General Structure Information
| PDB ID | 2bid |
| HGNC Gene Label(s) | BID |
| Structure Name | human pro-apoptotic protein bid |
| Resolution | -1.0Å |
| Reference | AUTH J.J.CHOU,H.LI,G.S.SALVESEN,J.YUAN,G.WAGNERTITL SOLUTION STRUCTURE OF BID, AN INTRACELLULARTITL 2 AMPLIFIER OF APOPTOTIC SIGNALING.REF CELL(CAMBRIDGE,MASS.) V. 96 615 1999REFN ISSN 0092-8674PMID 10089877DOI 10.1016/S0092-8674(00)80572-3 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 195 |
| Number Of SNVs | 59 |
| Number Of Permutations | 35926 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.044 |
| p-value | 0.237 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 22:18226770 | G>S | A:10 | (1.66, -19.57, 14.86) | |
| 22:18226764 | rs8190315 | S>G | A:12 | (3.49, -16.26, 8.78) |
| 22:18226755 | rs535265881 | D>N | A:15 | (5.36, -8.45, 5.55) |
| 22:18226743 | T>A | A:19 | (10.81, -5.58, 0.62) | |
| 22:18226728 | F>L | A:24 | (8.32, 1.68, -4.48) | |
| 22:18226699 | N>K | A:33 | (10.52, 15.69, -8.76) | |
| 22:18226691 | R>H | A:36 | (5.24, 12.49, -10.61) | |
| 22:18226692 | R>C | A:36 | (5.24, 12.49, -10.61) | |
| 22:18226688 | R>I | A:37 | (3.68, 9.11, -15.30) | |
| 22:18226689 | rs199617244 | R>G | A:37 | (3.68, 9.11, -15.30) |
| 22:18226676 | A>V | A:41 | (4.19, 3.68, -13.73) | |
| 22:18226677 | rs372024838 | A>T | A:41 | (4.19, 3.68, -13.73) |
| 22:18226671 | G>S | A:43 | (3.83, 0.48, -8.89) | |
| 22:18226665 | E>K | A:45 | (2.81, -4.04, -13.09) | |
| 22:18226655 | V>A | A:48 | (2.05, -8.05, -2.71) | |
| 22:18226647 | P>S | A:51 | (-1.85, -13.55, 2.65) | |
| 22:18226634 | G>D | A:55 | (-12.34, -11.27, -0.03) | |
| 22:18226635 | G>S | A:55 | (-12.34, -11.27, -0.03) | |
| 22:18226619 | Q>R | A:60 | (-16.43, 1.09, -2.14) | |
| 22:18226589 | R>H | A:70 | (-2.12, 16.78, 0.92) | |
| 22:18226590 | rs61757628 | R>C | A:70 | (-2.12, 16.78, 0.92) |
| 22:18226585 | L>F | A:71 | (-0.86, 22.42, 3.41) | |
| 22:18222251 | S>C | A:78 | (6.11, 9.51, 11.94) | |
| 22:18222248 | E>G | A:79 | (1.92, 7.61, 13.84) | |
| 22:18222249 | rs553170594 | E>K | A:79 | (1.92, 7.61, 13.84) |
| 22:18222239 | E>V | A:82 | (3.29, 2.22, 5.21) | |
| 22:18222227 | R>Q | A:86 | (6.02, 6.53, 2.33) | |
| 22:18222228 | rs148107209 | R>W | A:86 | (6.02, 6.53, 2.33) |
| 22:18222221 | I>T | A:88 | (12.96, 5.42, 7.69) | |
| 22:18222215 | R>K | A:90 | (11.73, 11.23, 0.02) | |
| 22:18222212 | H>R | A:91 | (15.53, 11.31, 5.77) | |
| 22:18222207 | rs375433200 COSM1184706 |
A>T | A:93 | (17.74, 7.73, 0.21) |
| 22:18222198 | G>R | A:96 | (23.04, 9.22, -0.38) | |
| 22:18222189 | COSM1580029 | M>V | A:99 | (27.39, 11.59, -0.13) |
