Assessment of Structural Intolerance and Durability
General Structure Information 3cki TIMP3 crystal structure of the tace-n-timp-3 complex 2.3Å AUTH M.WISNIEWSKA,P.GOETTIG,K.MASKOS,E.BELOUSKI,AUTH 2 D.WINTERS,R.HECHT,R.BLACK,W.BODETITL STRUCTURAL DETERMINANTS OF THE ADAM INHIBITION BYTITL 2 TIMP-3: CRYSTAL STRUCTURE OF THE TACE-N-TIMP-3TITL 3 COMPLEX.REF J.MOL.BIOL. V. 381 1307 2008REFN ISSN 0022-2836PMID 18638486DOI 10.1016/J.JMB.2008.06.088 Variant Set Distributions Mapped Variants
General Structure Information 2w2j CA8 crystal structure of the human carbonic anhydrase related protein viii 1.6Å AUTH S.S.PICAUD,J.R.C.MUNIZ,A.KRAMM,E.S.PILKA,G.KOCHAN,AUTH 2 U.OPPERMANN,W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE-TITL 2 RELATED PROTEIN VIII REVEALS THE BASIS FORTITL 3 CATALYTIC SILENCING.REF PROTEINS V. 76 507 2009REFN ISSN 0887-3585PMID 19360879DOI 10.1002/PROT.22411 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2no3 MAPK8 novel 4-anilinopyrimidines as potent jnk1 inhibitors 3.2Å AUTH M.LIU,S.WANG,J.E.CLAMPIT,R.J.GUM,D.L.HAASCH,AUTH 2 C.M.RONDINONE,J.M.TREVILLYAN,C.ABAD-ZAPATERO,AUTH 3 E.H.FRY,H.L.SHAM,G.LIUTITL DISCOVERY OF A NEW CLASS OF 4-ANILINOPYRIMIDINESTITL 2 AS POTENT C-JUN N-TERMINAL KINASE INHIBITORS:TITL 3 SYNTHESIS AND SAR STUDIES.REF BIOORG.MED.CHEM.LETT. V. 17 668 2007REFN ISSN 0960-894XPMID 17107797DOI 10.1016/J.BMCL.2006.10.093 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2bcd PPP1CC x-ray crystal structure of protein phosphatase-1 with the marine toxin motuporin bound 2.1Å AUTH J.T.MAYNES,H.A.LUU,M.M.CHERNEY,R.J.ANDERSEN,D.WILLIAMS,AUTH 2 C.F.HOLMES,M.N.JAMESTITL CRYSTAL STRUCTURES OF PROTEIN PHOSPHATASE-1 BOUND TOTITL 2 MOTUPORIN AND DIHYDROMICROCYSTIN-LA: ELUCIDATION OF THETITL 3 MECHANISM OF ENZYME INHIBITION BY CYANOBACTERIAL TOXINS.REF J.MOL.BIOL. V. 356 111 2006REFN ISSN 0022-2836PMID 16343532DOI 10.1016/J.JMB.2005.11.019 Variant Set […]
General Structure Information 2ed7 DCC solution structure of the first fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.TOMIZAWA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lqb ATP7B metal binding repeat 2 of the wilson disease protein (atp7b) -1.0Å AUTH N.V.DOLGOVA,S.NOKHRIN,C.H.YU,G.N.GEORGE,O.Y.DMITRIEVTITL COPPER CHAPERONE ATOX1 INTERACTS WITH THE METAL-BINDINGTITL 2 DOMAIN OF WILSONS DISEASE PROTEIN IN CISPLATINTITL 3 DETOXIFICATION.REF BIOCHEM.J. V. 454 147 2013REFN ISSN 0264-6021PMID 23751120DOI 10.1042/BJ20121656 Variant Set Distributions Mapped Variants
General Structure Information 2ede DCC solution structure of the sixth fibronectin type iii domain of human netrin receptor dcc -1.0Å AUTH N.TOCHIO,S.KOSHIBA,T.TOMIZAWA,M.YONEYAMA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SIXTH FIBRONECTIN TYPETITL 2 III DOMAIN OF HUMAN NETRIN RECEPTOR DCCREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3otq EPHX2 soluble epoxide hydrolase in complex with pyrazole antagonist 3.0Å AUTH H.Y.LO,C.C.MAN,R.W.FLECK,N.A.FARROW,R.H.INGRAHAM,A.KUKULKA,AUTH 2 J.R.PROUDFOOT,R.BETAGERI,T.KIRRANE,U.PATEL,R.SHARMA,AUTH 3 M.A.HOERMANN,A.KABCENELL,S.D.LOMBAERTTITL SUBSTITUTED PYRAZOLES AS NOVEL SEH ANTAGONIST: INVESTIGATIONTITL 2 OF KEY BINDING INTERACTIONS WITHIN THE CATALYTIC DOMAIN.REF BIOORG.MED.CHEM.LETT. V. 20 6379 2010REFN ISSN 0960-894XPMID 20934334DOI 10.1016/J.BMCL.2010.09.095 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3n3f COL15A1 crystal structure of the human collagen xv trimerization domain: a potent trimerizing unit common to multiplexin collagens 2.0Å AUTH J.A.WIRZ,S.P.BOUDKO,T.F.LERCH,M.S.CHAPMAN,H.P.BACHINGERTITL CRYSTAL STRUCTURE OF THE HUMAN COLLAGEN XV TRIMERIZATIONTITL 2 DOMAIN: A POTENT TRIMERIZING UNIT COMMON TO MULTIPLEXINTITL 3 COLLAGENS.REF MATRIX BIOL. V. 30 9 2011REFN ISSN 0945-053XPMID 20932905DOI 10.1016/J.MATBIO.2010.09.005 Variant […]
General Structure Information 4ekc RGS2 structure of human regulator of g protein signaling 2 (rgs2) in complex with murine galpha-q(r183c) 7.4Å AUTH M.R.NANCE,B.KREUTZ,V.M.TESMER,R.STERNE-MARR,T.KOZASA,AUTH 2 J.J.TESMERTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE REGULATOR OF GTITL 2 PROTEIN SIGNALING 2-G ALPHA Q COMPLEX.REF STRUCTURE V. 21 438 2013REFN ISSN 0969-2126PMID 23434405DOI 10.1016/J.STR.2012.12.016 Variant Set Distributions Mapped Variants