Assessment of Structural Intolerance and Durability
General Structure Information 1z6u UHRF2 np95-like ring finger protein isoform b [homo sapiens] 2.1Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,E.M.NEWMAN,AUTH 2 F.MACKENZIE,M.SUNDSTROM,C.ARROWSMITH,A.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANON,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL 2.1 ANGSTROM CRYSTAL STRUCTURE OF THE HUMANTITL 2 UBIQUITIN LIAGSE NIRFREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3elb PCYT2 human ctp: phosphoethanolamine cytidylyltransferase in complex with cmp 2.0Å AUTH T.KARLBERG,M.WELIN,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WIKSTROM,M.WISNIEWSKA,H.SCHULERTITL HUMAN CTP:PHOSPHOETHANOLAMINE CYTIDYLYLTRANSFERASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2iuw ALKBH3 crystal structure of human abh3 in complex with iron ion and 2-oxoglutarate 1.5Å AUTH O.SUNDHEIM,C.B.VAGBO,M.BJORAS,M.M.L.DESOUSA,AUTH 2 V.TALSTAD,P.A.AAS,F.DRABLOS,H.E.KROKAN,J.A.TAINER,AUTH 3 G.SLUPPHAUGTITL HUMAN ABH3 STRUCTURE AND KEY RESIDUES FORTITL 2 OXIDATIVE DEMETHYLATION TO REVERSE DNA/RNA DAMAGE.REF EMBO J. V. 25 3389 2006REFN ISSN 0261-4189PMID 16858410DOI 10.1038/SJ.EMBOJ.7601219 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3l6b SRR x-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor 1.5Å AUTH M.A.SMITH,V.MACK,A.EBNETH,I.MORAES,B.FELICETTI,M.WOOD,AUTH 2 D.SCHONFELD,O.MATHER,A.CESURA,J.BARKERTITL THE STRUCTURE OF MAMMALIAN SERINE RACEMASE: EVIDENCE FORTITL 2 CONFORMATIONAL CHANGES UPON INHIBITOR BINDING.REF J.BIOL.CHEM. V. 285 12873 2010REFN ISSN 0021-9258PMID 20106978DOI 10.1074/JBC.M109.050062 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2lb2 NEDD4L structure of the second domain of human nedd4l in complex with a phosphorylated ptpy motif derived from human smad3 -1.0Å AUTH E.ARAGON,N.GOERNER,A.I.ZAROMYTIDOU,Q.XI,A.ESCOBEDO,AUTH 2 J.MASSAGUE,M.J.MACIASTITL A SMAD ACTION TURNOVER SWITCH OPERATED BY WW DOMAIN READERSTITL 2 OF A PHOSPHOSERINE CODE.REF GENES DEV. V. 25 1275 2011REFN ISSN 0890-9369PMID 21685363DOI 10.1101/GAD.2060811 Variant […]
General Structure Information 2x4d LHPP crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase lhpp 1.92Å AUTH M.VOLLMAR,C.GILEADI,K.GUO,P.SAVITSKY,J.R.C.MUNIZ,W.YUE,AUTH 2 C.ALLERSTON,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN PHOSPHOLYSINE PHOSPHOHISTIDINETITL 2 INORGANIC PYROPHOSPHATE PHOSPHATASE LHPPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dlq IL22 crystal structure of the il-22/il-22r1 complex 1.9Å AUTH L.BLEICHER,P.R.DE MOURA,L.WATANABE,D.COLAU,AUTH 2 L.DUMOUTIER,J.-C.RENAULD,I.POLIKARPOVTITL CRYSTAL STRUCTURE OF THE IL-22/IL-22R1 COMPLEX ANDTITL 2 ITS IMPLICATIONS FOR THE IL-22 SIGNALING MECHANISMREF FEBS LETT. V. 582 2985 2008REFN ISSN 0014-5793PMID 18675809DOI 10.1016/J.FEBSLET.2008.07.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3voq MAPKAP1 crystal structure of the pleckstrin homology domain of human sin1, a torc2 subunit 2.0Å AUTH D.PAN,Y.MATSUURATITL STRUCTURES OF THE PLECKSTRIN HOMOLOGY DOMAIN OFTITL 2 SACCHAROMYCES CEREVISIAE AVO1 AND ITS HUMAN ORTHOLOGUE SIN1,TITL 3 AN ESSENTIAL SUBUNIT OF TOR COMPLEX 2REF ACTA CRYSTALLOGR.,SECT.F V. 68 386 2012REFN ESSN 1744-3091PMID 22505404DOI 10.1107/S1744309112007178 […]
General Structure Information 3obq TSG101 crystal structure of the tsg101 uev domain in complex with a human hrs psap peptide 1.4Å AUTH Y.J.IM,L.KUO,X.REN,P.V.BURGOS,X.Z.ZHAO,F.LIU,T.R.BURKE,AUTH 2 J.S.BONIFACINO,E.O.FREED,J.H.HURLEYTITL CRYSTALLOGRAPHIC AND FUNCTIONAL ANALYSIS OF THE ESCRT-ITITL 2 /HIV-1 GAG PTAP INTERACTION.REF STRUCTURE V. 18 1536 2010REFN ISSN 0969-2126PMID 21070952DOI 10.1016/J.STR.2010.08.010 Variant Set Distributions Mapped Variants
General Structure Information 1jpy IL17F crystal structure of il-17f 2.85Å AUTH S.G.HYMOWITZ,E.H.FILVAROFF,J.P.YIN,J.LEE,L.CAI,P.RISSER,AUTH 2 M.MARUOKA,W.MAO,J.FOSTER,R.F.KELLEY,G.PAN,A.L.GURNEY,AUTH 3 A.M.DE VOS,M.A.STAROVASNIKTITL IL-17S ADOPT A CYSTINE KNOT FOLD: STRUCTURE AND ACTIVITY OFTITL 2 A NOVEL CYTOKINE, IL-17F, AND IMPLICATIONS FOR RECEPTORTITL 3 BINDING.REF EMBO J. V. 20 5332 2001REFN ISSN 0261-4189PMID 11574464DOI 10.1093/EMBOJ/20.19.5332 Variant Set Distributions Ripley’s K Analysis Plots […]