Assessment of Structural Intolerance and Durability
General Structure Information 2eho GINS2 crystal structure of human gins complex 3.0Å AUTH J.M.CHOI,H.S.LIM,J.J.KIM,O.K.SONG,Y.CHOTITL CRYSTAL STRUCTURE OF THE HUMAN GINS COMPLEXREF GENES DEV. V. 21 1316 2007REFN ISSN 0890-9369PMID 17545466DOI 10.1101/GAD.1548107 Variant Set Distributions Mapped Variants
General Structure Information 2bwj AK5 structure of adenylate kinase 5 2.3Å AUTH P.FILIPPAKOPOULOS,G.BUNKOCZI,A.JANSSON,E.LONGMAN,S.KNAPPTITL STRUCTURE OF ADENYLATE KINASE 5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4a1n EXOG human mitochondrial endo-exonuclease 2.8Å AUTH M.WELIN,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,S.GRASLUND,M.HAMMARSTROM,AUTH 3 I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,T.NYMAN,C.PERSSON,AUTH 4 H.SCHULER,A.G.THORSELL,L.TRESAUGUES,J.WEIGELT,P.NORDLUNDTITL HUMAN MITOCHONDRIAL ENDO-EXONUCLEASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2k1v INSL5 r3/i5 relaxin chimera -1.0Å AUTH L.M.HAUGAARD-JONSSON,M.A.HOSSAIN,N.L.DALY,AUTH 2 R.A.BATHGATE,J.D.WADE,D.J.CRAIK,K.J.ROSENGRENTITL STRUCTURE OF THE R3/I5 CHIMERIC RELAXIN PEPTIDE, ATITL 2 SELECTIVE GPCR135 AND GPCR142 AGONIST.REF J.BIOL.CHEM. V. 283 23811 2008REFN ISSN 0021-9258PMID 18577524DOI 10.1074/JBC.M800489200 Variant Set Distributions Mapped Variants
General Structure Information 2lop TMEM14A backbone structure of human membrane protein tmem14a -1.0Å AUTH C.KLAMMT,I.MASLENNIKOV,M.BAYRHUBER,C.EICHMANN,N.VAJPAI,AUTH 2 E.J.CHIU,K.Y.BLAIN,L.ESQUIVIES,J.H.KWON,B.BALANA,U.PIEPER,AUTH 3 A.SALI,P.A.SLESINGER,W.KWIATKOWSKI,R.RIEK,S.CHOETITL FACILE BACKBONE STRUCTURE DETERMINATION OF HUMAN MEMBRANETITL 2 PROTEINS BY NMR SPECTROSCOPY.REF NAT.METHODS V. 9 834 2012REFN ISSN 1548-7091PMID 22609626DOI 10.1038/NMETH.2033 Variant Set Distributions Mapped Variants
General Structure Information 2l9n SBDS structure of the human shwachman-bodian-diamond syndrome (sbds) protein -1.0Å AUTH A.J.FINCH,C.HILCENKO,N.BASSE,L.F.DRYNAN,B.GOYENECHEA,AUTH 2 T.F.MENNE,A.GONZALEZ FERNANDEZ,P.SIMPSON,C.S.DSANTOS,AUTH 3 M.J.ARENDS,J.DONADIEU,C.BELLANNE-CHANTELOT,M.COSTANZO,AUTH 4 C.BOONE,A.N.MCKENZIE,S.M.FREUND,A.J.WARRENTITL UNCOUPLING OF GTP HYDROLYSIS FROM EIF6 RELEASE ON THETITL 2 RIBOSOME CAUSES SHWACHMAN-DIAMOND SYNDROME.REF GENES DEV. V. 25 917 2011REFN ISSN 0890-9369PMID 21536732DOI 10.1101/GAD.623011 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ebk RWDD3 solution structure of the rwd domain of human rwd domain containing protein 3 -1.0Å AUTH M.YONEYAMA,S.KOSHIBA,S.WATABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RWD DOMAIN OF HUMAN RWDTITL 2 DOMAIN CONTAINING PROTEIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1y2o BAIAP2 structure of n-terminal domain irsp53/baiap2 2.2Å AUTH T.H.MILLARD,G.BOMPARD,M.-Y.HEUNG,T.R.DAFFORN,AUTH 2 D.J.SCOTT,L.M.MACHESKY,K.FUTTERERTITL STRUCTURAL BASIS OF FILOPODIA FORMATION INDUCED BYTITL 2 THE IRSP53/MIM HOMOLOGY DOMAIN OF HUMAN IRSP53REF EMBO J. V. 24 240 2005REFN ISSN 0261-4189PMID 15635447DOI 10.1038/SJ.EMBOJ.7600535 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z0d ATG4B the crystal structure of human atg4b- lc3(1-120) complex 1.9Å AUTH K.SATOO,N.N.NODA,H.KUMETA,Y.FUJIOKA,N.MIZUSHIMA,AUTH 2 Y.OHSUMI,F.INAGAKITITL THE STRUCTURE OF ATG4B-LC3 COMPLEX REVEALS THETITL 2 MECHANISM OF LC3 PROCESSING AND DELIPIDATION DURINGTITL 3 AUTOPHAGY.REF EMBO J. V. 28 1341 2009REFN ISSN 0261-4189PMID 19322194DOI 10.1038/EMBOJ.2009.80 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4lqy ENPP4 crystal structure of human enpp4 with amp 1.54Å AUTH R.A.ALBRIGHT,D.L.ORNSTEIN,W.CAO,W.C.CHANG,D.ROBERT,M.TEHAN,AUTH 2 D.HOYER,L.LIU,P.STABACH,G.YANG,E.M.DE LA CRUZ,D.T.BRADDOCKTITL MOLECULAR BASIS OF PURINERGIC SIGNAL METABOLISM BYTITL 2 ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASES 4 AND 1TITL 3 AND IMPLICATIONS IN STROKE.REF J.BIOL.CHEM. V. 289 3294 2014REFN ISSN 0021-9258PMID 24338010DOI 10.1074/JBC.M113.505867 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]