Assessment of Structural Intolerance and Durability
General Structure Information 1do5 CCS human copper chaperone for superoxide dismutase domain ii 2.75Å AUTH A.L.LAMB,A.K.WERNIMONT,R.A.PUFAHL,T.V.OHALLORAN,AUTH 2 A.C.ROSENZWEIGTITL CRYSTAL STRUCTURE OF THE SECOND DOMAIN OF THETITL 2 HUMAN COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE.REF BIOCHEMISTRY V. 39 1589 2000REFN ISSN 0006-2960PMID 10677207DOI 10.1021/BI992822I Variant Set Distributions Mapped Variants
General Structure Information 2zhk LGALS9 crystal structure of human galectin-9 n-terminal crd in complex with n-acetyllactosamine dimer (crystal 1) 1.8Å AUTH M.NAGAE,N.NISHI,T.MURATA,T.USUI,T.NAKAMURA,S.WAKATSUKI,AUTH 2 R.KATOTITL STRUCTURAL ANALYSIS OF THE RECOGNITION MECHANISM OFTITL 2 POLY-N-ACETYLLACTOSAMINE BY THE HUMAN GALECTIN-9 N-TERMINALTITL 3 CARBOHYDRATE RECOGNITION DOMAIN.REF GLYCOBIOLOGY V. 19 112 2009REFN ISSN 0959-6658PMID 18977853DOI 10.1093/GLYCOB/CWN121 Variant Set Distributions Mapped […]
General Structure Information 4c59 GAK structure of gak kinase in complex with nanobody (nbgak_4) 2.8Å AUTH A.CHAIKUAD,T.KEATES,C.VINCKE,M.KAUFHOLZ,M.ZENN,B.ZIMMERMANN,AUTH 2 C.GUTIERREZ,R.ZHANG,C.HATZOS-SKINTGES,A.JOACHIMIAK,AUTH 3 S.MUYLDERMANS,F.W.HERBERG,S.KNAPP,S.MULLERTITL STRUCTURE OF CYCLIN G-ASSOCIATED KINASE (GAK) TRAPPED INTITL 2 DIFFERENT CONFORMATIONS USING NANOBODIES.REF BIOCHEM.J. V. 459 59 2014REFN ISSN 0264-6021PMID 24438162DOI 10.1042/BJ20131399 Variant Set Distributions Mapped Variants
General Structure Information 2zfu RRP8 structure of the methyltransferase-like domain of nucleomethylin 2.0Å AUTH A.MURAYAMA,K.OHMORI,A.FUJIMURA,H.MINAMI,K.YASUZAWA-TANAKA,AUTH 2 T.KURODA,S.OIE,H.DAITOKU,M.OKUWAKI,K.NAGATA,A.FUKAMIZU,AUTH 3 K.KIMURA,T.SHIMIZU,J.YANAGISAWATITL EPIGENETIC CONTROL OF RDNA LOCI IN RESPONSE TO INTRACELLULARTITL 2 ENERGY STATUSREF CELL(CAMBRIDGE,MASS.) V. 133 627 2008REFN ISSN 0092-8674PMID 18485871DOI 10.1016/J.CELL.2008.03.030 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1htj ARHGEF11 structure of the rgs-like domain from pdz-rhogef 2.2Å AUTH K.L.LONGENECKER,M.E.LEWIS,H.CHIKUMI,J.S.GUTKIND,AUTH 2 Z.S.DEREWENDATITL STRUCTURE OF THE RGS-LIKE DOMAIN FROM PDZ-RHOGEF:TITL 2 LINKING HETEROTRIMERIC G PROTEIN-COUPLED SIGNALINGTITL 3 TO RHO GTPASES.REF STRUCTURE V. 9 559 2001REFN ISSN 0969-2126PMID 11470431DOI 10.1016/S0969-2126(01)00620-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1dk8 AXIN1 crystal structure of the rgs-homologous domain of axin 1.57Å AUTH K.E.SPINK,P.POLAKIS,W.I.WEISTITL STRUCTURAL BASIS OF THE AXIN-ADENOMATOUS POLYPOSIS COLITITL 2 INTERACTION.REF EMBO J. V. 19 2270 2000REFN ISSN 0261-4189PMID 10811618DOI 10.1093/EMBOJ/19.10.2270 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3al5 TYW5 crystal structure of human tyw5 2.5Å AUTH M.KATO,Y.ARAISO,A.NOMA,A.NAGAO,T.SUZUKI,R.ISHITANI,O.NUREKITITL CRYSTAL STRUCTURE OF A NOVEL JMJC-DOMAIN-CONTAINING PROTEIN,TITL 2 TYW5, INVOLVED IN TRNA MODIFICATION.REF NUCLEIC ACIDS RES. V. 39 1576 2011REFN ISSN 0305-1048PMID 20972222DOI 10.1093/NAR/GKQ919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2e70 SUPT5H solution structure of the fifth kow motif of human transcription elongation factor spt5 -1.0Å AUTH W.TANABE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH KOW MOTIF OF HUMANTITL 2 TRANSCRIPTION ELONGATION FACTOR SPT5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qq2 ACOT7 crystal structure of c-terminal domain of human acyl-coa thioesterase 7 2.8Å AUTH R.BUSAM,L.LEHTIO,C.H.ARROWSMITH,H.BERGLUND,R.COLLINS,AUTH 2 L.G.DAHLGREN,M.D.HERMAN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRESLUND,M.HAMMARSTROM,B.M.HALLBERG,L.HOLMBERG-SCHIAVONE,AUTH 4 I.JOHANSSON,A.KALLAS,T.KARLBERG,T.KOTENYOVA,M.MOCHE,AUTH 5 P.NORDLUND,T.NYMAN,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 6 A.G.THORSELL,L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 7 C.PERSSONTITL HUMAN ACYL-COA THIOESTERASE 7.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4f80 BTN3A1 crystal structure of the human btn3a1 ectodomain 1.94Å AUTH A.PALAKODETI,A.SANDSTROM,L.SUNDARESAN,C.HARLY,S.NEDELLEC,AUTH 2 D.OLIVE,E.SCOTET,M.BONNEVILLE,E.J.ADAMSTITL THE MOLECULAR BASIS FOR MODULATION OF HUMANTITL 2 V(GAMMA)9V(DELTA)2 T CELL RESPONSES BY CD277/BUTYROPHILIN-3TITL 3 (BTN3A)-SPECIFIC ANTIBODIESREF J.BIOL.CHEM. V. 287 32780 2012REFN ISSN 0021-9258PMID 22846996DOI 10.1074/JBC.M112.384354 Variant Set Distributions Mapped Variants