Assessment of Structural Intolerance and Durability
General Structure Information 2eel CIDEA solution structure of the cide-n domain of human cell death activator cide-a -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CIDE-N DOMAIN OF HUMANTITL 2 CELL DEATH ACTIVATOR CIDE-AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wal GADD45G crystal structure of human gadd45gamma 2.4Å AUTH S.BHATTACHARYA,J.J.MUELLER,Y.ROSKE,A.P.TURNBULL,C.QUEDENAU,AUTH 2 F.GOTZ,K.BUSSOW,U.HEINEMANNTITL THE CRYSTAL STRUCTURE OF HUMAN GADD45GAMMAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4o7q AIM2 crystal structure of the f27g aim2 pyrin domain mutant and similarities of its self-association to ded/ded interactions 1.82Å AUTH A.LU,V.KABALEESWARAN,T.FU,V.G.MAGUPALLI,H.WUTITL CRYSTAL STRUCTURE OF THE F27G AIM2 PYD MUTANT ANDTITL 2 SIMILARITIES OF ITS SELF-ASSOCIATION TO DED/DEDTITL 3 INTERACTIONS.REF J.MOL.BIOL. V. 426 1420 2014REFN ISSN 0022-2836PMID 24406744DOI 10.1016/J.JMB.2013.12.029 Variant Set Distributions […]
General Structure Information 1wwy TXNL1 solution structure of the duf1000 domain of a thioredoxin-like protein 1 -1.0Å AUTH A.K.GORONCY,S.KOSHIBA,N.TOCHIO,T.TOMIZAWA,M.INOUE,A.TANAKA,AUTH 2 S.SUGANO,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL DUF1000 DOMAIN OF THETITL 2 HUMAN THIOREDOXIN-LIKE 1 PROTEIN.REF PROTEINS V. 78 2176 2010REFN ISSN 0887-3585PMID 20455272DOI 10.1002/PROT.22719 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3dxc APBB1 crystal structure of the intracellular domain of human app in complex with fe65-ptb2 2.1Å AUTH J.RADZIMANOWSKI,B.SIMON,M.SATTLER,K.BEYREUTHER,AUTH 2 I.SINNING,K.WILDTITL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THETITL 2 AMYLOID PRECURSOR PROTEIN IN COMPLEX WITHTITL 3 FE65-PTB2.REF EMBO REP. V. 9 1134 2008REFN ISSN 1469-221XPMID 18833287DOI 10.1038/EMBOR.2008.188 Variant Set Distributions Mapped Variants
General Structure Information 3bqr DAPK3 crystal structure of human death associated protein kinase 3 (dapk3) in complex with an imidazo-pyridazine ligand 1.75Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,O.FEDOROV,F.NIESEN,A.C.W.PIKE,AUTH 2 E.S.PILKA,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN DEATH ASSOCIATED PROTEIN KINASE 3TITL 2 (DAPK3) IN COMPLEX WITH AN IMIDAZO-PYRIDAZINE LIGAND.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4bej DNM1L nucleotide-free dynamin 1-like protein (dnm1l, drp1, dlp1) 3.48Å AUTH C.FROHLICH,S.GRABIGER,D.SCHWEFEL,K.FAELBER,E.ROSENBAUM,AUTH 2 J.MEARS,O.ROCKS,O.DAUMKETITL STRUCTURAL INSIGHTS INTO OLIGOMERIZATION AND MITOCHONDRIALTITL 2 REMODELLING OF DYNAMIN 1-LIKE PROTEIN.REF EMBO J. V. 32 1280 2013REFN ISSN 0261-4189PMID 23584531DOI 10.1038/EMBOJ.2013.74 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cru PDCD5 solution structure of programmed cell death 5 -1.0Å AUTH T.NAGASHIMA,K.IZUMI,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF PROGRAMMED CELL DEATH 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1lcy HTRA2 crystal structure of the mitochondrial serine protease htra2 2.0Å AUTH W.LI,S.M.SRINIVASULA,J.CHAI,P.LI,J.W.WU,Z.ZHANG,E.S.ALNEMRI,AUTH 2 Y.SHITITL STRUCTURAL INSIGHTS INTO THE PRO-APOPTOTIC FUNCTION OFTITL 2 MITOCHONDRIAL SERINE PROTEASE HTRA2/OMI.REF NAT.STRUCT.BIOL. V. 9 436 2002REFN ISSN 1072-8368PMID 11967569DOI 10.1038/NSB795 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k86 FOXO3 solution structure of foxo3a forkhead domain -1.0Å AUTH F.WANG,C.B.MARSHALL,K.YAMAMOTO,G.Y.LI,M.J.PLEVIN,AUTH 2 H.YOU,T.W.MAK,M.IKURATITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF ANTITL 2 INTRAMOLECULAR INTERACTION IN FOXO3A AND ITSTITL 3 BINDING WITH P53.REF J.MOL.BIOL. V. 384 590 2008REFN ISSN 0022-2836PMID 18824006DOI 10.1016/J.JMB.2008.09.025 Variant Set Distributions Mapped Variants