Assessment of Structural Intolerance and Durability
General Structure Information 4hwn FCRLA crystal structure of the second ig-c2 domain of human fc-receptor like a (fcrla), isoform 9 [nysgrc-005836] 2.01Å AUTH P.R.KUMAR,S.G.NATHENSON,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE SECOND IG-C2 DOMAIN OF THE HUMANTITL 2 FC-RECEPTOR LIKE A, ISOFORM 9 [NYSGRC-005836]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4dxr SYNE1 human sun2-kash1 complex 2.32Å AUTH B.A.SOSA,A.ROTHBALLER,U.KUTAY,T.U.SCHWARTZTITL LINC COMPLEXES FORM BY BINDING OF THREE KASH PEPTIDES TOTITL 2 DOMAIN INTERFACES OF TRIMERIC SUN PROTEINS.REF CELL(CAMBRIDGE,MASS.) V. 149 1035 2012REFN ISSN 0092-8674PMID 22632968DOI 10.1016/J.CELL.2012.03.046 Variant Set Distributions Mapped Variants
General Structure Information 3ihj GPT2 human alanine aminotransferase 2 in complex with plp 2.3Å AUTH M.WISNIEWSKA,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,A.KOTZSCH,M.MOCHE,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,H.SCHULERTITL HUMAN GLUTAMATE PYRUVATE TRANSAMINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1vf6 INADL 2.1 angstrom crystal structure of the pals-1-l27n and patj l27 heterodimer complex 2.1Å AUTH Y.LI,D.KARNAK,B.DEMELER,B.MARGOLIS,A.LAVIETITL STRUCTURAL BASIS FOR L27 DOMAIN-MEDIATED ASSEMBLYTITL 2 OF SIGNALING AND CELL POLARITY COMPLEXES.REF EMBO J. V. 23 2723 2004REFN ISSN 0261-4189PMID 15241471DOI 10.1038/SJ.EMBOJ.7600294 Variant Set Distributions Mapped Variants
General Structure Information 4k30 NAGS structure of the n-acetyltransferase domain of human n-acetylglutamate synthase 2.1Å AUTH G.ZHAO,Z.JIN,N.M.ALLEWELL,M.TUCHMAN,D.SHITITL CRYSTAL STRUCTURE OF THE N-ACETYLTRANSFERASE DOMAIN OF HUMANTITL 2 N-ACETYL-L-GLUTAMATE SYNTHASE IN COMPLEX WITHTITL 3 N-ACETYL-L-GLUTAMATE PROVIDES INSIGHTS INTO ITS CATALYTICTITL 4 AND REGULATORY MECHANISMS.REF PLOS ONE V. 8 70369 2013REFN ESSN 1932-6203PMID 23894642DOI 10.1371/JOURNAL.PONE.0070369 Variant Set Distributions […]
General Structure Information 3ixe LIMS2 structural basis of competition between pinch1 and pinch2 for binding to the ankyrin repeat domain of integrin-linked kinase 1.9Å AUTH B.P.CHISWELL,A.L.STIEGLER,Z.RAZINIA,E.NALIBOTSKI,AUTH 2 T.J.BOGGON,D.A.CALDERWOODTITL STRUCTURAL BASIS OF COMPETITION BETWEEN PINCH1 ANDTITL 2 PINCH2 FOR BINDING TO THE ANKYRIN REPEAT DOMAIN OFTITL 3 INTEGRIN-LINKED KINASE.REF J.STRUCT.BIOL. V. 170 157 2010REFN ISSN 1047-8477PMID […]
General Structure Information 2bjn TRAPPC6B x-ray structure of human tpc6 1.7Å AUTH D.KUMMEL,J.J.MUELLER,Y.ROSKE,R.MISSELWITZ,K.BUSSOW,AUTH 2 U.HEINEMANNTITL THE STRUCTURE OF THE TRAPP SUBUNIT TPC6 SUGGESTS A MODELTITL 2 FOR A TRAPP SUBCOMPLEX.REF EMBO REP. V. 6 787 2005REFN ISSN 1469-221XPMID 16025134DOI 10.1038/SJ.EMBOR.7400463 Variant Set Distributions Mapped Variants
General Structure Information 1wxt EPS8L3 solution structure of the sh3 domain of human hypothetical protein flj21522 -1.0Å AUTH M.YONEYAMA,K.SAITO,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF HUMANTITL 2 HYPOTHETICAL PROTEIN FLJ21522REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3s93 TDRD5 crystal structure of conserved motif in tdrd5 2.28Å AUTH X.CHAO,W.TEMPEL,C.BIAN,J.KANIA,A.K.WERNIMONT,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MINTITL CRYSTAL STRUCTURE OF CONSERVED MOTIF IN TDRD5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3l11 RNF168 crystal structure of the ring domain of rnf168 2.12Å AUTH S.J.CAMPBELL,R.A.EDWARDS,C.C.LEUNG,D.NECULAI,C.D.HODGE,AUTH 2 S.DHE-PAGANON,J.N.GLOVERTITL MOLECULAR INSIGHTS INTO THE FUNCTION OF RING FINGERTITL 2 (RNF)-CONTAINING PROTEINS HRNF8 AND HRNF168 INTITL 3 UBC13/MMS2-DEPENDENT UBIQUITYLATION.REF J.BIOL.CHEM. V. 287 23900 2012REFN ISSN 0021-9258PMID 22589545DOI 10.1074/JBC.M112.359653 Variant Set Distributions Mapped Variants