General Structure Information
| PDB ID | 1htj |
| HGNC Gene Label(s) | ARHGEF11 |
| Structure Name | structure of the rgs-like domain from pdz-rhogef |
| Resolution | 2.2Å |
| Reference | AUTH K.L.LONGENECKER,M.E.LEWIS,H.CHIKUMI,J.S.GUTKIND,AUTH 2 Z.S.DEREWENDATITL STRUCTURE OF THE RGS-LIKE DOMAIN FROM PDZ-RHOGEF:TITL 2 LINKING HETEROTRIMERIC G PROTEIN-COUPLED SIGNALINGTITL 3 TO RHO GTPASES.REF STRUCTURE V. 9 559 2001REFN ISSN 0969-2126PMID 11470431DOI 10.1016/S0969-2126(01)00620-7 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 178 |
| Number Of SNVs | 43 |
| Number Of Permutations | 13537 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.128 |
| p-value | 0.159 |
COSMIC
| Number Of Residues | 178 |
| Number Of SNVs | 4 |
| Number Of Permutations | 43 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.22 |
| p-value | 0.801 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
