Assessment of Structural Intolerance and Durability
General Structure Information 2frg TREML1 structure of the immunoglobulin-like domain of human tlt-1 1.19Å AUTH J.L.GATTIS,A.V.WASHINGTON,M.M.CHISHOLM,L.QUIGLEY,AUTH 2 A.SZYK,D.W.MCVICAR,J.LUBKOWSKITITL THE STRUCTURE OF THE EXTRACELLULAR DOMAIN OFTITL 2 TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLSTITL 3 LIKE TRANSCRIPT-1 AND EVIDENCE FOR A NATURALLYTITL 4 OCCURRING SOLUBLE FRAGMENT.REF J.BIOL.CHEM. V. 281 13396 2006REFN ISSN 0021-9258PMID 16505478DOI 10.1074/JBC.M600489200 Variant Set […]
General Structure Information 2l0b PJA1 solution nmr structure of zinc finger domain of e3 ubiquitin-protein ligase praja-1 from homo sapiens, northeast structural genomics consortium (nesg) target hr4710b -1.0Å AUTH G.LIU,S.TONG,R.XIAO,T.B.ACTON,J.K.EVERETT,G.T.MONTELIONETITL SOLUTION STRUCTURE OF ZINC FINGER DOMAIN OF E3TITL 2 UBIQUITIN-PROTEIN LIGASE PROTEIN PRAJA-1 FROM HOMO SAPIENS,TITL 3 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGETTITL 4 HR4710BREF […]
General Structure Information 3cbq REM2 crystal structure of the human rem2 gtpase with bound gdp 1.82Å AUTH L.NEDYALKOVA,Y.SHEN,Y.TONG,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN REM2 GTPASE WITHTITL 2 BOUND GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3iq7 GSG2 crystal structure of human haspin in complex with 5-iodotubercidin 2.0Å AUTH J.ESWARAN,D.PATNAIK,P.FILIPPAKOPOULOS,F.WANG,R.L.STEIN,AUTH 2 J.W.MURRAY,J.M.HIGGINS,S.KNAPPTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE ATYPICALTITL 2 HUMAN KINASE HASPIN.REF PROC.NATL.ACAD.SCI.USA V. 106 20198 2009REFN ISSN 0027-8424PMID 19918057DOI 10.1073/PNAS.0901989106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2yyo SPRYD3 crystal sturcture of human spry domain 2.0Å AUTH S.KISHISHITA,T.UCHIKUBO-KAMO,K.MURAYAMA,T.TERADA,AUTH 2 L.CHEN,Z.Q.FU,J.CHRZAS,M.SHIROUZU,B.C.WANG,AUTH 3 S.YOKOYAMATITL CRYSTAL STURCTURE OF HUMAN SPRY DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2y1x CARM1 crystal structure of coactivator associated arginine methyltransferase 1 (carm1) in complex with sinefungin and indole inhibitor 2.4Å AUTH J.S.SACK,S.THIEFFINE,T.BANDIERA,M.FASOLINI,G.J.DUKE,AUTH 2 L.JAYARAMAN,K.F.KISH,H.E.KLEI,A.V.PURANDARE,P.ROSETTANI,AUTH 3 S.TROIANI,D.XIE,J.A.BERTRANDTITL STRUCTURAL BASIS FOR CARM1 INHIBITION BY INDOLE ANDTITL 2 PYRAZOLE INHIBITORSREF BIOCHEM.J. V. 436 331 2011REFN ISSN 0264-6021PMID 21410432DOI 10.1042/BJ20102161 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2pla GPD1L crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein 2.51Å AUTH J.UPPENBERG,C.SMEE,V.HOZJAN,K.KAVANAGH,G.BUNKOCZI,AUTH 2 E.PAPAGRIGORIOU,A.C.W.PIKE,E.UGOCHUKWU,C.UMEANO,F.VON DELFT,AUTH 3 J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLYCEROL-3-PHOSPHATETITL 2 DEHYDROGENASE 1-LIKE PROTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3wbp CLEC4C crystal structure of carbohydrate recognition domain of blood dendritic cell antigen-2 (bdca2) lectin (crystal form-1) 1.8Å AUTH M.NAGAE,A.IKEDA,Y.KITAGO,N.MATSUMOTO,K.YAMAMOTO,Y.YAMAGUCHITITL CRYSTAL STRUCTURES OF CARBOHYDRATE RECOGNITION DOMAIN OFTITL 2 BLOOD DENDRITIC CELL ANTIGEN-2 (BDCA2) REVEAL A COMMONTITL 3 DOMAIN-SWAPPED DIMERREF PROTEINS 2013REFN ESSN 1097-0134PMID 24425442DOI 10.1002/PROT.24504 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2kom PARD3 solution structure of humar par-3b pdz2 (residues 451-549) -1.0Å AUTH D.R.JENSEN,C.WOYTOVICH,M.LI,P.DUVNJAK,M.S.CASSIDY,AUTH 2 R.O.FREDERICK,L.F.BERGEMAN,F.C.PETERSON,B.F.VOLKMANTITL RAPID, ROBOTIC, SMALL-SCALE PROTEIN PRODUCTION FORTITL 2 NMR SCREENING AND STRUCTURE DETERMINATION.REF PROTEIN SCI. V. 19 570 2010REFN ISSN 0961-8368PMID 20073081DOI 10.1002/PRO.335 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ycu MYH14 crystal structure of human non muscle myosin 2c in pre-power stroke state 2.25Å AUTH K.CHINTHALAPUDI,S.M.HEISSLER,D.J.MANSTEINTITL CRYSTAL STRUCTURE OF HUMAN NON MUSCLE MYOSIN 2C INTITL 2 PRE-POWER STROKE STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants