Assessment of Structural Intolerance and Durability
General Structure Information 3r8k HEBP2 crystal structure of human soul protein (hexagonal form) 2.85Å AUTH E.AMBROSI,S.CAPALDI,M.BOVI,G.SACCOMANI,M.PERDUCA,H.L.MONACOTITL STRUCTURAL CHANGES IN THE BH3 DOMAIN OF SOUL PROTEIN UPONTITL 2 INTERACTION WITH THE ANTI-APOPTOTIC PROTEIN BCL-XL.REF BIOCHEM.J. V. 438 291 2011REFN ISSN 0264-6021PMID 21639858DOI 10.1042/BJ20110257 Variant Set Distributions Mapped Variants
General Structure Information 1q7s PTRH2 crystal structure of bit1 2.0Å AUTH J.M.DE PEREDA,W.F.WAAS,Y.JAN,E.RUOSLAHTI,AUTH 2 P.SCHIMMEL,J.PASCUALTITL CRYSTAL STRUCTURE OF A HUMAN PEPTIDYL-TRNATITL 2 HYDROLASE REVEALS A NEW FOLD AND SUGGESTS BASISTITL 3 FOR A BIFUNCTIONAL ACTIVITY.REF J.BIOL.CHEM. V. 279 8111 2004REFN ISSN 0021-9258PMID 14660562DOI 10.1074/JBC.M311449200 Variant Set Distributions Mapped Variants
General Structure Information 3bin EPB41L3 structure of the dal-1 and tslc1 (372-383) complex 2.3Å AUTH R.D.BUSAM,A.-G.THORSELL,A.FLORES,M.HAMMARSTROM,C.PERSSON,AUTH 2 B.OBRINK,B.M.HALLBERGTITL STRUCTURAL BASIS OF TUMOR SUPPRESSOR IN LUNG CANCER 1TITL 2 (TSLC1) BINDING TO DIFFERENTIALLY EXPRESSED INTITL 3 ADENOCARCINOMA OF THE LUNG (DAL-1/4.1B)REF J.BIOL.CHEM. V. 286 4511 2011REFN ISSN 0021-9258PMID 21131357DOI 10.1074/JBC.M110.174011 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2kn6 PYCARD structure of full-length human asc (apoptosis-associated speck-like protein containing a card) -1.0Å AUTH E.DE ALBATITL STRUCTURE AND INTERDOMAIN DYNAMICS OF APOPTOSIS-ASSOCIATEDTITL 2 SPECK-LIKE PROTEIN CONTAINING A CARD (ASC)REF J.BIOL.CHEM. V. 284 32932 2009REFN ISSN 0021-9258PMID 19759015DOI 10.1074/JBC.M109.024273 Variant Set Distributions Mapped Variants
General Structure Information 1d4b CIDEB cide-n domain of human cide-b -1.0Å AUTH A.A.LUGOVSKOY,P.ZHOU,J.J.CHOU,J.S.MCCARTY,P.LI,AUTH 2 G.WAGNERTITL SOLUTION STRUCTURE OF THE CIDE-N DOMAIN OF CIDE-BTITL 2 AND A MODEL FOR CIDE-N/CIDE-N INTERACTIONS IN THETITL 3 DNA FRAGMENTATION PATHWAY OF APOPTOSIS.REF CELL(CAMBRIDGE,MASS.) V. 99 747 1999REFN ISSN 0092-8674PMID 10619428DOI 10.1016/S0092-8674(00)81672-4 Variant Set Distributions Mapped Variants
General Structure Information 2kzs DAXX daxx helical bundle (dhb) domain -1.0Å AUTH E.ESCOBAR-CABRERA,D.K.LAU,S.GIOVINAZZI,A.M.ISHOV,AUTH 2 L.P.MCINTOSHTITL STRUCTURAL CHARACTERIZATION OF THE DAXX N-TERMINAL HELICALTITL 2 BUNDLE DOMAIN AND ITS COMPLEX WITH RASSF1C.REF STRUCTURE V. 18 1642 2010REFN ISSN 0969-2126PMID 21134643DOI 10.1016/J.STR.2010.09.016 Variant Set Distributions Mapped Variants
General Structure Information 3ceg BIRC6 crystal structure of the ubc domain of baculoviral iap repeat- containing protein 6 2.01Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4mpm NGB wild-type human neuroglobin 1.74Å AUTH B.G.GUIMARAES,D.HAMDANE,C.LECHAUVE,M.C.MARDEN,AUTH 2 B.GOLINELLI-PIMPANEAUTITL THE CRYSTAL STRUCTURE OF WILD-TYPE HUMAN BRAIN NEUROGLOBINTITL 2 REVEALS FLEXIBILITY OF THE DISULFIDE BOND THAT REGULATESTITL 3 OXYGEN AFFINITY.REF ACTA CRYSTALLOGR.,SECT.D V. 70 1005 2014REFN ISSN 0907-4449PMID 24699645DOI 10.1107/S1399004714000078 Variant Set Distributions Mapped Variants
General Structure Information 2jfl SLK crystal structure of human ste20-like kinase ( diphosphorylated form) bound to 5- amino-3-((4-( aminosulfonyl)phenyl)amino)-n-(2,6- difluorophenyl)-1h-1,2, 4-triazole-1-carbothioamide 2.2Å AUTH A.C.W.PIKE,P.RELLOS,F.H.NIESEN,A.TURNBULL,A.W.OLIVER,AUTH 2 S.A.PARKER,B.E.TURK,L.H.PEARL,S.KNAPPTITL ACTIVATION SEGMENT DIMERIZATION: A MECHANISM FOR KINASETITL 2 AUTOPHOSPHORYLATION OF NON-CONSENSUS SITES.REF EMBO J. V. 27 704 2008REFN ISSN 0261-4189PMID 18239682DOI 10.1038/EMBOJ.2008.8 Variant Set Distributions Mapped Variants
General Structure Information 3q2e BRWD1 crystal structure of the second bromodomain of human bromodomain and wd repeat-containing protein 1 isoform a (wdr9) 1.74Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants