Assessment of Structural Intolerance and Durability
General Structure Information 1unh CDK5R1 structural mechanism for the inhibition of cdk5-p25 by roscovitine, aloisine and indirubin. 2.35Å AUTH M.MAPELLI,L.MASSIMILINAO,C.CROVACE,M.A.SEELIGER,L.-H.TSAI,AUTH 2 L.MEIJER,A.MUSACCHIOTITL MECHANISM OF CDK5/P25 BINDING BY CDK INHIBITORSREF J.MED.CHEM. V. 48 671 2005REFN ISSN 0022-2623PMID 15689152DOI 10.1021/JM049323M Variant Set Distributions Mapped Variants
General Structure Information 1zsg ARHGEF7 beta pix-sh3 complexed with an atypical peptide from alpha- pak -1.0Å AUTH H.R.MOTT,D.NIETLISPACH,K.A.EVETTS,D.OWENTITL STRUCTURAL ANALYSIS OF THE SH3 DOMAIN OF BETA-PIXTITL 2 AND ITS INTERACTION WITH ALPHA-P21 ACTIVATEDTITL 3 KINASE (PAK)REF BIOCHEMISTRY V. 44 10977 2005REFN ISSN 0006-2960PMID 16101281DOI 10.1021/BI050374A Variant Set Distributions Mapped Variants
General Structure Information 2l5u CHD4 structure of the first phd finger (phd1) from chd4 (mi2b) -1.0Å AUTH R.E.MANSFIELD,C.A.MUSSELMAN,A.H.KWAN,S.S.OLIVER,A.L.GARSKE,AUTH 2 F.DAVRAZOU,J.M.DENU,T.G.KUTATELADZE,J.P.MACKAYTITL PLANT HOMEODOMAIN (PHD) FINGERS OF CHD4 ARE HISTONETITL 2 H3-BINDING MODULES WITH PREFERENCE FOR UNMODIFIED H3K4 ANDTITL 3 METHYLATED H3K9REF J.BIOL.CHEM. V. 286 11779 2011REFN ISSN 0021-9258PMID 21278251DOI 10.1074/JBC.M110.208207 Variant Set Distributions Mapped Variants
General Structure Information 1x0f HNRNPD complex structure of the c-terminal rna-binding domain of hnrnp d(auf1) with telomeric dna -1.0Å AUTH Y.ENOKIZONO,Y.KONISHI,K.NAGATA,K.OUHASHI,S.UESUGI,AUTH 2 F.ISHIKAWA,M.KATAHIRATITL STRUCTURE OF HNRNP D COMPLEXED WITHTITL 2 SINGLE-STRANDED TELOMERE DNA AND UNFOLDING OF THETITL 3 QUADRUPLEX BY HETEROGENEOUS NUCLEARTITL 4 RIBONUCLEOPROTEIN D.REF J.BIOL.CHEM. V. 280 18862 2005REFN ISSN 0021-9258PMID 15734733DOI 10.1074/JBC.M411822200 Variant […]
General Structure Information 3sea RHEB structure of rheb-y35a mutant in gdp- and gmppnp-bound forms 2.0Å AUTH M.T.MAZHAB-JAFARI,C.B.MARSHALL,N.ISHIYAMA,J.HO,V.DI PALMA,AUTH 2 V.STAMBOLIC,M.IKURATITL AN AUTOINHIBITED NONCANONICAL MECHANISM OF GTP HYDROLYSIS BYTITL 2 RHEB MAINTAINS MTORC1 HOMEOSTASIS.REF STRUCTURE V. 20 1528 2012REFN ISSN 0969-2126PMID 22819219DOI 10.1016/J.STR.2012.06.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2qlu ACVR2B crystal structure of activin receptor type ii kinase domain from human 2.0Å AUTH S.HAN,P.LOULAKIS,M.GRIFFOR,Z.XIETITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE IIBTITL 2 KINASE DOMAIN FROM HUMAN AT 2.0 ANGSTROM RESOLUTIONREF PROTEIN SCI. V. 16 2272 2007REFN ISSN 0961-8368PMID 17893364DOI 10.1110/PS.073068407 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2d8z FHL2 solution structure of the third lim domain of four and a half lim domains protein 2 (fhl-2) -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD LIM DOMAIN OF FOURTITL 2 AND A HALF LIM DOMAINS PROTEIN 2 (FHL-2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jbm QPRT qprtase structure from human 2.0Å AUTH H.LIU,K.WOZNICA,G.CATTON,A.CRAWFORD,N.BOTTINF,AUTH 2 J.H.NAISMITHTITL STRUCTURAL AND KINETIC CHARACTERIZATION OFTITL 2 QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (HQPRTASE)TITL 3 FROM HOMO SAPIENS.REF J.MOL.BIOL. V. 373 755 2007REFN ISSN 0022-2836PMID 17868694DOI 10.1016/J.JMB.2007.08.043 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4erv RYR3 crystal structure of human ryanodine receptor 3 (2597-2800) 1.75Å AUTH Z.YUCHI,K.LAU,F.VAN PETEGEMTITL DISEASE MUTATIONS IN THE RYANODINE RECEPTOR CENTRAL REGION:TITL 2 CRYSTAL STRUCTURES OF A PHOSPHORYLATION HOT SPOT DOMAIN.REF STRUCTURE V. 20 1201 2012REFN ISSN 0969-2126PMID 22705209DOI 10.1016/J.STR.2012.04.015 Variant Set Distributions Mapped Variants
General Structure Information 3l4c DOCK1 structural basis of membrane-targeting by dock180 2.37Å AUTH L.PREMKUMAR,A.A.BOBKOV,M.PATEL,L.JAROSZEWSKI,L.A.BANKSTON,AUTH 2 B.STEC,K.VUORI,J.F.COTE,R.C.LIDDINGTONTITL STRUCTURAL BASIS OF MEMBRANE TARGETING BY THE DOCK180TITL 2 FAMILY OF RHO FAMILY GUANINE EXCHANGE FACTORS (RHO-GEFS).REF J.BIOL.CHEM. V. 285 13211 2010REFN ISSN 0021-9258PMID 20167601DOI 10.1074/JBC.M110.102517 Variant Set Distributions Mapped Variants