Assessment of Structural Intolerance and Durability
General Structure Information 3rsw FABP3 crystal structure of heart fatty acid binding protein (fabp3) 2.6Å AUTH D.F.CARNEY,B.SHANKARAN,P.H.ZWART,J.W.STEBBINS,G.S.PRASADTITL CRYSTAL STRUCTURE OF HEART FATTY ACID BINDING PROTEINTITL 2 (FABP3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ruk CYP17A1 human cytochrome p450 cyp17a1 in complex with abiraterone 2.6Å AUTH N.M.DEVORE,E.E.SCOTTTITL STRUCTURES OF CYTOCHROME P450 17A1 WITH PROSTATE CANCERTITL 2 DRUGS ABIRATERONE AND TOK-001.REF NATURE V. 482 116 2012REFN ISSN 0028-0836PMID 22266943DOI 10.1038/NATURE10743 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jq3 APOC3 structure and dynamics of human apolipoprotein c-iii -1.0Å AUTH C.S.GANGABADAGE,J.ZDUNEK,M.TESSARI,S.NILSSON,AUTH 2 G.OLIVECRONA,S.S.WIJMENGATITL STRUCTURE AND DYNAMICS OF HUMAN APOLIPOPROTEIN CIIIREF J.BIOL.CHEM. V. 283 17416 2008REFN ISSN 0021-9258PMID 18408013DOI 10.1074/JBC.M800756200 Variant Set Distributions Mapped Variants
General Structure Information 1bzk SLC4A1 structural studies on the effects of the deletion in the red cell anion exchanger (band3, ae1) associated with south east asian ovalocytosis. -1.0Å AUTH E.J.CHAMBERS,G.B.BLOOMBERG,S.M.RING,M.J.TANNERTITL STRUCTURAL STUDIES ON THE EFFECTS OF THE DELETIONTITL 2 IN THE RED CELL ANION EXCHANGER (BAND 3, AE1)TITL 3 ASSOCIATED WITH SOUTH EAST ASIAN OVALOCYTOSIS.REF […]
General Structure Information 2oay SERPING1 crystal structure of latent human c1-inhibitor 2.35Å AUTH L.BEINROHR,V.HARMAT,J.DOBO,Z.LORINCZ,P.GAL,P.ZAVODSZKYTITL C1 INHIBITOR SERPIN DOMAIN STRUCTURE REVEALS THE LIKELYTITL 2 MECHANISM OF HEPARIN POTENTIATION AND CONFORMATIONAL DISEASEREF J.BIOL.CHEM. V. 282 21100 2007REFN ISSN 0021-9258PMID 17488724DOI 10.1074/JBC.M700841200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1afo GYPA dimeric transmembrane domain of human glycophorin a, nmr, 20 structures -1.0Å AUTH K.R.MACKENZIE,J.H.PRESTEGARD,D.M.ENGELMANTITL A TRANSMEMBRANE HELIX DIMER: STRUCTURE ANDTITL 2 IMPLICATIONS.REF SCIENCE V. 276 131 1997REFN ISSN 0036-8075PMID 9082985DOI 10.1126/SCIENCE.276.5309.131 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wef BPNT1 human 3(2), 5-bisphosphate nucleotidase 1 (bpnt1) in complex with amp, po4 and magnesium 1.8Å AUTH M.MOCHE,P.SCHUTZ,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 A.JOHANSSON,I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,AUTH 5 M.E.NILSSON,T.NYMAN,C.PERSSON,J.SAGEMARK,AUTH 6 H.SCHUELER,M.I.SIPONEN,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 8 P.NORDLUNDTITL HUMAN 3(2), 5-BISPHOSPHATE NUCLEOTIDASE 1 (TITL 2 BPNT1) IN COMPLEX WITH AMP, PO4 AND MAGNESIUMREF TO BE PUBLISHEDREFN […]
General Structure Information 1hig IFNG three-dimensional structure of recombinant human interferon- gamma. 3.5Å AUTH S.E.EALICK,W.J.COOK,S.VIJAY-KUMAR,M.CARSON,AUTH 2 T.L.NAGABHUSHAN,P.P.TROTTA,C.E.BUGGTITL THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMANTITL 2 INTERFERON-GAMMA.REF SCIENCE V. 252 698 1991REFN ISSN 0036-8075PMID 1902591 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jwa ERBB2 erbb2 transmembrane segment dimer spatial structure -1.0Å AUTH E.V.BOCHAROV,K.S.MINEEV,P.E.VOLYNSKY,Y.S.ERMOLYUK,AUTH 2 E.N.TKACH,A.G.SOBOL,V.V.CHUPIN,M.P.KIRPICHNIKOV,AUTH 3 R.G.EFREMOV,A.S.ARSENIEVTITL SPATIAL STRUCTURE OF THE DIMERIC TRANSMEMBRANETITL 2 DOMAIN OF THE GROWTH FACTOR RECEPTOR ERBB2TITL 3 PRESUMABLY CORRESPONDING TO THE RECEPTOR ACTIVETITL 4 STATEREF J.BIOL.CHEM. V. 283 6950 2008REFN ISSN 0021-9258PMID 18178548DOI 10.1074/JBC.M709202200 Variant Set Distributions Ripley’s K […]
General Structure Information 1xiw CD3D crystal structure of human cd3-e/d dimer in complex with a ucht1 single-chain antibody fragment 1.9Å AUTH K.L.ARNETT,S.C.HARRISON,D.C.WILEYTITL CRYSTAL STRUCTURE OF A HUMAN CD3-EPSILON/DELTATITL 2 DIMER IN COMPLEX WITH A UCHT1 SINGLE-CHAINTITL 3 ANTIBODY FRAGMENT.REF PROC.NATL.ACAD.SCI.USA V. 101 16268 2004REFN ISSN 0027-8424PMID 15534202DOI 10.1073/PNAS.0407359101 Variant Set Distributions Mapped Variants