Assessment of Structural Intolerance and Durability
General Structure Information 1cjl CTSL crystal structure of a cysteine protease proform 2.2Å AUTH R.COULOMBE,P.GROCHULSKI,J.SIVARAMAN,R.MENARD,AUTH 2 J.S.MORT,M.CYGLERTITL STRUCTURE OF HUMAN PROCATHEPSIN L REVEALS THETITL 2 MOLECULAR BASIS OF INHIBITION BY THE PROSEGMENT.REF EMBO J. V. 15 5492 1996REFN ISSN 0261-4189PMID 8896443 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2h2r FCER2 crystal structure of the human cd23 lectin domain, apo form 1.5Å AUTH B.A.WURZBURG,S.S.TARCHEVSKAYA,T.S.JARDETZKYTITL STRUCTURAL CHANGES IN THE LECTIN DOMAIN OF CD23,TITL 2 THE LOW-AFFINITY IGE RECEPTOR, UPON CALCIUMTITL 3 BINDING.REF STRUCTURE V. 14 1049 2006REFN ISSN 0969-2126PMID 16765898DOI 10.1016/J.STR.2006.03.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2v53 SPARC crystal structure of a sparc-collagen complex 3.2Å AUTH E.HOHENESTER,T.SASAKI,C.GIUDICI,R.W.FARNDALE,AUTH 2 H.P.BACHINGERTITL STRUCTURAL BASIS OF SEQUENCE-SPECIFIC COLLAGENTITL 2 RECOGNITION BY SPARC.REF PROC.NATL.ACAD.SCI.USA V. 105 18273 2008REFN ISSN 0027-8424PMID 19011090DOI 10.1073/PNAS.0808452105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rap RAP2A the small g protein rap2 in a non catalytic complex with gtp 2.2Å AUTH J.MENETREY,J.CHERFILSTITL STRUCTURE OF THE SMALL G PROTEIN RAP2 IN ATITL 2 NON-CATALYTIC COMPLEX WITH GTP.REF PROTEINS V. 37 465 1999REFN ISSN 0887-3585PMID 10591105DOI 10.1002/(SICI)1097-0134(19991115)37:33.0.CO;2-O Variant Set Distributions Mapped Variants
General Structure Information 4dqy PARP1 structure of human parp-1 bound to a dna double strand break 3.25Å AUTH M.F.LANGELIER,J.L.PLANCK,S.ROY,J.M.PASCALTITL STRUCTURAL BASIS FOR DNA DAMAGE-DEPENDENTTITL 2 POLY(ADP-RIBOSYL)ATION BY HUMAN PARP-1.REF SCIENCE V. 336 728 2012REFN ISSN 0036-8075PMID 22582261DOI 10.1126/SCIENCE.1216338 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3uyq CA3 hca 3 1.7Å AUTH I.ELDER,Z.FISHER,P.J.LAIPIS,C.TU,R.MCKENNA,D.N.SILVERMANTITL STRUCTURAL AND KINETIC ANALYSIS OF PROTON SHUTTLE RESIDUESTITL 2 IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE III.REF PROTEINS V. 68 337 2007REFN ISSN 0887-3585PMID 17427958DOI 10.1002/PROT.21403 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4bqd TFPI kd1 of human tfpi in complex with a synthetic peptide 2.45Å AUTH M.DOCKAL,R.HARTMAN,M.FRIES,M.CHRISTELLA,L.G.D.THOMASSEN,AUTH 2 A.HEIZMAN,H.EHRLICH,J.ROSING,F.OSTERKAMP,T.POLAKOWSKI,AUTH 3 U.REINEKE,A.GRIESSNER,H.BRANDSTETTER,F.SCHEIFLINGERTITL SMALL PEPTIDES BLOCKING INHIBITION OF FACTOR XA AND TISSUETITL 2 FACTOR-FACTOR VIIA BY TISSUE FACTOR PATHWAY INHIBITORTITL 3 (TFPI)REF J.BIOL.CHEM. V. 289 1732 2014REFN ISSN 0021-9258PMID 24275667DOI 10.1074/JBC.M113.533836 Variant Set Distributions Mapped Variants
General Structure Information 1m9i ANXA6 crystal structure of phosphorylation-mimicking mutant t356d of annexin vi 2.65Å AUTH C.FREYE-MINKS,R.H.KRETSINGER,C.E.CREUTZTITL STRUCTURAL AND DYNAMIC CHANGES IN HUMAN ANNEXIN VITITL 2 INDUCED BY A PHOSPHORYLATION-MIMICKING MUTATION,TITL 3 T356DREF BIOCHEMISTRY V. 42 620 2003REFN ISSN 0006-2960PMID 12534274DOI 10.1021/BI026742H Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4adf CSF1 crystal structure of the human colony-stimulating factor 1 (hcsf-1) cytokine in complex with the viral receptor barf1 4.4Å AUTH J.ELEGHEERT,N.BRACKE,P.POULIOT,I.GUTSCHE,A.V.SHKUMATOV,AUTH 2 N.TARBOURIECH,K.VERSTRAETE,A.BEKAERT,W.P.BURMEISTER,AUTH 3 D.I.SVERGUN,B.N.LAMBRECHT,B.VERGAUWEN,S.N.SAVVIDESTITL ALLOSTERIC COMPETITIVE INACTIVATION OF HEMATOPOIETIC CSF-1TITL 2 SIGNALING BY THE VIRAL DECOY RECEPTOR BARF1.REF NAT.STRUCT.MOL.BIOL. V. 19 938 2012REFN ISSN 1545-9993PMID 22902366DOI 10.1038/NSMB.2367 Variant Set Distributions […]
General Structure Information 1i71 LPA high resolution crystal structure of apolipoprotein(a) kringle iv type 7: insights into ligand binding 1.45Å AUTH Q.YE,M.N.RAHMAN,M.L.KOSCHINSKY,Z.JIATITL HIGH-RESOLUTION CRYSTAL STRUCTURE OFTITL 2 APOLIPOPROTEIN(A) KRINGLE IV TYPE 7: INSIGHTS INTOTITL 3 LIGAND BINDING.REF PROTEIN SCI. V. 10 1124 2001REFN ISSN 0961-8368PMID 11369850DOI 10.1110/PS.01701 Variant Set Distributions Mapped Variants