Assessment of Structural Intolerance and Durability
General Structure Information 2zu6 EIF4A1 crystal structure of the eif4a-pdcd4 complex 2.8Å AUTH J.H.CHANG,Y.H.CHO,S.Y.SOHN,J.M.CHOI,A.KIM,Y.C.KIM,AUTH 2 S.K.JANG,Y.CHOTITL CRYSTAL STRUCTURE OF THE EIF4A-PDCD4 COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 106 3148 2009REFN ISSN 0027-8424PMID 19204291DOI 10.1073/PNAS.0808275106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2v55 RND3 mechanism of multi-site phosphorylation from a rock-i:rhoe complex structure 3.7Å AUTH D.KOMANDER,R.GARG,P.T.C.WAN,A.J.RIDLEY,D.BARFORDTITL MECHANISM OF MULTI-SITE PHOSPHORYLATION FROM ATITL 2 ROCK-I:RHOE COMPLEX STRUCTURE.REF EMBO J. V. 27 3175 2008REFN ISSN 0261-4189PMID 18946488DOI 10.1038/EMBOJ.2008.226 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ygs CASP9 apaf-1 card in complex with prodomain of procaspase-9 2.5Å AUTH H.QIN,S.M.SRINIVASULA,G.WU,T.FERNANDES-ALNEMRI,AUTH 2 E.S.ALNEMRI,Y.SHITITL STRUCTURAL BASIS OF PROCASPASE-9 RECRUITMENT BYTITL 2 THE APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.REF NATURE V. 399 549 1999REFN ISSN 0028-0836PMID 10376594DOI 10.1038/21124 Variant Set Distributions Mapped Variants
General Structure Information 3g76 XIAP crystal structure of xiap-bir3 in complex with a bivalent compound 3.0Å AUTH F.COSSU,M.MILANI,E.MASTRANGELO,P.VACHETTE,AUTH 2 F.SERVIDA,D.LECIS,G.CANEVARI,D.DELIA,C.DRAGO,AUTH 3 V.RIZZO,L.MANZONI,P.SENECI,C.SCOLASTICO,M.BOLOGNESITITL STRUCTURAL BASIS FOR BIVALENT SMAC-MIMETICSTITL 2 RECOGNITION IN THE IAP PROTEIN FAMILYREF J.MOL.BIOL. V. 392 630 2009REFN ISSN 0022-2836PMID 19393243DOI 10.1016/J.JMB.2009.04.033 Variant Set Distributions Mapped Variants
General Structure Information 2bid BID human pro-apoptotic protein bid -1.0Å AUTH J.J.CHOU,H.LI,G.S.SALVESEN,J.YUAN,G.WAGNERTITL SOLUTION STRUCTURE OF BID, AN INTRACELLULARTITL 2 AMPLIFIER OF APOPTOTIC SIGNALING.REF CELL(CAMBRIDGE,MASS.) V. 96 615 1999REFN ISSN 0092-8674PMID 10089877DOI 10.1016/S0092-8674(00)80572-3 Variant Set Distributions Mapped Variants
General Structure Information 2kqs SUMO1 phosphorylation of sumo-interacting motif by ck2 enhances daxx sumo binding activity -1.0Å AUTH C.C.CHANG,M.T.NAIK,Y.S.HUANG,J.C.JENG,P.H.LIAO,H.Y.KUO,AUTH 2 C.C.HO,Y.L.HSIEH,C.H.LIN,N.J.HUANG,N.M.NAIK,C.C.KUNG,AUTH 3 S.Y.LIN,R.H.CHEN,K.S.CHANG,T.H.HUANG,H.M.SHIHTITL STRUCTURAL AND FUNCTIONAL ROLES OF DAXX SIM PHOSPHORYLATIONTITL 2 IN SUMO PARALOG-SELECTIVE BINDING AND APOPTOSIS MODULATION.REF MOL.CELL V. 42 62 2011REFN ISSN 1097-2765PMID 21474068DOI 10.1016/J.MOLCEL.2011.02.022 Variant Set Distributions Mapped Variants
General Structure Information 1mzd GZMK crystal structure of human pro-granzyme k 2.9Å AUTH C.HINK-SCHAUER,E.ESTEBANEZ-PERPINA,E.WILHARM,AUTH 2 P.FUENTES-PRIOR,W.KLINKERT,W.BODE,D.E.JENNETITL THE 2.2-A CRYSTAL STRUCTURE OF HUMAN PRO-GRANZYMETITL 2 K REVEALS A RIGID ZYMOGEN WITH UNUSUAL FEATURESREF J.BIOL.CHEM. V. 277 50923 2002REFN ISSN 0021-9258PMID 12384499DOI 10.1074/JBC.M207962200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1du3 TNFSF10 crystal structure of trail-sdr5 2.2Å AUTH S.-S.CHA,B.-J.SUNG,Y.A.KIM,Y.L.SONG,H.J.KIM,S.KIM,AUTH 2 M.S.LEE,B.-H.OHTITL CRYSTAL STRUCTURE OF TRAIL-DR5 COMPLEX IDENTIFIESTITL 2 A CRITICAL ROLE OF THE UNIQUE FRAME INSERTION INTITL 3 CONFERRING RECOGNITION SPECIFICITYREF J.BIOL.CHEM. V. 275 31171 2000REFN ISSN 0021-9258PMID 10893238DOI 10.1074/JBC.M004414200 Variant Set Distributions Mapped Variants
General Structure Information 2kr6 PSEN1 solution structure of presenilin-1 ctf subunit -1.0Å AUTH V.DOETSCHTITL SOLUTION STRUCTURE OF PRESENILIN-1 CTF SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gub DAPK1 crystal structure of dapkl93g complexed with n6-(2- phenylethyl)adenosine 1.71Å AUTH L.K.MCNAMARA,J.S.SCHAVOCKY,D.M.WATTERSON,AUTH 2 J.S.BRUNZELLETITL CRYSTAL STRUCTURES OF THE DAPK GATEKEEPER MUTANTTITL 2 COMPLEXED WITH N6-MODIFIED ADENOSINE ANALOGS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants