Assessment of Structural Intolerance and Durability
General Structure Information 2c35 POLR2D subunits rpb4 and rpb7 of human rna polymerase ii 2.7Å AUTH H.MEKA,F.WERNER,S.C.CORDELL,S.ONESTI,P.BRICKTITL CRYSTAL STRUCTURE AND RNA BINDING OF THE RPB4/RPB7TITL 2 SUBUNITS OF HUMAN RNA POLYMERASE II.REF NUCLEIC ACIDS RES. V. 33 6435 2005REFN ISSN 0305-1048PMID 16282592DOI 10.1093/NAR/GKI945 Variant Set Distributions Mapped Variants
General Structure Information 1hu3 EIF4G3 middle domain of human eif4gii 2.37Å AUTH J.MARCOTRIGIANO,I.B.LOMAKIN,N.SONENBERG,AUTH 2 T.V.PESTOVA,C.U.HELLEN,S.K.BURLEYTITL A CONSERVED HEAT DOMAIN WITHIN EIF4G DIRECTSTITL 2 ASSEMBLY OF THE TRANSLATION INITIATION MACHINERY.REF MOL.CELL V. 7 193 2001REFN ISSN 1097-2765PMID 11172724DOI 10.1016/S1097-2765(01)00167-8 Variant Set Distributions Mapped Variants
General Structure Information 4nre ALOX15B the structure of human 15-lipoxygenase-2 with a substrate mimic 2.63Å AUTH M.J.KOBE,D.B.NEAU,C.E.MITCHELL,S.G.BARTLETT,M.E.NEWCOMERTITL THE STRUCTURE OF HUMAN 15-LIPOXYGENASE-2 WITH A SUBSTRATETITL 2 MIMIC.REF J.BIOL.CHEM. V. 289 8562 2014REFN ISSN 0021-9258PMID 24497644DOI 10.1074/JBC.M113.543777 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1du3 TNFRSF10B crystal structure of trail-sdr5 2.2Å AUTH S.-S.CHA,B.-J.SUNG,Y.A.KIM,Y.L.SONG,H.J.KIM,S.KIM,AUTH 2 M.S.LEE,B.-H.OHTITL CRYSTAL STRUCTURE OF TRAIL-DR5 COMPLEX IDENTIFIESTITL 2 A CRITICAL ROLE OF THE UNIQUE FRAME INSERTION INTITL 3 CONFERRING RECOGNITION SPECIFICITYREF J.BIOL.CHEM. V. 275 31171 2000REFN ISSN 0021-9258PMID 10893238DOI 10.1074/JBC.M004414200 Variant Set Distributions Mapped Variants
General Structure Information 1s3a NDUFA2 nmr solution structure of subunit b8 from human nadh- ubiquinone oxidoreductase complex i (ci-b8) -1.0Å AUTH C.BROCKMANN,A.DIEHL,K.REHBEIN,H.STRAUSS,AUTH 2 P.SCHMIEDER,B.KORN,R.KUHNE,H.OSCHKINATTITL THE OXIDIZED SUBUNIT B8 FROM HUMAN COMPLEX ITITL 2 ADOPTS A THIOREDOXIN FOLD.REF STRUCTURE V. 12 1645 2004REFN ISSN 0969-2126PMID 15341729DOI 10.1016/J.STR.2004.06.021 Variant Set Distributions Mapped Variants
General Structure Information 1nhl SNAP23 snap-23n structure 2.3Å AUTH S.J.FREEDMAN,H.K.SONG,Y.XU,Z.Y.SUN,M.J.ECKTITL HOMOTETRAMERIC STRUCTURE OF THE SNAP-23 N-TERMINALTITL 2 COILED-COIL DOMAINREF J.BIOL.CHEM. V. 278 13462 2003REFN ISSN 0021-9258PMID 12556468DOI 10.1074/JBC.M210483200 Variant Set Distributions Mapped Variants
General Structure Information 4e6r NCK2 crystal structure of a cytoplasmic protein nck2 (nck2) from homo sapiens at 2.20 a resolution 2.2Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A CYTOPLASMIC PROTEIN NCK2 (NCK2) FROMTITL 2 HOMO SAPIENS AT 2.20 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3msh LAMTOR5 crystal structure of hepatitis b x-interacting protein at high resolution 1.51Å AUTH I.GARCIA-SAEZ,F.B.LACROIX,D.BLOT,F.GABEL,D.A.SKOUFIASTITL STRUCTURAL CHARACTERIZATION OF HBXIP: THE PROTEIN THATTITL 2 INTERACTS WITH THE ANTI-APOPTOTIC PROTEIN SURVIVIN AND THETITL 3 ONCOGENIC VIRAL PROTEIN HBX.REF J.MOL.BIOL. V. 405 331 2011REFN ISSN 0022-2836PMID 21059355DOI 10.1016/J.JMB.2010.10.046 Variant Set Distributions Mapped Variants
General Structure Information 2mk2 INPPL1 solution nmr structure of n-terminal domain (sh2 domain) of human inositol polyphosphate phosphatase-like protein 1 (inppl1) (fragment 20-117), northeast structural genomics consortium target hr9134a -1.0Å AUTH Y.YANG,T.A.RAMELOT,H.JANJUA,R.XIAO,J.K.EVERETT,AUTH 2 G.T.MONTELIONE,M.A.KENNEDYTITL SOLUTION NMR STRUCTURE OF N-TERMINAL DOMAIN (SH2 DOMAIN) OFTITL 2 HUMAN INOSITOL POLYPHOSPHATE PHOSPHATASE-LIKE PROTEIN 1TITL 3 (INPPL1) (FRAGMENT 20-117), NORTHEAST […]
General Structure Information 3geb EYA2 crystal structure of edeya2 2.4Å AUTH S.J.KIM,D.G.JEONG,S.K.JUNG,E.R.SEONGTITL STRUCTURE OF EDEYA2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants