930638 | A>V | C:4022 | (25.54, 94.48, 142.49) | |
| 15:63930633 | rs372268673 | P>S | C:4024 | (19.78, 94.57, 143.38) |
| 15:63929820 | T>S | C:4039 | (21.54, 82.62, 136.20) | |
| 15:63929807 | Q>H | C:4043 | (12.89, 82.17, 146.26) | |
| 15:63929794 | rs374244666 | V>M | C:4048 | (12.87, 78.56, 140.52) |
| 15:63929772 | rs373281172 | S>N | C:4055 | (19.20, 78.22, 123.82) |
| 15:63928329 | T>I | C:4082 | (15.89, 71.84, 147.55) | |
| 15:63928325 | Q>H | C:4083 | (19.24, 70.57, 145.44) | |
| 15:63928291 | M>V | C:4095 | (18.95, 68.29, 137.11) | |
| 15:63928272 | G>D | C:4101 | (13.19, 63.60, 145.66) | |
| 15:63928221 | N>T | C:4118 | (13.93, 60.48, 124.53) | |
| 15:63928213 | rs373100664 | R>G | C:4121 | (14.75, 70.49, 122.35) |
| 15:63928203 | R>Q | C:4124 | (7.66, 74.07, 130.09) | |
| 15:63928186 | A>T | C:4130 | (12.78, 56.33, 136.38) | |
| 15:63927085 | rs375275073 | M>I | C:4139 | (21.81, 66.71, 141.48) |
| 15:63927080 | rs370877440 | C>S | C:4141 | (25.14, 68.53, 135.22) |
| 15:63927063 | A>T | C:4147 | (24.22, 62.34, 137.91) | |
| 15:63927057 | V>I | C:4149 | (23.17, 60.41, 144.65) | |
| 15:63927024 | N>H | C:4160 | (27.56, 60.68, 126.04) | |
| 15:63927008 | rs374019165 | R>H | C:4165 | (31.21, 60.35, 129.78) |
| 15:63926987 | S>F | C:4172 | (26.89, 52.88, 125.41) | |
| 15:63926957 | rs377473680 | A>V | C:4182 | (30.64, 48.79, 140.47) |
| 15:63926946 | rs185616997 | Y>H | C:4186 | (31.59, 50.43, 147.80) |
| 15:63926940 | I>F | C:4188 | (27.91, 56.82, 146.74) | |
| 15:63926168 | V>A | C:4191 | (28.35, 63.09, 141.79) | |
| 15:63926169 | V>M | C:4191 | (28.35, 63.09, 141.79) | |
| 15:63926138 | V>A | C:4201 | (32.54, 60.66, 147.18) | |
| 15:63926054 | rs199683306 COSM1740199 COSM1740198 |
S>L | C:4229 | (35.33, 51.31, 135.48) |
| 15:63925001 | V>I | C:4235 | (45.86, 60.36, 147.13) | |
| 15:63924985 | G>A | C:4240 | (38.48, 63.31, 154.15) | |
| 15:63924926 | V>M | C:4260 | (42.55, 72.21, 147.92) | |
| 15:63922807 | rs369058833 | R>H | C:4275 | (53.90, 70.67, 142.84) |
| 15:63922808 | rs371244791 | R>C | C:4275 | (53.90, 70.67, 142.84) |
| 15:63922801 | rs375910680 | R>H | C:4277 | (55.28, 67.38, 136.84) |
| 15:63922802 | R>C | C:4277 | (55.28, 67.38, 136.84) | |
| 15:63922798 | rs538859551 | N>S | C:4278 | (53.32, 65.48, 139.48) |
| 15:63922793 | N>H | C:4280 | (48.82, 62.44, 136.63) | |
| 15:63922776 | I>M | C:4285 | (46.79, 74.19, 146.20) | |
| 15:63922777 | rs146258344 | I>T | C:4285 | (46.79, 74.19, 146.20) |
| 15:63922768 | L>P | C:4288 | (45.43, 77.82, 149.56) | |
| 15:63922769 | L>V | C:4288 | (45.43, 77.82, 149.56) | |
| 15:63922766 | A>S | C:4289 | (48.35, 75.73, 152.92) | |
| 15:63922762 | G>E | C:4290 | (47.04, 78.21, 155.32) | |
| 15:63922753 | rs553476502 | I>T | C:4293 | (38.95, 76.22, 151.97) |
| 15:63922742 | A>T | C:4297 | (33.47, 76.53, 142.62) | |
| 15:63922709 | S>A | C:4308 | (36.74, 80.53, 156.89) | |
| 15:63922697 | V>M | C:4312 | (37.02, 84.78, 147.41) | |
| 15:63922684 | G>A | C:4316 | (42.19, 80.56, 135.56) | |
| 15:63922682 | S>G | C:4317 | (40.25, 80.89, 132.63) | |
| 15:63922678 | N>S | C:4318 | (40.01, 85.83, 133.16) | |
| 15:63921014 | L>V | C:4323 | (38.66, 85.19, 137.94) | |
| 15:63920999 | COSM1301297 COSM1301296 |
T>A | C:4328 | (40.94, 89.57, 130.82) |
| 15:63920990 | V>I | C:4331 | (45.26, 83.36, 136.92) | |
| 15:63920957 | G>R | C:4342 | (33.56, 92.99, 153.19) | |
| 15:63920944 | R>Q | C:4346 | (28.12, 83.52, 154.54) | |
| 15:63920945 | R>W | C:4346 | (28.12, 83.52, 154.54) | |
| 15:63920939 | rs561826875 | I>V | C:4348 | (30.74, 80.24, 145.78) |
| 15:63920932 | A>V | C:4350 | (30.57, 78.70, 138.74) | |
| 15:63920927 | COSM1373944 COSM1373943 |
R>C | C:4352 | (30.95, 79.33, 129.58) |
| 15:63920912 | rs576429661 COSM94451 |
A>T | C:4357 | (28.61, 85.92, 145.39) |