Assessment of Structural Intolerance and Durability
General Structure Information 3qe9 EXO1 crystal structure of human exonuclease 1 exo1 (d173a) in complex with dna (complex i) 2.51Å AUTH J.ORANS,E.A.MCSWEENEY,R.R.IYER,M.A.HAST,H.W.HELLINGA,AUTH 2 P.MODRICH,L.S.BEESETITL STRUCTURES OF HUMAN EXONUCLEASE 1 DNA COMPLEXES SUGGEST ATITL 2 UNIFIED MECHANISM FOR NUCLEASE FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 145 212 2011REFN ISSN 0092-8674PMID 21496642DOI 10.1016/J.CELL.2011.03.005 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4i5l PPP2R3B structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation 2.43Å AUTH N.WLODARCHAK,F.GUO,K.A.SATYSHUR,L.JIANG,P.D.JEFFREY,T.SUN,AUTH 2 V.STANEVICH,M.C.MUMBY,Y.XINGTITL STRUCTURE OF THE CA(2+)-DEPENDENT PP2A HETEROTRIMER ANDTITL 2 INSIGHTS INTO CDC6 DEPHOSPHORYLATION.REF CELL RES. V. 23 931 2013REFN ISSN 1001-0602PMID 23752926DOI 10.1038/CR.2013.77 Variant Set Distributions Mapped Variants
General Structure Information 2ouc DUSP10 crystal structure of the map kinase binding domain of mkp5 2.2Å AUTH X.TAO,L.TONGTITL CRYSTAL STRUCTURE OF THE MAP KINASE BINDING DOMAINTITL 2 AND THE CATALYTIC DOMAIN OF HUMAN MKP5.REF PROTEIN SCI. V. 16 880 2007REFN ISSN 0961-8368PMID 17400920DOI 10.1110/PS.062712807 Variant Set Distributions Mapped Variants
General Structure Information 3hcs TRAF6 crystal structure of the n-terminal domain of traf6 2.2Å AUTH Q.YIN,S.C.LIN,B.LAMOTHE,M.LU,Y.C.LO,G.HURA,L.ZHENG,AUTH 2 R.L.RICH,A.D.CAMPOS,D.G.MYSZKA,M.J.LENARDO,AUTH 3 B.G.DARNAY,H.WUTITL E2 INTERACTION AND DIMERIZATION IN THE CRYSTALTITL 2 STRUCTURE OF TRAF6.REF NAT.STRUCT.MOL.BIOL. V. 16 658 2009REFN ISSN 1545-9993PMID 19465916DOI 10.1038/NSMB.1605 Variant Set Distributions Mapped Variants
General Structure Information 2q8k PA2G4 the crystal structure of ebp1 1.6Å AUTH E.KOWALINSKI,G.BANGE,B.BRADATSCH,E.HURT,K.WILD,I.SINNINGTITL THE CRYSTAL STRUCTURE OF EBP1 REVEALS A METHIONINETITL 2 AMINOPEPTIDASE FOLD AS BINDING PLATFORM FOR MULTIPLETITL 3 INTERACTIONS.REF FEBS LETT. V. 581 4450 2007REFN ISSN 0014-5793PMID 17765895DOI 10.1016/J.FEBSLET.2007.08.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3soa CAMK2A full-length human camkii 3.55Å AUTH L.H.CHAO,M.M.STRATTON,I.H.LEE,O.S.ROSENBERG,J.LEVITZ,AUTH 2 D.J.MANDELL,T.KORTEMME,J.T.GROVES,H.SCHULMAN,J.KURIYANTITL A MECHANISM FOR TUNABLE AUTOINHIBITION IN THE STRUCTURE OF ATITL 2 HUMAN CA(2+)/CALMODULIN- DEPENDENT KINASE II HOLOENZYME.REF CELL(CAMBRIDGE,MASS.) V. 146 732 2011REFN ISSN 0092-8674PMID 21884935DOI 10.1016/J.CELL.2011.07.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2h16 ARL5A structure of human adp-ribosylation factor-like 5 (arl5) 2.0Å AUTH W.M.RABEH,W.TEMPEL,D.YANIW,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 5TITL 2 (ARL5)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gtr CDYL human chromodomain y-like protein 1.9Å AUTH T.ANTOSHENKO,J.MIN,H.WU,P.LOPPNAU,J.WEIGELT,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN CHROMODOMAIN Y-LIKETITL 2 PROTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4g8a LY96 crystal structure of human tlr4 polymorphic variant d299g and t399i in complex with md-2 and lps 2.4Å AUTH U.OHTO,N.YAMAKAWA,S.AKASHI-TAKAMURA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL ANALYSES OF HUMAN TOLL-LIKE RECEPTOR 4TITL 2 POLYMORPHISMS D299G AND T399IREF J.BIOL.CHEM. V. 287 40611 2012REFN ISSN 0021-9258PMID 23055527DOI 10.1074/JBC.M112.404608 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3f3s CRYL1 the crystal structure of human lambda-crystallin, cryl1 2.0Å AUTH E.UGOCHUKWU,C.JOHANSSON,W.W.YUE,G.KOCHAN,E.PILKA,A.KRAMM,AUTH 2 A.C.W.PIKE,P.FILIPPAKOPOULOS,F.VON DELFT,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN LAMBDA-CRYSTALLIN, CRYL1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants