General Structure Information
| PDB ID | 3otf |
| HGNC Gene Label(s) | HCN4 |
| Structure Name | structural basis for the camp-dependent gating in human hcn4 channel |
| Resolution | 2.4Å |
| Reference | AUTH X.XU,Z.V.VYSOTSKAYA,Q.LIU,L.ZHOUTITL STRUCTURAL BASIS FOR THE CAMP-DEPENDENT GATING IN THE HUMANTITL 2 HCN4 CHANNEL.REF J.BIOL.CHEM. V. 285 37082 2010REFN ISSN 0021-9258PMID 20829353DOI 10.1074/JBC.M110.152033 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 197 |
| Number Of SNVs | 46 |
| Number Of Permutations | 18230 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.14 |
| p-value | 0.074 |
COSMIC
| Number Of Residues | 197 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.333 |
| p-value | 0.94 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 46 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | -0.483 |
| p-value | 0.247 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
