Assessment of Structural Intolerance and Durability
General Structure Information 2gry KIF2A crystal structure of the human kif2 motor domain in complex with adp 2.35Å AUTH J.WANG,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN KIF2 MOTOR DOMAIN IN COMPLEXTITL 2 WITH ADPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fbe RFPL4A crystal structure of the pryspry-domain 2.52Å AUTH C.GRUETTER,C.BRIAND,G.CAPITANI,P.R.MITTL,S.PAPIN,AUTH 2 J.TSCHOPP,M.G.GRUETTERTITL STRUCTURE OF THE PRYSPRY-DOMAIN: IMPLICATIONS FORTITL 2 AUTOINFLAMMATORY DISEASESREF FEBS LETT. V. 580 99 2006REFN ISSN 0014-5793PMID 16364311DOI 10.1016/J.FEBSLET.2005.11.076 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4a69 HDAC3 structure of hdac3 bound to corepressor and inositol tetraphosphate 2.06Å AUTH P.J.WATSON,L.FAIRALL,G.M.SANTOS,J.W.R.SCHWABETITL STRUCTURE OF HDAC3 BOUND TO CO-REPRESSOR AND INOSITOLTITL 2 TETRAPHOSPHATE.REF NATURE V. 481 335 2012REFN ISSN 0028-0836PMID 22230954DOI 10.1038/NATURE10728 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kup FRS3 solution structure of the complex of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk -1.0Å AUTH S.KOSHIBA,H.LI,Y.MOTODA,T.TOMIZAWA,T.KASAI,N.TOCHIO,AUTH 2 T.YABUKI,T.HARADA,S.WATANABE,A.TANAKA,M.SHIROUZU,T.KIGAWA,AUTH 3 T.YAMAMOTO,S.YOKOYAMATITL STRUCTURAL BASIS FOR THE RECOGNITION OFTITL 2 NUCLEOPHOSMIN-ANAPLASTIC LYMPHOMA KINASE ONCOPROTEIN BY THETITL 3 PHOSPHOTYROSINE BINDING DOMAIN OF SUC1-ASSOCIATEDTITL 4 NEUROTROPHIC FACTOR-INDUCED TYROSINE-PHOSPHORYLATED TARGET-2REF […]
General Structure Information 2jnu RGS14 solution structure of the rgs domain of human rgs14 -1.0Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,AUTH 2 A.P.TURNBULL,L.J.BALL,G.A.SCHOCH,C.GILEADI,AUTH 3 O.Y.FEDOROV,E.F.DOWLER,V.A.HIGMAN,S.Q.HUTSELL,AUTH 4 M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITSTITL 2 INTERACTION WITH HETEROTRIMERIC G PROTEINTITL 3 ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 3ifa FBP2 human muscle fructose-1,6-bisphosphatase e69q mutant in complex with amp 1.93Å AUTH M.ZARZYCKI,R.KOLODZIEJCZYK,E.MACIASZCZYK-DZIUBINSKA,AUTH 2 R.WYSOCKI,M.JASKOLSKI,A.DZUGAJTITL STRUCTURE OF E69Q MUTANT OF HUMAN MUSCLETITL 2 FRUCTOSE-1,6-BISPHOSPHATASEREF ACTA CRYSTALLOGR.,SECT.D V. 67 1028 2011REFN ISSN 0907-4449PMID 22120740DOI 10.1107/S090744491104385X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pfw GAPDHS crystal structure of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (gapds) complex with nad, a binary form 2.15Å AUTH A.CHAIKUAD,N.SHAFQAT,R.AL-MOKHTAR,G.CAMERON,A.R.CLARKE,AUTH 2 R.L.BRADY,U.OPPERMANN,J.FRAYNE,W.W.YUETITL STRUCTURE AND KINETIC CHARACTERIZATION OF HUMANTITL 2 SPERM-SPECIFIC GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE,TITL 3 GAPDS.REF BIOCHEM.J. V. 435 401 2011REFN ISSN 0264-6021PMID 21269272DOI 10.1042/BJ20101442 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1mv3 BIN1 nmr structure of the tumor suppressor bin1: alternative splicing in melanoma and interaction with c-myc -1.0Å AUTH A.PINEDA-LUCENA,C.S.HO,D.Y.MAO,Y.SHENG,R.C.LAISTER,AUTH 2 R.MUHANDIRAM,Y.LU,B.T.SEET,S.KATZ,T.SZYPERSKI,AUTH 3 L.Z.PENN,C.H.ARROWSMITHTITL A STRUCTURE-BASED MODEL OF THE C-MYC/BIN1 PROTEINTITL 2 INTERACTION SHOWS ALTERNATIVE SPLICING OF BIN1 ANDTITL 3 C-MYC PHOSPHORYLATION ARE KEY BINDING DETERMINANTS.REF J.MOL.BIOL. V. 351 182 2005REFN ISSN […]
General Structure Information 3v30 RFXANK crystal structure of the peptide bound complex of the ankyrin repeat domains of human rfxank 1.57Å AUTH C.XU,J.JIN,C.BIAN,R.LAM,R.TIAN,R.WEIST,L.YOU,J.NIE,AUTH 2 A.BOCHKAREV,W.TEMPEL,C.S.TAN,G.A.WASNEY,M.VEDADI,G.D.GISH,AUTH 3 C.H.ARROWSMITH,T.PAWSON,X.J.YANG,J.MINTITL SEQUENCE-SPECIFIC RECOGNITION OF A PXLPXI/L MOTIF BY ANTITL 2 ANKYRIN REPEAT TUMBLER LOCK.REF SCI.SIGNAL. V. 5 RA39 2012REFN ESSN 1937-9145PMID 22649097DOI 10.1126/SCISIGNAL.2002979 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2k86 FOXO3 solution structure of foxo3a forkhead domain -1.0Å AUTH F.WANG,C.B.MARSHALL,K.YAMAMOTO,G.Y.LI,M.J.PLEVIN,AUTH 2 H.YOU,T.W.MAK,M.IKURATITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF ANTITL 2 INTRAMOLECULAR INTERACTION IN FOXO3A AND ITSTITL 3 BINDING WITH P53.REF J.MOL.BIOL. V. 384 590 2008REFN ISSN 0022-2836PMID 18824006DOI 10.1016/J.JMB.2008.09.025 Variant Set Distributions Mapped Variants