Assessment of Structural Intolerance and Durability
General Structure Information 1d1j PFN2 crystal structure of human profilin ii 2.2Å AUTH I.M.NODELMAN,G.D.BOWMAN,U.LINDBERG,C.E.SCHUTTTITL X-RAY STRUCTURE DETERMINATION OF HUMAN PROFILINTITL 2 II: A COMPARATIVE STRUCTURAL ANALYSIS OF HUMANTITL 3 PROFILINS.REF J.MOL.BIOL. V. 294 1271 1999REFN ISSN 0022-2836PMID 10600384DOI 10.1006/JMBI.1999.3318 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1elr STIP1 crystal structure of the tpr2a domain of hop in complex with the hsp90 peptide meevd 1.9Å AUTH C.SCHEUFLER,A.BRINKER,G.BOURENKOV,S.PEGORARO,AUTH 2 L.MORODER,H.BARTUNIK,F.U.HARTL,I.MOAREFITITL STRUCTURE OF TPR DOMAIN-PEPTIDE COMPLEXES:TITL 2 CRITICAL ELEMENTS IN THE ASSEMBLY OF THETITL 3 HSP70-HSP90 MULTICHAPERONE MACHINE.REF CELL(CAMBRIDGE,MASS.) V. 101 199 2000REFN ISSN 0092-8674PMID 10786835DOI 10.1016/S0092-8674(00)80830-2 Variant Set Distributions Mapped […]
General Structure Information 1imv SERPINF1 2.85 a crystal structure of pedf 2.85Å AUTH M.SIMONOVIC,P.G.GETTINS,K.VOLZTITL CRYSTAL STRUCTURE OF HUMAN PEDF, A POTENT ANTI-ANGIOGENICTITL 2 AND NEURITE GROWTH-PROMOTING FACTOR.REF PROC.NATL.ACAD.SCI.USA V. 98 11131 2001REFN ISSN 0027-8424PMID 11562499DOI 10.1073/PNAS.211268598 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n3k USP8 the catalytic domain of usp8 in complex with a usp8 specific inhibitor 2.6Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K […]
General Structure Information 2edb DCC solution structure of the fourth fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2×29 TNFSF9 crystal structure of human4-1bb ligand ectodomain 2.3Å AUTH E.Y.WON,K.CHA,J.S.BYUN,D.U.KIM,S.SHIN,B.AHN,Y.H.KIM,AUTH 2 A.J.RICE,T.WALZ,B.S.KWON,H.S.CHOTITL THE STRUCTURE OF THE TRIMER OF HUMAN 4-1BB LIGANDTITL 2 IS UNIQUE AMONG MEMBERS OF THE TUMOR NECROSISTITL 3 FACTOR SUPERFAMILY.REF J.BIOL.CHEM. V. 285 9202 2010REFN ISSN 0021-9258PMID 20032458DOI 10.1074/JBC.M109.084442 Variant Set Distributions Mapped Variants
General Structure Information 1bnl COL18A1 zinc dependent dimers observed in crystals of human endostatin 2.9Å AUTH Y.H.DING,K.JAVAHERIAN,K.M.LO,R.CHOPRA,T.BOEHM,AUTH 2 J.LANCIOTTI,B.A.HARRIS,Y.LI,R.SHAPIRO,E.HOHENESTER,AUTH 3 R.TIMPL,J.FOLKMAN,D.C.WILEYTITL ZINC-DEPENDENT DIMERS OBSERVED IN CRYSTALS OFTITL 2 HUMAN ENDOSTATIN.REF PROC.NATL.ACAD.SCI.USA V. 95 10443 1998REFN ISSN 0027-8424PMID 9724722DOI 10.1073/PNAS.95.18.10443 Variant Set Distributions Mapped Variants
General Structure Information 2wwy RECQL structure of human recq-like helicase in complex with a dna substrate 2.9Å AUTH A.C.W.PIKE,Y.ZHANG,C.SCHNECKE,A.CHAIKUAD,T.KROJER,AUTH 2 C.D.O.COOPER,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,C.BOUNTRA,O.GILEADITITL RECQ1 HELICASE-DRIVEN DNA UNWINDING, ANNEALING, AND BRANCHTITL 2 MIGRATION: INSIGHTS FROM DNA COMPLEX STRUCTURESREF PROC.NATL.ACAD.SCI.USA V. 112 4286 2015REFN ISSN 0027-8424PMID 25831490DOI 10.1073/PNAS.1417594112 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3rze HRH1 structure of the human histamine h1 receptor in complex with doxepin 3.1Å AUTH T.SHIMAMURA,M.SHIROISHI,S.WEYAND,H.TSUJIMOTO,G.WINTER,AUTH 2 V.KATRITCH,R.ABAGYAN,V.CHEREZOV,W.LIU,G.W.HAN,T.KOBAYASHI,AUTH 3 R.C.STEVENS,S.IWATATITL STRUCTURE OF THE HUMAN HISTAMINE H1 RECEPTOR COMPLEX WITHTITL 2 DOXEPIN.REF NATURE V. 475 65 2011REFN ISSN 0028-0836PMID 21697825DOI 10.1038/NATURE10236 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3l5h IL6ST crystal structure of the full ectodomain of human gp130: new insights into the molecular assembly of receptor complexes 3.6Å AUTH Y.XU,N.KERSHAW,C.S.LUO,P.SOO,M.POCOCK,P.E.CZABOTAR,AUTH 2 D.J.HILTON,N.A.NICOLA,T.P.J.GARRETT,J.G.ZHANGTITL CRYSTAL STRUCTURE OF THE ENTIRE ECTODOMAIN OF GP130:TITL 2 INSIGHTS INTO THE MOLECULAR ASSEMBLY OF THE TALL CYTOKINETITL 3 RECEPTOR COMPLEXESREF TO BE PUBLISHEDREFN Variant Set Distributions […]