Assessment of Structural Intolerance and Durability
General Structure Information 3bua TERF2 crystal structure of trf2 trfh domain and apollo peptide complex 2.5Å AUTH Y.CHEN,Y.YANG,M.VAN OVERBEEK,J.R.DONIGIAN,P.BACIU,AUTH 2 T.DE LANGE,M.LEITITL A SHARED DOCKING MOTIF IN TRF1 AND TRF2 USED FORTITL 2 DIFFERENTIAL RECRUITMENT OF TELOMERIC PROTEINS.REF SCIENCE V. 319 1092 2008REFN ISSN 0036-8075PMID 18202258DOI 10.1126/SCIENCE.1151804 Variant Set Distributions Mapped Variants
General Structure Information 2mbg RALBP1 rlip76 (gap-gbd) -1.0Å AUTH K.V.RAJASEKAR,L.J.CAMPBELL,D.NIETLISPACH,D.OWEN,H.R.MOTTTITL THE STRUCTURE OF THE RLIP76 RHOGAP-RAL BINDING DOMAIN DYAD:TITL 2 FIXED POSITION OF THE DOMAINS LEADS TO DUAL ENGAGEMENT OFTITL 3 SMALL G PROTEINS AT THE MEMBRANE.REF STRUCTURE V. 21 2131 2013REFN ISSN 0969-2126PMID 24207123DOI 10.1016/J.STR.2013.09.007 Variant Set Distributions Mapped Variants
General Structure Information 4mq2 DYRK1A the crystal structure of dyrk1a with a bound pyrido[2,3-d]pyrimidine inhibitor 2.8Å AUTH K.ANDERSON,Y.CHEN,Z.CHEN,R.DOMINIQUE,K.GLENN,Y.HE,C.JANSON,AUTH 2 K.C.LUK,C.LUKACS,A.POLONSKAIA,Q.QIAO,A.RAILKAR,P.ROSSMAN,AUTH 3 H.SUN,Q.XIANG,M.VILENCHIK,P.WOVKULICH,X.ZHANGTITL PYRIDO[2,3-D]PYRIMIDINES: DISCOVERY AND PRELIMINARY SAR OF ATITL 2 NOVEL SERIES OF DYRK1B AND DYRK1A INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 6610 2013REFN ISSN 0960-894XPMID 24239188DOI 10.1016/J.BMCL.2013.10.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1s1c ROCK1 crystal structure of the complex between the human rhoa and rho-binding domain of human rocki 2.6Å AUTH R.DVORSKY,L.BLUMENSTEIN,I.R.VETTER,M.R.AHMADIANTITL STRUCTURAL INSIGHTS INTO THE INTERACTION OF ROCKITITL 2 WITH THE SWITCH REGIONS OF RHOA.REF J.BIOL.CHEM. V. 279 7098 2004REFN ISSN 0021-9258PMID 14660612DOI 10.1074/JBC.M311911200 Variant Set Distributions Mapped Variants
General Structure Information 2mf9 FKBP8 solution structure of the n-terminal domain of human fkbp38 (fkbp38ntd) -1.0Å AUTH C.KANG,H.YE,J.CHIA,B.H.CHOI,S.DHE-PAGANON,B.SIMON,U.SCHUTZ,AUTH 2 M.SATTLER,H.S.YOONTITL FUNCTIONAL ROLE OF THE FLEXIBLE N-TERMINAL EXTENSION OFTITL 2 FKBP38 IN CATALYSIS.REF SCI REP V. 3 2985 2013REFN ESSN 2045-2322PMID 24145868DOI 10.1038/SREP02985 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2eho GINS1 crystal structure of human gins complex 3.0Å AUTH J.M.CHOI,H.S.LIM,J.J.KIM,O.K.SONG,Y.CHOTITL CRYSTAL STRUCTURE OF THE HUMAN GINS COMPLEXREF GENES DEV. V. 21 1316 2007REFN ISSN 0890-9369PMID 17545466DOI 10.1101/GAD.1548107 Variant Set Distributions Mapped Variants
General Structure Information 1cb5 BLMH human bleomycin hydrolase. 2.59Å AUTH P.A.OFARRELL,F.GONZALEZ,W.ZHENG,S.A.JOHNSTON,L.JOSHUA-TORTITL CRYSTAL STRUCTURE OF HUMAN BLEOMYCIN HYDROLASE, ATITL 2 SELF-COMPARTMENTALIZING CYSTEINE PROTEASE.REF STRUCTURE FOLD.DES. V. 7 619 1999REFN ISSN 0969-2126PMID 10404591DOI 10.1016/S0969-2126(99)80083-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ogj PRKG1 crystal structure of partial apo (92-227) of cgmp-dependent protein kinase 2.75Å AUTH J.J.KIM,D.E.CASTEEL,G.HUANG,T.H.KWON,R.K.REN,P.ZWART,AUTH 2 J.J.HEADD,N.G.BROWN,D.C.CHOW,T.PALZKILL,C.KIMTITL CO-CRYSTAL STRUCTURES OF PKG IBETA (92-227) WITH CGMP ANDTITL 2 CAMP REVEAL THE MOLECULAR DETAILS OF CYCLIC-NUCLEOTIDETITL 3 BINDINGREF PLOS ONE V. 6 E1841 2011REFN ESSN 1932-6203PMID 21526164DOI 10.1371/JOURNAL.PONE.0018413 Variant Set Distributions Mapped Variants
General Structure Information 3g4h RGN crystal structure of human senescence marker protein-30 (zinc bound) 1.92Å AUTH S.CHAKRABORTI,B.J.BAHNSONTITL CRYSTAL STRUCTURE OF HUMAN SENESCENCE MARKER PROTEIN 30:TITL 2 INSIGHTS LINKING STRUCTURAL, ENZYMATIC, AND PHYSIOLOGICALTITL 3 FUNCTIONS .REF BIOCHEMISTRY V. 49 3436 2010REFN ISSN 0006-2960PMID 20329768DOI 10.1021/BI9022297 Variant Set Distributions Mapped Variants
General Structure Information 3m1n SHH crystal structure of human sonic hedgehog n-terminal domain 1.85Å AUTH R.B.PEPINSKY,P.RAYHORN,E.S.DAY,A.DERGAY,AUTH 2 K.P.WILLIAMS,A.GALDES,F.R.TAYLOR,AUTH 3 P.A.BORIACK-SJODIN,E.A.GARBERTITL MAPPING SONIC HEDGEHOG-RECEPTOR INTERACTIONS BYTITL 2 STERIC INTERFERENCE.REF J.BIOL.CHEM. V. 275 10995 2000REFN ISSN 0021-9258PMID 10753901DOI 10.1074/JBC.275.15.10995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants