General Structure Information
| PDB ID | 3llr |
| HGNC Gene Label(s) | DNMT3A |
| Structure Name | crystal structure of the pwwp domain of human dna (cytosine-5-)- methyltransferase 3 alpha |
| Resolution | 2.3Å |
| Reference | AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 131 |
| Number Of SNVs | 18 |
| Number Of Permutations | 1774 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.353 |
| p-value | 0.542 |
COSMIC
| Number Of Residues | 131 |
| Number Of SNVs | 3 |
| Number Of Permutations | 27 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.333 |
| p-value | 0.54 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 18 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.588 |
| p-value | 0.25 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
