Assessment of Structural Intolerance and Durability
General Structure Information 1ax8 LEP human obesity protein, leptin 2.4Å AUTH F.ZHANG,M.B.BASINSKI,J.M.BEALS,S.L.BRIGGS,L.M.CHURGAY,AUTH 2 D.K.CLAWSON,R.D.DIMARCHI,T.C.FURMAN,J.E.HALE,H.M.HSIUNG,AUTH 3 B.E.SCHONER,D.P.SMITH,X.Y.ZHANG,J.P.WERY,R.W.SCHEVITZTITL CRYSTAL STRUCTURE OF THE OBESE PROTEIN LEPTIN-E100.REF NATURE V. 387 206 1997REFN ISSN 0028-0836PMID 9144295DOI 10.1038/387206A0 Variant Set Distributions Mapped Variants
General Structure Information 2rnf RNASE4 x-ray crystal structure of human ribonuclease 4 in complex with d(up) 2.4Å AUTH S.S.TERZYAN,R.PERACAULA,R.DE LLORENS,Y.TSUSHIMA,AUTH 2 H.YAMADA,M.SENO,F.X.GOMIS-RUTH,M.COLLTITL THE THREE-DIMENSIONAL STRUCTURE OF HUMAN RNASE 4,TITL 2 UNLIGANDED AND COMPLEXED WITH D(UP), REVEALS THETITL 3 BASIS FOR ITS URIDINE SELECTIVITY.REF J.MOL.BIOL. V. 285 205 1999REFN ISSN 0022-2836PMID 9878400DOI 10.1006/JMBI.1998.2288 Variant Set Distributions […]
General Structure Information 2ozo ZAP70 autoinhibited intact human zap-70 2.6Å AUTH S.DEINDL,T.A.KADLECEK,T.BRDICKA,X.CAO,A.WEISS,AUTH 2 J.KURIYANTITL STRUCTURAL BASIS FOR THE INHIBITION OF TYROSINETITL 2 KINASE ACTIVITY OF ZAP-70.REF CELL(CAMBRIDGE,MASS.) V. 129 735 2007REFN ISSN 0092-8674PMID 17512407DOI 10.1016/J.CELL.2007.03.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2je0 ANP32A crystal structure of pp32 2.4Å AUTH T.HUYTON,C.WOLBERGERTITL THE CRYSTAL STRUCTURE OF THE TUMOR SUPPRESSOR PROTEIN PP32TITL 2 (ANP32A): STRUCTURAL INSIGHTS INTO ANP32 FAMILY OFTITL 3 PROTEINS.REF PROTEIN SCI. V. 16 1308 2007REFN ISSN 0961-8368PMID 17567741DOI 10.1110/PS.072803507 Variant Set Distributions Mapped Variants
General Structure Information 2wjx GRIA2 crystal structure of the human ionotropic glutamate receptor glur2 atd region at 4.1 a resolution 4.1Å AUTH A.CLAYTON,C.SIEBOLD,R.J.C.GILBERT,G.C.SUTTON,AUTH 2 K.HARLOS,R.A.J.MCILHINNEY,E.Y.JONES,A.R.ARICESCUTITL CRYSTAL STRUCTURE OF THE GLUR2 AMINO-TERMINALTITL 2 DOMAIN PROVIDES INSIGHTS INTO THE ARCHITECTURE ANDTITL 3 ASSEMBLY OF IONOTROPIC GLUTAMATE RECEPTORS.REF J.MOL.BIOL. V. 392 1125 2009REFN ISSN 0022-2836PMID 19651138DOI 10.1016/J.JMB.2009.07.082 Variant […]
General Structure Information 2z3r IL15 crystal structure of the il-15/il-15ra complex 2.0Å AUTH M.CHIRIFU,C.HAYASHI,T.NAKAMURA,S.TOMA,T.SHUTO,H.KAI,AUTH 2 Y.YAMAGATA,S.J.DAVIS,S.IKEMIZUTITL CRYSTAL STRUCTURE OF THE IL-15-IL-15RALPHA COMPLEX, ATITL 2 CYTOKINE-RECEPTOR UNIT PRESENTED IN TRANSREF NAT.IMMUNOL. V. 8 1001 2007REFN ISSN 1529-2908PMID 17643103DOI 10.1038/NI1492 Variant Set Distributions Mapped Variants
General Structure Information 4iqr HNF4A multi-domain organization of the hnf4alpha nuclear receptor complex on dna 2.9Å AUTH V.CHANDRA,P.HUANG,N.POTLURI,D.WU,Y.KIM,F.RASTINEJADTITL MULTIDOMAIN INTEGRATION IN THE STRUCTURE OF THE HNF-4 ALPHATITL 2 NUCLEAR RECEPTOR COMPLEX.REF NATURE V. 495 394 2013REFN ISSN 0028-0836PMID 23485969DOI 10.1038/NATURE11966 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mkj KIF5B human kinesin motor domain with docked neck linker 2.7Å AUTH C.V.SINDELAR,M.J.BUDNY,S.RICE,N.NABER,R.FLETTERICK,AUTH 2 R.COOKETITL TWO CONFORMATIONS IN THE HUMAN KINESIN POWERTITL 2 STROKE DEFINED BY X-RAY CRYSTALLOGRAPHY AND EPRTITL 3 SPECTROSCOPY.REF NAT.STRUCT.BIOL. V. 9 844 2002REFN ISSN 1072-8368PMID 12368902 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1rjb FLT3 crystal structure of flt3 2.1Å AUTH J.GRIFFITH,J.BLACK,C.FAERMAN,L.SWENSON,M.WYNN,F.LU,AUTH 2 J.LIPPKE,K.SAXENATITL THE STRUCTURAL BASIS FOR AUTOINHIBITION OF FLT3 BYTITL 2 THE JUXTAMEMBRANE DOMAIN.REF MOL.CELL V. 13 169 2004REFN ISSN 1097-2765PMID 14759363DOI 10.1016/S1097-2765(03)00505-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1s5o CRAT structural and mutational characterization of l-carnitine binding to human carnitine acetyltransferase 1.8Å AUTH L.GOVINDASAMY,T.KUKAR,W.LIAN,B.PEDERSEN,Y.GU,AUTH 2 M.AGBANDJE-MCKENNA,S.JIN,R.MCKENNA,D.WUTITL STRUCTURAL AND MUTATIONAL CHARACTERIZATION OFTITL 2 L-CARNITINE BINDING TO HUMAN CARNITINETITL 3 ACETYLTRANSFERASE.REF J.STRUCT.BIOL. V. 146 416 2004REFN ISSN 1047-8477PMID 15099582DOI 10.1016/J.JSB.2004.01.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants