Assessment of Structural Intolerance and Durability
General Structure Information 2psx KLK5 crystal structure of human kallikrein 5 in complex with leupeptin 2.3Å AUTH M.DEBELA,P.GOETTIG,V.MAGDOLEN,R.HUBER,N.M.SCHECHTER,W.BODETITL STRUCTURAL BASIS OF THE ZINC INHIBITION OF HUMAN TISSUETITL 2 KALLIKREIN 5.REF J.MOL.BIOL. V. 373 1017 2007REFN ISSN 0022-2836PMID 17881000DOI 10.1016/J.JMB.2007.08.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3otf HCN4 structural basis for the camp-dependent gating in human hcn4 channel 2.4Å AUTH X.XU,Z.V.VYSOTSKAYA,Q.LIU,L.ZHOUTITL STRUCTURAL BASIS FOR THE CAMP-DEPENDENT GATING IN THE HUMANTITL 2 HCN4 CHANNEL.REF J.BIOL.CHEM. V. 285 37082 2010REFN ISSN 0021-9258PMID 20829353DOI 10.1074/JBC.M110.152033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4e9m NOD1 nod1 card domain with three disulfide-clinched, domain-swapped dimers in the asymmetric unit 2.15Å AUTH E.A.BERRY,L.S.HUANG,N.WALKER-KOPPTITL CRYSTAL STRUCTURE OF NOD1 CARD DOMAIN WITH THREETITL 2 DISULFIDE-CLINCHED, DOMAIN-SWAPPED DIMERS IN THE ASYMMETRICTITL 3 UNITREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1g2t CCL26 solution structure of eotaxin-3 -1.0Å AUTH J.YE,K.L.MAYER,M.R.MAYER,M.J.STONETITL NMR SOLUTION STRUCTURE AND BACKBONE DYNAMICS OFTITL 2 THE CC CHEMOKINE EOTAXIN-3.REF BIOCHEMISTRY V. 40 7820 2001REFN ISSN 0006-2960PMID 11425309DOI 10.1021/BI010252S Variant Set Distributions Mapped Variants
General Structure Information 3llr DNMT3A crystal structure of the pwwp domain of human dna (cytosine-5-)- methyltransferase 3 alpha 2.3Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2ygq WIF1 wif domain-epidermal growth factor (egf)-like domains 1-3 of human wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine 3.95Å AUTH T.MALINAUSKAS,A.R.ARICESCU,W.LU,C.SIEBOLD,E.Y.JONESTITL MODULAR MECHANISM OF WNT SIGNALING INHIBITION BY WNTTITL 2 INHIBITORY FACTOR 1REF NAT.STRUCT.MOL.BIOL. V. 18 886 2011REFN ISSN 1545-9993PMID 21743455DOI 10.1038/NSMB.2081 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2ns2 SPIN1 crystal structure of spindlin1 2.2Å AUTH Q.ZHAO,L.QIN,F.JIANG,B.WU,W.YUE,F.XU,Z.RONG,H.YUAN,AUTH 2 X.XIE,Y.GAO,C.BAI,M.BARTLAM,X.PEI,Z.RAOTITL STRUCTURE OF HUMAN SPINDLIN1. TANDEM TUDOR-LIKETITL 2 DOMAINS FOR CELL CYCLE REGULATIONREF J.BIOL.CHEM. V. 282 647 2007REFN ISSN 0021-9258PMID 17082182DOI 10.1074/JBC.M604029200 Variant Set Distributions Mapped Variants
General Structure Information 1wyo MAPRE3 solution structure of the ch domain of human microtubule- associated protein rp/eb family member 3 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN OF HUMANTITL 2 MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBERTITL 3 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kum CCL27 solution structure of the human chemokine ccl27 -1.0Å AUTH A.L.JANSMA,J.P.KIRKPATRICK,A.R.HSU,T.M.HANDEL,D.NIETLISPACHTITL NMR ANALYSIS OF THE STRUCTURE, DYNAMICS, AND UNIQUETITL 2 OLIGOMERIZATION PROPERTIES OF THE CHEMOKINE CCL27.REF J.BIOL.CHEM. V. 285 14424 2010REFN ISSN 0021-9258PMID 20200157DOI 10.1074/JBC.M109.091108 Variant Set Distributions Mapped Variants
General Structure Information 3a1b DNMT3A crystal structure of the dnmt3a add domain in complex with histone h3 2.29Å AUTH J.OTANI,T.NANKUMO,K.ARITA,S.INAMOTO,M.ARIYOSHI,M.SHIRAKAWATITL STRUCTURAL BASIS FOR RECOGNITION OF H3K4 METHYLATION STATUSTITL 2 BY THE DNA METHYLTRANSFERASE 3A ATRX-DNMT3-DNMT3L DOMAINREF EMBO REP. V. 10 1235 2009REFN ISSN 1469-221XPMID 19834512DOI 10.1038/EMBOR.2009.218 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]