Assessment of Structural Intolerance and Durability
General Structure Information 3eu9 ZDHHC17 the ankyrin repeat domain of huntingtin interacting protein 14 1.99Å AUTH T.GAO,R.E.COLLINS,J.R.HORTON,X.ZHANG,R.ZHANG,A.DHAYALAN,AUTH 2 R.TAMAS,A.JELTSCH,X.CHENGTITL THE ANKYRIN REPEAT DOMAIN OF HUNTINGTIN INTERACTING PROTEINTITL 2 14 CONTAINS A SURFACE AROMATIC CAGE, A POTENTIAL SITE FORTITL 3 METHYL-LYSINE BINDING.REF PROTEINS V. 76 772 2009REFN ISSN 0887-3585PMID 19434754DOI 10.1002/PROT.22452 Variant Set Distributions Mapped Variants
General Structure Information 3gcx PCSK9 pcsk9:egfa (ph 7.4) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Mapped Variants
General Structure Information 1z9m CADM3 crystal structure of nectin-like molecule-1 protein domain 1 2.4Å AUTH X.DONG,F.XU,Y.GONG,J.GAO,P.LIN,T.CHEN,Y.PENG,AUTH 2 B.QIANG,J.YUAN,X.PENG,Z.RAOTITL CRYSTAL STRUCTURE OF THE V DOMAIN OF HUMANTITL 2 NECTIN-LIKE MOLECULE-1/SYNCAM3/TSLL1/IGSF4B, ATITL 3 NEURAL TISSUE-SPECIFIC IMMUNOGLOBULIN-LIKETITL 4 CELL-CELL ADHESION MOLECULEREF J.BIOL.CHEM. V. 281 10610 2006REFN ISSN 0021-9258PMID 16467305DOI 10.1074/JBC.M513459200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4li0 RAB3IL1 crystal structure of gdp-bound rab8:grab 3.3Å AUTH Z.GUO,X.HOU,R.S.GOODY,A.ITZENTITL INTERMEDIATES IN THE GUANINE NUCLEOTIDE EXCHANGE REACTION OFTITL 2 RAB8 PROTEIN CATALYZED BY GUANINE NUCLEOTIDE EXCHANGETITL 3 FACTORS RABIN8 AND GRAB.REF J.BIOL.CHEM. V. 288 32466 2013REFN ISSN 0021-9258PMID 24072714DOI 10.1074/JBC.M113.498329 Variant Set Distributions Mapped Variants
General Structure Information 4knv NANP the crystal structure of apo human hdhd4 from se-mad 1.99Å AUTH S.H.KIM,K.L.CONSTANTINE,G.J.DUKE,V.GOLDFARB,J.T.HUNT,AUTH 2 S.JOHNSON,K.KISH,H.E.KLEI,P.A.MCDONNELL,W.J.METZLER,AUTH 3 L.MUELLER,M.A.POSS,C.R.FAIRCHILD,R.S.BHIDETITL DESIGN, SYNTHESIS, FUNCTIONAL AND STRUCTURALTITL 2 CHARACTERIZATION OF AN INHIBITOR OFTITL 3 N-ACETYLNEURAMINATE-9-PHOSPHATE PHOSPHATASE: OBSERVATION OFTITL 4 EXTENSIVE DYNAMICS IN AN ENZYME/INHIBITOR COMPLEX.REF BIOORG.MED.CHEM.LETT. V. 23 4107 2013REFN ISSN 0960-894XPMID 23747226DOI 10.1016/J.BMCL.2013.05.052 Variant Set […]
General Structure Information 4esr AHI1 molecular and structural characterization of the sh3 domain of ahi-1 in regulation of cellular resistance of bcr-abl+ chronic myeloid leukemia cells to tyrosine kinase inhibitors 1.53Å AUTH X.LIU,M.CHEN,P.LOBO,J.AN,S.W.GRACE CHENG,A.MORADIAN,AUTH 2 G.B.MORIN,F.VAN PETEGEM,X.JIANGTITL MOLECULAR AND STRUCTURAL CHARACTERIZATION OF THE SH3 DOMAINTITL 2 OF AHI-1 IN REGULATION OF CELLULAR RESISTANCE OF BCR-ABL(+)TITL […]
General Structure Information 3gni STRADA structure of strad and mo25 2.35Å AUTH E.ZEQIRAJ,B.M.FILIPPI,S.GOLDIE,I.NAVRATILOVA,J.BOUDEAU,AUTH 2 M.DEAK,D.R.ALESSI,D.M.VAN AALTENTITL ATP AND MO25ALPHA REGULATE THE CONFORMATIONAL STATE OF THETITL 2 STRADALPHA PSEUDOKINASE AND ACTIVATION OF THE LKB1 TUMOURTITL 3 SUPPRESSORREF PLOS BIOL. V. 7 E1000 2009REFN ISSN 1544-9173PMID 19513107DOI 10.1371/JOURNAL.PBIO.1000126 Variant Set Distributions Mapped Variants
General Structure Information 3b76 LNX1 crystal structure of the third pdz domain of human ligand-of-numb protein-x (lnx1) in complex with the c-terminal peptide from the coxsackievirus and adenovirus receptor 1.75Å AUTH E.UGOCHUKWU,N.BURGESS-BROWN,G.BERRIDGE,J.ELKINS,G.BUNKOCZI,AUTH 2 A.C.W.PIKE,M.SUNDSTROM,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,AUTH 3 O.GILEADI,F.VON DELFT,D.DOYLETITL CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN OF HUMANTITL 2 LIGAND-OF-NUMB PROTEIN-X (LNX1) IN COMPLEX WITH THETITL 3 […]
General Structure Information 3smt SETD3 crystal structure of human set domain-containing protein3 2.04Å AUTH H.ZENG,A.DONG,J.R.WALKER,P.LOPPNAU,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF HUMAN SET DOMAIN-CONTAINING PROTEIN3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ma2 RASGRP2 solution structure of rasgrp2 ef hands bound to calcium -1.0Å AUTH J.S.IWIG,Y.VERCOULEN,R.DAS,T.BARROS,A.LIMNANDER,Y.CHE,AUTH 2 J.G.PELTON,D.E.WEMMER,J.P.ROOSE,J.KURIYANTITL STRUCTURAL ANALYSIS OF AUTOINHIBITION IN THE RAS-SPECIFICTITL 2 EXCHANGE FACTOR RASGRP1.REF ELIFE V. 2 00813 2013REFN ESSN 2050-084XPMID 23908768DOI 10.7554/ELIFE.00813 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants