Assessment of Structural Intolerance and Durability
General Structure Information 1hlg LIPF crystal structure of human gastric lipase 3.0Å AUTH A.ROUSSEL,S.CANAAN,M.P.EGLOFF,M.RIVIERE,L.DUPUIS,R.VERGER,AUTH 2 C.CAMBILLAUTITL CRYSTAL STRUCTURE OF HUMAN GASTRIC LIPASE AND MODEL OFTITL 2 LYSOSOMAL ACID LIPASE, TWO LIPOLYTIC ENZYMES OF MEDICALTITL 3 INTEREST.REF J.BIOL.CHEM. V. 274 16995 1999REFN ISSN 0021-9258PMID 10358049DOI 10.1074/JBC.274.24.16995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2fn4 RRAS the crystal structure of human ras-related protein, rras, in the gdp- bound state 1.65Å AUTH A.P.TURNBULL,J.M.ELKINS,C.GILEADI,N.BURGESS,E.SALAH,AUTH 2 E.PAPAGRIGORIOU,J.DEBRECZENI,F.VON DELFT,J.WEIGELT,AUTH 3 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,D.DOYLETITL THE CRYSTAL STRUCTURE OF HUMAN RAS-RELATED PROTEIN, RRAS, INTITL 2 THE GDP-BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1unc VIL1 solution structure of the human villin c-terminal headpiece subdomain -1.0Å AUTH W.VERMEULEN,P.VANHAESEBROUCK,M.VAN TROYS,AUTH 2 M.VERSCHUEREN,F.FANT,M.GOETHALS,C.AMPE,J.MARTINS,AUTH 3 F.BORREMANSTITL SOLUTION STRUCTURES OF THE C-TERMINAL HEADPIECETITL 2 SUBDOMAINS OF HUMAN VILLIN AND ADVILLIN,TITL 3 EVALUATION OF HEADPIECE F-ACTIN-BINDINGTITL 4 REQUIREMENTSREF PROTEIN SCI. V. 13 1276 2004REFN ISSN 0961-8368PMID 15096633DOI 10.1110/PS.03518104 Variant Set Distributions […]
General Structure Information 1y8o DLAT crystal structure of the pdk3-l2 complex 2.48Å AUTH M.KATO,J.L.CHUANG,S.C.TSO,R.M.WYNN,D.T.CHUANGTITL CRYSTAL STRUCTURE OF PYRUVATE DEHYDROGENASE KINASE 3 BOUNDTITL 2 TO LIPOYL DOMAIN 2 OF HUMAN PYRUVATE DEHYDROGENASE COMPLEX.REF EMBO J. V. 24 1763 2005REFN ISSN 0261-4189PMID 15861126DOI 10.1038/SJ.EMBOJ.7600663 Variant Set Distributions Mapped Variants
General Structure Information 2pfr NAT2 human n-acetyltransferase 2 1.92Å AUTH H.WU,W.TEMPEL,L.DOMBROVSKI,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,D.M.GRANT,AUTH 3 A.N.PLOTNIKOV,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN N-ACETYLTRANSFERASE 2 INTITL 2 COMPLEX WITH COAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3zbf ROS1 structure of human ros1 kinase domain in complex with crizotinib 2.2Å AUTH M.M.AWAD,R.KATAYAMA,M.MCTIGUE,W.LIU,Y.DENG,A.BROOUN,AUTH 2 L.FRIBOULET,D.HUANG,M.D.FALK,S.TIMOFEEVSKI,K.D.WILNER,AUTH 3 E.L.LOCKERMAN,T.M.KHAN,S.MAHMOOD,J.F.GAINOR,S.R.DIGUMARTHY,AUTH 4 J.R.STONE,M.MINO-KENUDSON,J.G.CHRISTENSEN,J.IAFRATE,AUTH 5 J.A.ENGELMAN,A.T.SHAWTITL ACQUIRED RESISTANCE TO CRIZOTINIB FROM A MUTATION INTITL 2 CD74-ROS1REF N.ENGL.J.MED. V. 368 2395 2013REFN ISSN 0028-4793PMID 23724914DOI 10.1056/NEJMOA1215530 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1z6c PROS1 solution structure of an egf pair (egf34) from vitamin k- dependent protein s -1.0Å AUTH T.DRAKENBERG,H.GHASRIANI,E.THULIN,A.MURANYI,AUTH 2 A.ANNILA,J.STENFLOTITL SOLUTION STRUCTURE OF THE CA(2+)-BINDING EGF3-4TITL 2 PAIR FROM VITAMIN K-DEPENDENT PROTEIN S:TITL 3 IDENTIFICATION OF AN UNUSUAL FOLD IN EGF3.REF BIOCHEMISTRY V. 44 8782 2005REFN ISSN 0006-2960PMID 15952784DOI 10.1021/BI050101F Variant Set […]
General Structure Information 4dm8 RARB crystal structure of rarb lbd in complex with 9cis retinoic acid 2.3Å AUTH J.OSZ,Y.BRELIVET,C.PELUSO-ILTIS,V.CURA,S.EILER,M.RUFF,AUTH 2 W.BOURGUET,N.ROCHEL,D.MORASTITL STRUCTURAL BASIS FOR A MOLECULAR ALLOSTERIC CONTROLTITL 2 MECHANISM OF COFACTOR BINDING TO NUCLEAR RECEPTORS.REF PROC.NATL.ACAD.SCI.USA V. 109 E588 2012REFN ISSN 0027-8424PMID 22355136DOI 10.1073/PNAS.1118192109 Variant Set Distributions Mapped Variants
General Structure Information 1jlm ITGAM i-domain from integrin cr3, mn2+ bound 2.0Å AUTH J.O.LEE,L.A.BANKSTON,M.A.ARNAOUT,R.C.LIDDINGTONTITL TWO CONFORMATIONS OF THE INTEGRIN A-DOMAINTITL 2 (I-DOMAIN): A PATHWAY FOR ACTIVATION?REF STRUCTURE V. 3 1333 1995REFN ISSN 0969-2126PMID 8747460DOI 10.1016/S0969-2126(01)00271-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1pq2 CYP2C8 crystal structure of human drug metabolizing cytochrome p450 2c8 2.7Å AUTH G.A.SCHOCH,J.K.YANO,M.R.WESTER,K.J.GRIFFIN,AUTH 2 C.D.STOUT,E.F.JOHNSONTITL STRUCTURE OF HUMAN MICROSOMAL CYTOCHROME P450 2C8.TITL 2 EVIDENCE FOR A PERIPHERAL FATTY ACID BINDING SITEREF J.BIOL.CHEM. V. 279 9497 2004REFN ISSN 0021-9258PMID 14676196DOI 10.1074/JBC.M312516200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]