| 22:18222185 | rs556890832 | D>G | A:100 | (25.65, 9.84, -5.26) |
| 22:18222182 | rs370897535 | R>H | A:101 | (24.66, 16.36, -7.17) |
| 22:18222183 | rs537058757 | R>C | A:101 | (24.66, 16.36, -7.17) |
| 22:18222170 | rs575351241 | P>L | A:105 | (36.06, 7.22, -11.05) |
| 22:18222167 | G>V | A:106 | (32.81, 6.34, -14.18) | |
| 22:18222164 | rs143734092 | L>P | A:107 | (30.59, 3.51, -10.37) |
| 22:18222161 | V>G | A:108 | (26.81, 5.50, -12.09) | |
| 22:18222141 | rs372763830 | L>F | A:115 | (20.62, -2.96, -13.82) |
| 22:18222134 | N>T | A:117 | (21.81, -6.32, -19.52) | |
| 22:18222131 | T>I | A:118 | (18.16, -5.61, -22.92) | |
| 22:18222125 | R>Q | A:120 | (19.95, -10.77, -21.84) | |
| 22:18222126 | R>W | A:120 | (19.95, -10.77, -21.84) | |
| 22:18222122 | COSM1246110 | S>L | A:121 | (18.02, -6.98, -16.64) |
| 22:18222118 | rs146769173 | E>D | A:122 | (14.88, -9.41, -14.34) |
| 22:18222119 | rs139202406 | E>G | A:122 | (14.88, -9.41, -14.34) |
| 22:18222116 | E>V | A:123 | (18.09, -13.31, -15.43) | |
| 22:18220991 | rs142609840 | R>Q | A:125 | (18.99, -7.13, -12.04) |
| 22:18220992 | R>W | A:125 | (18.99, -7.13, -12.04) | |
| 22:18220935 | M>L | A:144 | (29.30, -10.97, 10.89) | |
| 22:18220915 | rs140738257 | M>I | A:150 | (26.30, -8.98, -0.21) |
| 22:18220916 | rs150084106 | M>T | A:150 | (26.30, -8.98, -0.21) |
| 22:18220917 | M>V | A:150 | (26.30, -8.98, -0.21) | |
| 22:18220893 | A>T | A:158 | (21.07, -0.59, -8.33) | |
| 22:18220885 | K>N | A:160 | (25.05, 4.39, -7.06) | |
| 22:18220886 | K>R | A:160 | (25.05, 4.39, -7.06) | |
| 22:18220880 | A>V | A:162 | (18.60, 4.86, -11.25) | |
| 22:18220881 | A>S | A:162 | (18.60, 4.86, -11.25) | |
| 22:18220871 | rs547322681 | T>M | A:165 | (19.97, 5.29, -16.63) |
| 22:18220863 | L>V | A:168 | (17.33, 0.69, -16.10) | |
| 22:18220859 | L>P | A:169 | (13.09, 3.93, -12.15) | |
| 22:18220857 | rs185077891 | R>C | A:170 | (10.02, -0.92, -14.38) |
| 22:18220854 | D>N | A:171 | (15.34, -2.92, -13.90) | |
| 22:18220851 | V>L | A:172 | (17.10, 0.04, -10.31) | |
| 22:18220848 | rs376912423 | F>V | A:173 | (12.15, 0.26, -7.99) |
| 22:18220816 | rs367829996 | N>K | A:183 | (18.76, -15.37, -0.04) |
| 22:18220818 | N>H | A:183 | (18.76, -15.37, -0.04) | |
| 22:18220811 | rs139212717 | R>H | A:185 | (12.78, -12.81, 1.74) |
| 22:18220812 | rs538615870 | R>C | A:185 | (12.78, -12.81, 1.74) |
| 22:18220802 | V>G | A:188 | (15.15, -5.37, 2.26) | |
| 22:18220784 | rs550005605 | N>T | A:194 | (19.51, 1.49, 9.36) |
| 22:18218357 | G>R | A:195 | (17.18, 3.58, 5.82) | |
| 22:18218353 | rs59225839 | M>T | A:196 | (21.66, 4.24, 3.51) |